Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS
Abstract Periodontitis affects up to 50% of individuals worldwide, and 8.5% are diagnosed with diabetes. The high-comorbidity rate of these diseases may suggest, at least in part, a shared etiology and pathophysiology. Changes in oral microbial communities have been documented in the context of seve...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-04-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-022-00289-w |
| _version_ | 1818060823344447488 |
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| author | Clarisse Marotz Rebecca Molinsky Cameron Martino Bruno Bohn Sumith Roy Michael Rosenbaum Moïse Desvarieux Melana Yuzefpolskaya Bruce J. Paster David R. Jacobs Paolo C. Colombo Panos N. Papapanou Rob Knight Ryan T. Demmer |
| author_facet | Clarisse Marotz Rebecca Molinsky Cameron Martino Bruno Bohn Sumith Roy Michael Rosenbaum Moïse Desvarieux Melana Yuzefpolskaya Bruce J. Paster David R. Jacobs Paolo C. Colombo Panos N. Papapanou Rob Knight Ryan T. Demmer |
| author_sort | Clarisse Marotz |
| collection | DOAJ |
| description | Abstract Periodontitis affects up to 50% of individuals worldwide, and 8.5% are diagnosed with diabetes. The high-comorbidity rate of these diseases may suggest, at least in part, a shared etiology and pathophysiology. Changes in oral microbial communities have been documented in the context of severe periodontitis and diabetes, both independently and together. However, much less is known about the early oral microbial markers of these diseases. We used a subset of the ORIGINS project dataset, which collected detailed periodontal and cardiometabolic information from 787 healthy individuals, to identify early microbial markers of periodontitis and its association with markers of cardiometabolic health. Using state-of-the-art compositional data analysis tools, we identified the log-ratio of Treponema to Corynebacterium bacteria to be a novel Microbial Indicator of Periodontitis (MIP), and found that this MIP correlates with poor periodontal health and cardiometabolic markers early in disease pathogenesis in both subgingival plaque and saliva. |
| first_indexed | 2024-12-10T13:38:32Z |
| format | Article |
| id | doaj.art-54fad5503b97478786191cfef3ebc33f |
| institution | Directory Open Access Journal |
| issn | 2055-5008 |
| language | English |
| last_indexed | 2024-12-10T13:38:32Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj.art-54fad5503b97478786191cfef3ebc33f2022-12-22T01:46:46ZengNature Portfolionpj Biofilms and Microbiomes2055-50082022-04-018111010.1038/s41522-022-00289-wEarly microbial markers of periodontal and cardiometabolic diseases in ORIGINSClarisse Marotz0Rebecca Molinsky1Cameron Martino2Bruno Bohn3Sumith Roy4Michael Rosenbaum5Moïse Desvarieux6Melana Yuzefpolskaya7Bruce J. Paster8David R. Jacobs9Paolo C. Colombo10Panos N. Papapanou11Rob Knight12Ryan T. Demmer13Department of Pediatrics, University of California, San DiegoDivision of Epidemiology and Community Health, School of Public Health, University of MinnesotaDepartment of Pediatrics, University of California, San DiegoDivision of Epidemiology and Community Health, School of Public Health, University of MinnesotaDepartment of Epidemiology, Mailman School of Public Health, Columbia UniversityDivision of Molecular Genetics, Departments of Pediatrics and Medicine, Columbia UniversityDepartment of Epidemiology, Mailman School of Public Health, Columbia UniversityDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia UniversityDepartment of Molecular Genetics, The Forsyth InstituteDivision of Epidemiology and Community Health, School of Public Health, University of MinnesotaDivision of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia UniversityDivision of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, Columbia UniversityDepartment of Pediatrics, University of California, San DiegoDivision of Epidemiology and Community Health, School of Public Health, University of MinnesotaAbstract Periodontitis affects up to 50% of individuals worldwide, and 8.5% are diagnosed with diabetes. The high-comorbidity rate of these diseases may suggest, at least in part, a shared etiology and pathophysiology. Changes in oral microbial communities have been documented in the context of severe periodontitis and diabetes, both independently and together. However, much less is known about the early oral microbial markers of these diseases. We used a subset of the ORIGINS project dataset, which collected detailed periodontal and cardiometabolic information from 787 healthy individuals, to identify early microbial markers of periodontitis and its association with markers of cardiometabolic health. Using state-of-the-art compositional data analysis tools, we identified the log-ratio of Treponema to Corynebacterium bacteria to be a novel Microbial Indicator of Periodontitis (MIP), and found that this MIP correlates with poor periodontal health and cardiometabolic markers early in disease pathogenesis in both subgingival plaque and saliva.https://doi.org/10.1038/s41522-022-00289-w |
| spellingShingle | Clarisse Marotz Rebecca Molinsky Cameron Martino Bruno Bohn Sumith Roy Michael Rosenbaum Moïse Desvarieux Melana Yuzefpolskaya Bruce J. Paster David R. Jacobs Paolo C. Colombo Panos N. Papapanou Rob Knight Ryan T. Demmer Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS npj Biofilms and Microbiomes |
| title | Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS |
| title_full | Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS |
| title_fullStr | Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS |
| title_full_unstemmed | Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS |
| title_short | Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS |
| title_sort | early microbial markers of periodontal and cardiometabolic diseases in origins |
| url | https://doi.org/10.1038/s41522-022-00289-w |
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