Influence of different menstrual phases on the Bispectral Index during dexmedetomidine sedation
To investigate the influence of different menstrual phases on the Bispectral Index (BIS) during dexmedetomidine (Dex) sedation, 40 patients with regular menstrual cycle, American Society of Anesthesiologists I–II, aged 18–40 years, undergoing selective gynecologic laparoscopic surgery, were enrolled...
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| Format: | Article |
| Language: | English |
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Wiley
2016-11-01
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| Series: | Kaohsiung Journal of Medical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X16302005 |
| _version_ | 1818967899348402176 |
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| author | Chao Han Sheng-Jin Ge Shao-Qiang Huang Yao-Jun Lu Ning Li |
| author_facet | Chao Han Sheng-Jin Ge Shao-Qiang Huang Yao-Jun Lu Ning Li |
| author_sort | Chao Han |
| collection | DOAJ |
| description | To investigate the influence of different menstrual phases on the Bispectral Index (BIS) during dexmedetomidine (Dex) sedation, 40 patients with regular menstrual cycle, American Society of Anesthesiologists I–II, aged 18–40 years, undergoing selective gynecologic laparoscopic surgery, were enrolled. According to different menstrual phases and the serum progesterone concentration, they were divided into two groups: the follicular phase group (Group F) and the luteal phase group (Group L), and each group had 20 patients. Before anesthesia induction, patients were infused with an initial loading dose of Dex (1 μg/kg) for 10 minutes and then 0.5 μg/kg/h for 20 minutes. BIS and the changes in hemodynamic and respiratory parameters were recorded within those 30 minutes. Time to lower BIS to 70 and 60 in Group L was shorter than that in Group F (9.4 ± 1.3 minutes vs. 11.3 ± 2.1 minutes, p = 0.005; 11.3 ± 2.4 minutes vs. 14.0 ± 3.6 minutes, p = 0.021). The number of patients whose BIS reached 50 in Group L was greater than that in Group F (15 vs. 8, p < 0.05). The lowest BIS value in the Group L was lower than that in Group F (46.8 ± 6.3 vs. 55.3 ± 5.5, p = 0.006), and the heart rate of patients in both groups showed a decrease (p < 0.05). The sedative effect of Dex was more significant in patients during the luteal phase than during the follicular phase. |
| first_indexed | 2024-12-20T13:56:07Z |
| format | Article |
| id | doaj.art-54fa56be9eeb46ecb1f43538032361b9 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-20T13:56:07Z |
| publishDate | 2016-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-54fa56be9eeb46ecb1f43538032361b92022-12-21T19:38:26ZengWileyKaohsiung Journal of Medical Sciences1607-551X2016-11-01321158659210.1016/j.kjms.2016.09.001Influence of different menstrual phases on the Bispectral Index during dexmedetomidine sedationChao Han0Sheng-Jin Ge1Shao-Qiang Huang2Yao-Jun Lu3Ning Li4Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Anesthesia, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, ChinaDepartment of Anesthesia, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, ChinaDepartment of Anesthesia, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, ChinaTo investigate the influence of different menstrual phases on the Bispectral Index (BIS) during dexmedetomidine (Dex) sedation, 40 patients with regular menstrual cycle, American Society of Anesthesiologists I–II, aged 18–40 years, undergoing selective gynecologic laparoscopic surgery, were enrolled. According to different menstrual phases and the serum progesterone concentration, they were divided into two groups: the follicular phase group (Group F) and the luteal phase group (Group L), and each group had 20 patients. Before anesthesia induction, patients were infused with an initial loading dose of Dex (1 μg/kg) for 10 minutes and then 0.5 μg/kg/h for 20 minutes. BIS and the changes in hemodynamic and respiratory parameters were recorded within those 30 minutes. Time to lower BIS to 70 and 60 in Group L was shorter than that in Group F (9.4 ± 1.3 minutes vs. 11.3 ± 2.1 minutes, p = 0.005; 11.3 ± 2.4 minutes vs. 14.0 ± 3.6 minutes, p = 0.021). The number of patients whose BIS reached 50 in Group L was greater than that in Group F (15 vs. 8, p < 0.05). The lowest BIS value in the Group L was lower than that in Group F (46.8 ± 6.3 vs. 55.3 ± 5.5, p = 0.006), and the heart rate of patients in both groups showed a decrease (p < 0.05). The sedative effect of Dex was more significant in patients during the luteal phase than during the follicular phase.http://www.sciencedirect.com/science/article/pii/S1607551X16302005Bispectral IndexDexmedetomidineMenstrual cycleSedation |
| spellingShingle | Chao Han Sheng-Jin Ge Shao-Qiang Huang Yao-Jun Lu Ning Li Influence of different menstrual phases on the Bispectral Index during dexmedetomidine sedation Kaohsiung Journal of Medical Sciences Bispectral Index Dexmedetomidine Menstrual cycle Sedation |
| title | Influence of different menstrual phases on the Bispectral Index during dexmedetomidine sedation |
| title_full | Influence of different menstrual phases on the Bispectral Index during dexmedetomidine sedation |
| title_fullStr | Influence of different menstrual phases on the Bispectral Index during dexmedetomidine sedation |
| title_full_unstemmed | Influence of different menstrual phases on the Bispectral Index during dexmedetomidine sedation |
| title_short | Influence of different menstrual phases on the Bispectral Index during dexmedetomidine sedation |
| title_sort | influence of different menstrual phases on the bispectral index during dexmedetomidine sedation |
| topic | Bispectral Index Dexmedetomidine Menstrual cycle Sedation |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X16302005 |
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