Predictive Values of Procalcitonin and Presepsin for Acute Kidney Injury and 30-Day Hospital Mortality in Patients with COVID-19
<i>Background and Objectives</i>: Acute kidney injury (AKI) is a common complication in patients with coronavirus disease 2019 (COVID-19). We investigated the values of procalcitonin (PCT) and presepsin (PSS) for predicting AKI and 30-day hospital mortality in patients with COVID-19. <...
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MDPI AG
2022-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/6/727 |
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| author | Sin-Young Kim Dae-Young Hong Jong-Won Kim Sang-O Park Kyeong-Ryong Lee Kwang-Je Baek |
| author_facet | Sin-Young Kim Dae-Young Hong Jong-Won Kim Sang-O Park Kyeong-Ryong Lee Kwang-Je Baek |
| author_sort | Sin-Young Kim |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Acute kidney injury (AKI) is a common complication in patients with coronavirus disease 2019 (COVID-19). We investigated the values of procalcitonin (PCT) and presepsin (PSS) for predicting AKI and 30-day hospital mortality in patients with COVID-19. <i>Materials and Methods</i>: We retrospectively evaluated 151 patients with COVID-19 who were admitted to the hospital via the emergency department. The diagnosis of AKI was based on the Kidney Disease: Improving Global Outcomes clinical practice guidelines. <i>Results</i>: The median patient age was 77 years, and 86 patients (57%) were male. Fifty-six patients (37.1%) developed AKI, and 19 patients (12.6%) died within 30 days of hospital admission. PCT and PSS levels were significantly higher in patients with AKI and non-survivors. The cutoff values of PCT levels for predicting AKI and mortality were 2.26 ng/mL (sensitivity, 64.3%; specificity, 89.5%) and 2.67 ng/mL (sensitivity, 68.4%; specificity, 77.3%), respectively. The cutoff values of PSS levels for predicting AKI and mortality were 572 pg/mL (sensitivity, 66.0%; specificity, 69.1%) and 865 pg/mL (sensitivity, 84.6%; specificity, 76.0%), respectively. <i>Conclusion</i>: PCT and PSS are valuable biomarkers for predicting AKI and 30-day hospital mortality in patients with COVID-19. |
| first_indexed | 2024-03-09T23:06:49Z |
| format | Article |
| id | doaj.art-54fd2bcd59664259908ab9bf4524d3d8 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T23:06:49Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-54fd2bcd59664259908ab9bf4524d3d82023-11-23T17:51:29ZengMDPI AGMedicina1010-660X1648-91442022-05-0158672710.3390/medicina58060727Predictive Values of Procalcitonin and Presepsin for Acute Kidney Injury and 30-Day Hospital Mortality in Patients with COVID-19Sin-Young Kim0Dae-Young Hong1Jong-Won Kim2Sang-O Park3Kyeong-Ryong Lee4Kwang-Je Baek5Department of Emergency Medicine, Konkuk University Medical Center, Seoul 05030, KoreaDepartment of Emergency Medicine, Konkuk University School of Medicine, Seoul 05030, KoreaDepartment of Emergency Medicine, Konkuk University School of Medicine, Seoul 05030, KoreaDepartment of Emergency Medicine, Konkuk University School of Medicine, Seoul 05030, KoreaDepartment of Emergency Medicine, Konkuk University School of Medicine, Seoul 05030, KoreaDepartment of Emergency Medicine, Konkuk University School of Medicine, Seoul 05030, Korea<i>Background and Objectives</i>: Acute kidney injury (AKI) is a common complication in patients with coronavirus disease 2019 (COVID-19). We investigated the values of procalcitonin (PCT) and presepsin (PSS) for predicting AKI and 30-day hospital mortality in patients with COVID-19. <i>Materials and Methods</i>: We retrospectively evaluated 151 patients with COVID-19 who were admitted to the hospital via the emergency department. The diagnosis of AKI was based on the Kidney Disease: Improving Global Outcomes clinical practice guidelines. <i>Results</i>: The median patient age was 77 years, and 86 patients (57%) were male. Fifty-six patients (37.1%) developed AKI, and 19 patients (12.6%) died within 30 days of hospital admission. PCT and PSS levels were significantly higher in patients with AKI and non-survivors. The cutoff values of PCT levels for predicting AKI and mortality were 2.26 ng/mL (sensitivity, 64.3%; specificity, 89.5%) and 2.67 ng/mL (sensitivity, 68.4%; specificity, 77.3%), respectively. The cutoff values of PSS levels for predicting AKI and mortality were 572 pg/mL (sensitivity, 66.0%; specificity, 69.1%) and 865 pg/mL (sensitivity, 84.6%; specificity, 76.0%), respectively. <i>Conclusion</i>: PCT and PSS are valuable biomarkers for predicting AKI and 30-day hospital mortality in patients with COVID-19.https://www.mdpi.com/1648-9144/58/6/727COVID-19acute kidney injurymortalityprocalcitoninpresepsin |
| spellingShingle | Sin-Young Kim Dae-Young Hong Jong-Won Kim Sang-O Park Kyeong-Ryong Lee Kwang-Je Baek Predictive Values of Procalcitonin and Presepsin for Acute Kidney Injury and 30-Day Hospital Mortality in Patients with COVID-19 Medicina COVID-19 acute kidney injury mortality procalcitonin presepsin |
| title | Predictive Values of Procalcitonin and Presepsin for Acute Kidney Injury and 30-Day Hospital Mortality in Patients with COVID-19 |
| title_full | Predictive Values of Procalcitonin and Presepsin for Acute Kidney Injury and 30-Day Hospital Mortality in Patients with COVID-19 |
| title_fullStr | Predictive Values of Procalcitonin and Presepsin for Acute Kidney Injury and 30-Day Hospital Mortality in Patients with COVID-19 |
| title_full_unstemmed | Predictive Values of Procalcitonin and Presepsin for Acute Kidney Injury and 30-Day Hospital Mortality in Patients with COVID-19 |
| title_short | Predictive Values of Procalcitonin and Presepsin for Acute Kidney Injury and 30-Day Hospital Mortality in Patients with COVID-19 |
| title_sort | predictive values of procalcitonin and presepsin for acute kidney injury and 30 day hospital mortality in patients with covid 19 |
| topic | COVID-19 acute kidney injury mortality procalcitonin presepsin |
| url | https://www.mdpi.com/1648-9144/58/6/727 |
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