Community-acquired pneumonia associated with cytomegalovirus persistence: prevalence and peculiarities of clinical course
The article discusses the problem of cytomegaloviral persistence asymptomatic course among young patients with community-acquired pneumonia and in healthy population group based on specific immunoglobulins M and G appearance in blood and antibody avidity value (the duration of persistent). The conne...
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2018-06-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/132125/130843 |
| _version_ | 1818391360439320576 |
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| author | K. D. Chichirelo-Konstantynovych |
| author_facet | K. D. Chichirelo-Konstantynovych |
| author_sort | K. D. Chichirelo-Konstantynovych |
| collection | DOAJ |
| description | The article discusses the problem of cytomegaloviral persistence asymptomatic course among young patients with community-acquired pneumonia and in healthy population group based on specific immunoglobulins M and G appearance in blood and antibody avidity value (the duration of persistent). The connection between viral persistence and prognosis of community-acquired pneumonia course (by pneumonia severity index in PORT) is also recognized.
Aim of the scientific work is to study the prevalence of cytomegaloviral persistence among young patients with community-acquired pneumonia for optimization the plan of clinical examination and prognosis for this patient category.
Materials and methods. One hundred and five patients with community-acquired pneumonia and 61 healthy individuals (aged from 18 to 44 years) were examined for cytomegaloviral biomarkers (CMV IgG, CMV IgG avidity) and by PORT-scale. Positive result for viral persistence was compared with gender, age subtypes and pneumonia severity index in both groups.
Results. Cytomegaloviral persistence prevalence rate among patients with community-acquired pneumonia was 48.2 % versus 20.5 % among healthy individuals (p = 0.003). The patients with community-acquired pneumonia had higher CMV IgG avidity value (p = 0.007), it was more common for female patients (P = 0.043; χ2 = 8.164). The cytomegaloviral persistence prevalence increased with age (P = 0,045) and correlated with pneumonia severity index according to PORT-scale (P < 0.0001).
Conclusions. The patients with community-acquired pneumonia differ in significantly higher cytomegaloviral prevalence rate (P = 0.003) from the healthy respondents. This rate increases with age, negatively impacts the pneumonia prognosis (by PORT-score). The duration of cytomegaloviral persistence (based on the CMV IgG avidity value recognition) does not depend on age in both comparison groups (P > 0.05). |
| first_indexed | 2024-12-14T05:12:17Z |
| format | Article |
| id | doaj.art-54fa47ecc5ea4055a73f552410e68c5d |
| institution | Directory Open Access Journal |
| issn | 2306-4145 2310-1210 |
| language | English |
| last_indexed | 2024-12-14T05:12:17Z |
| publishDate | 2018-06-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj.art-54fa47ecc5ea4055a73f552410e68c5d2022-12-21T23:15:56ZengZaporozhye State Medical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102018-06-01336637010.14739/2310-1210.2018.3.132125Community-acquired pneumonia associated with cytomegalovirus persistence: prevalence and peculiarities of clinical courseK. D. Chichirelo-KonstantynovychThe article discusses the problem of cytomegaloviral persistence asymptomatic course among young patients with community-acquired pneumonia and in healthy population group based on specific immunoglobulins M and G appearance in blood and antibody avidity value (the duration of persistent). The connection between viral persistence and prognosis of community-acquired pneumonia course (by pneumonia severity index in PORT) is also recognized. Aim of the scientific work is to study the prevalence of cytomegaloviral persistence among young patients with community-acquired pneumonia for optimization the plan of clinical examination and prognosis for this patient category. Materials and methods. One hundred and five patients with community-acquired pneumonia and 61 healthy individuals (aged from 18 to 44 years) were examined for cytomegaloviral biomarkers (CMV IgG, CMV IgG avidity) and by PORT-scale. Positive result for viral persistence was compared with gender, age subtypes and pneumonia severity index in both groups. Results. Cytomegaloviral persistence prevalence rate among patients with community-acquired pneumonia was 48.2 % versus 20.5 % among healthy individuals (p = 0.003). The patients with community-acquired pneumonia had higher CMV IgG avidity value (p = 0.007), it was more common for female patients (P = 0.043; χ2 = 8.164). The cytomegaloviral persistence prevalence increased with age (P = 0,045) and correlated with pneumonia severity index according to PORT-scale (P < 0.0001). Conclusions. The patients with community-acquired pneumonia differ in significantly higher cytomegaloviral prevalence rate (P = 0.003) from the healthy respondents. This rate increases with age, negatively impacts the pneumonia prognosis (by PORT-score). The duration of cytomegaloviral persistence (based on the CMV IgG avidity value recognition) does not depend on age in both comparison groups (P > 0.05).http://zmj.zsmu.edu.ua/article/view/132125/130843cytomegaloviruspneumoniaPORTantibodies |
| spellingShingle | K. D. Chichirelo-Konstantynovych Community-acquired pneumonia associated with cytomegalovirus persistence: prevalence and peculiarities of clinical course Zaporožskij Medicinskij Žurnal cytomegalovirus pneumonia PORT antibodies |
| title | Community-acquired pneumonia associated with cytomegalovirus persistence: prevalence and peculiarities of clinical course |
| title_full | Community-acquired pneumonia associated with cytomegalovirus persistence: prevalence and peculiarities of clinical course |
| title_fullStr | Community-acquired pneumonia associated with cytomegalovirus persistence: prevalence and peculiarities of clinical course |
| title_full_unstemmed | Community-acquired pneumonia associated with cytomegalovirus persistence: prevalence and peculiarities of clinical course |
| title_short | Community-acquired pneumonia associated with cytomegalovirus persistence: prevalence and peculiarities of clinical course |
| title_sort | community acquired pneumonia associated with cytomegalovirus persistence prevalence and peculiarities of clinical course |
| topic | cytomegalovirus pneumonia PORT antibodies |
| url | http://zmj.zsmu.edu.ua/article/view/132125/130843 |
| work_keys_str_mv | AT kdchichirelokonstantynovych communityacquiredpneumoniaassociatedwithcytomegaloviruspersistenceprevalenceandpeculiaritiesofclinicalcourse |