M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression

M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression

We investigate crosstalk between cancer cells and stromal myeloid cells. We find that Lewis lung carcinoma cells significantly induce PPARβ/δ activity in myeloid cells in vitro and in vivo. Myeloid cell-specific knockout of PPARβ/δ results in impaired growth of implanted tumors, and this is restored...

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Bibliographic Details
Main Authors: Jonghanne Park, Sang Eun Lee, Jin Hur, Eun Byeol Hong, Jae-Il Choi, Ji-Min Yang, Ju-Young Kim, Young-Chan Kim, Hyun-Jai Cho, Jeffrey M. Peters, Seung-Bum Ryoo, Young Tae Kim, Hyo-Soo Kim
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715001709

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