Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil
Abstract INTRODUCTION: The present study evaluated the epidemiology of cryptococcal meningitis and TNFα gene polymorphisms in patients at a reference hospital in northern Brazil. METHODS: Samples from 25 patients infected with Cryptococcus spp. were collected to confirm the infection and to anal...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100658&lng=en&tlng=en |
| _version_ | 1811245488480976896 |
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| author | Alena Mileo Monteiro Diniz Danielle Cristinne Azevedo Feio Aniel de Sarom Negrão Silva Rommel Rodríguez Burbano Patrícia Danielle Lima de Lima |
| author_facet | Alena Mileo Monteiro Diniz Danielle Cristinne Azevedo Feio Aniel de Sarom Negrão Silva Rommel Rodríguez Burbano Patrícia Danielle Lima de Lima |
| author_sort | Alena Mileo Monteiro Diniz |
| collection | DOAJ |
| description | Abstract INTRODUCTION: The present study evaluated the epidemiology of cryptococcal meningitis and TNFα gene polymorphisms in patients at a reference hospital in northern Brazil. METHODS: Samples from 25 patients infected with Cryptococcus spp. were collected to confirm the infection and to analyze the TNFα gene polymorphisms. RESULTS: Cryptococcus neoformans was detected as the predominant etiological agent (100%) in HIV-positive patients. No genetic polymorphic changes were found. CONCLUSIONS: No correlation was observed between the analyzed TNFα polymorphisms and cryptococcal meningitis. |
| first_indexed | 2024-04-12T14:39:51Z |
| format | Article |
| id | doaj.art-54fb08c88c6646189f8a62ec5b3250ae |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-12T14:39:51Z |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-54fb08c88c6646189f8a62ec5b3250ae2022-12-22T03:28:53ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-984952010.1590/0037-8682-0376-2018S0037-86822019000100658Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North BrazilAlena Mileo Monteiro DinizDanielle Cristinne Azevedo FeioAniel de Sarom Negrão SilvaRommel Rodríguez BurbanoPatrícia Danielle Lima de LimaAbstract INTRODUCTION: The present study evaluated the epidemiology of cryptococcal meningitis and TNFα gene polymorphisms in patients at a reference hospital in northern Brazil. METHODS: Samples from 25 patients infected with Cryptococcus spp. were collected to confirm the infection and to analyze the TNFα gene polymorphisms. RESULTS: Cryptococcus neoformans was detected as the predominant etiological agent (100%) in HIV-positive patients. No genetic polymorphic changes were found. CONCLUSIONS: No correlation was observed between the analyzed TNFα polymorphisms and cryptococcal meningitis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100658&lng=en&tlng=enCryptococcal meningitisGenetic polymorphismsCerebrospinal fluidTNFα |
| spellingShingle | Alena Mileo Monteiro Diniz Danielle Cristinne Azevedo Feio Aniel de Sarom Negrão Silva Rommel Rodríguez Burbano Patrícia Danielle Lima de Lima Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil Revista da Sociedade Brasileira de Medicina Tropical Cryptococcal meningitis Genetic polymorphisms Cerebrospinal fluid TNFα |
| title | Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil |
| title_full | Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil |
| title_fullStr | Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil |
| title_full_unstemmed | Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil |
| title_short | Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil |
| title_sort | epidemiological and tnfα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in north brazil |
| topic | Cryptococcal meningitis Genetic polymorphisms Cerebrospinal fluid TNFα |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100658&lng=en&tlng=en |
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