Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis
Endothelial dysfunction is a universal pathological mechanism underlying or contributing to the development/progression of many diseases, including cerebrovascular disease and multiple sclerosis. Von Willebrand factor is a multimeric glycoprotein synthesized by endothelial cells and megakaryocytes t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2021-09-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
| Subjects: | |
| Online Access: | https://nnp.ima-press.net/nnp/article/view/1651 |
| _version_ | 1797876353663500288 |
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| author | I. A. Koltsov M. Yu. Martynov A. N. Yasamanova I. A. Shchukin M. S. Fidler A. N. Boyko |
| author_facet | I. A. Koltsov M. Yu. Martynov A. N. Yasamanova I. A. Shchukin M. S. Fidler A. N. Boyko |
| author_sort | I. A. Koltsov |
| collection | DOAJ |
| description | Endothelial dysfunction is a universal pathological mechanism underlying or contributing to the development/progression of many diseases, including cerebrovascular disease and multiple sclerosis. Von Willebrand factor is a multimeric glycoprotein synthesized by endothelial cells and megakaryocytes that participates in a range of physiological and pathological processes, including primary hemostasis and coagulation. It also regulates secretion and transport of a variety of molecules, exerts a proinflammatory effect, modulates angiogenesis and smooth muscle mitotic activity, influences atherogenesis. In this review, we discuss the synthesis, secretion, and regulation of the von Willebrand factor within the context of endothelial dysfunction and other common mechanisms that play a significant role in brain tissue damage in cerebrovascular diseases and multiple sclerosis. |
| first_indexed | 2024-04-10T02:00:48Z |
| format | Article |
| id | doaj.art-54fe8ca20dcf4e9ea85c47aac2d07849 |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2024-04-10T02:00:48Z |
| publishDate | 2021-09-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-54fe8ca20dcf4e9ea85c47aac2d078492023-03-13T08:42:21ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422021-09-01131S626810.14412/2074-2711-2021-1S-62-681178Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosisI. A. Koltsov0M. Yu. Martynov1A. N. Yasamanova2I. A. Shchukin3M. S. Fidler4A. N. Boyko5N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of RussiaN.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of RussiaN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaN.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of RussiaN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaN.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of RussiaEndothelial dysfunction is a universal pathological mechanism underlying or contributing to the development/progression of many diseases, including cerebrovascular disease and multiple sclerosis. Von Willebrand factor is a multimeric glycoprotein synthesized by endothelial cells and megakaryocytes that participates in a range of physiological and pathological processes, including primary hemostasis and coagulation. It also regulates secretion and transport of a variety of molecules, exerts a proinflammatory effect, modulates angiogenesis and smooth muscle mitotic activity, influences atherogenesis. In this review, we discuss the synthesis, secretion, and regulation of the von Willebrand factor within the context of endothelial dysfunction and other common mechanisms that play a significant role in brain tissue damage in cerebrovascular diseases and multiple sclerosis.https://nnp.ima-press.net/nnp/article/view/1651von willebrand factorendothelial dysfunctioncerebrovascular diseasesstrokemultiple sclerosis |
| spellingShingle | I. A. Koltsov M. Yu. Martynov A. N. Yasamanova I. A. Shchukin M. S. Fidler A. N. Boyko Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis Неврология, нейропсихиатрия, психосоматика von willebrand factor endothelial dysfunction cerebrovascular diseases stroke multiple sclerosis |
| title | Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis |
| title_full | Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis |
| title_fullStr | Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis |
| title_full_unstemmed | Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis |
| title_short | Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis |
| title_sort | influence of von willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis |
| topic | von willebrand factor endothelial dysfunction cerebrovascular diseases stroke multiple sclerosis |
| url | https://nnp.ima-press.net/nnp/article/view/1651 |
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