The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial Agents
The rapid quantification of antimicrobial agents is important for therapeutic drug monitoring (TDM), enabling personalized dosing schemes in critically ill patients. Highly sophisticated TDM technology is becoming available, but its implementation in hospitals is still limited. Among the various pro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/10/4/128 |
| _version_ | 1797436331665653760 |
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| author | Stefano Fornasaro Dana Cialla-May Valter Sergo Alois Bonifacio |
| author_facet | Stefano Fornasaro Dana Cialla-May Valter Sergo Alois Bonifacio |
| author_sort | Stefano Fornasaro |
| collection | DOAJ |
| description | The rapid quantification of antimicrobial agents is important for therapeutic drug monitoring (TDM), enabling personalized dosing schemes in critically ill patients. Highly sophisticated TDM technology is becoming available, but its implementation in hospitals is still limited. Among the various proposed techniques, surface-enhanced Raman scattering (SERS) stands out as one of the more interesting due to its extremely high sensitivity, rapidity, and fingerprinting capabilities. Here, we present a comprehensive review of various SERS-based novel approaches applied for direct and indirect detection and quantification of antibiotic, antifungal, and antituberculosis drugs in different matrices, particularly focusing on the challenges for successful exploitation of this technique in the development of assays for point-of-care tests. |
| first_indexed | 2024-03-09T11:01:05Z |
| format | Article |
| id | doaj.art-55005121c8894e7ab9d074b580b7b324 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-09T11:01:05Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-55005121c8894e7ab9d074b580b7b3242023-12-01T01:16:26ZengMDPI AGChemosensors2227-90402022-03-0110412810.3390/chemosensors10040128The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial AgentsStefano Fornasaro0Dana Cialla-May1Valter Sergo2Alois Bonifacio3Raman Spectroscopy Lab, Department of Engineering and Architecture, University of Trieste, 34127 Trieste, ItalyLeibniz Institute of Photonic Technology, Member of the Research Alliance “Leibniz Health Technologies”, Albert-Einstein-Str. 9, 07745 Jena, GermanyRaman Spectroscopy Lab, Department of Engineering and Architecture, University of Trieste, 34127 Trieste, ItalyRaman Spectroscopy Lab, Department of Engineering and Architecture, University of Trieste, 34127 Trieste, ItalyThe rapid quantification of antimicrobial agents is important for therapeutic drug monitoring (TDM), enabling personalized dosing schemes in critically ill patients. Highly sophisticated TDM technology is becoming available, but its implementation in hospitals is still limited. Among the various proposed techniques, surface-enhanced Raman scattering (SERS) stands out as one of the more interesting due to its extremely high sensitivity, rapidity, and fingerprinting capabilities. Here, we present a comprehensive review of various SERS-based novel approaches applied for direct and indirect detection and quantification of antibiotic, antifungal, and antituberculosis drugs in different matrices, particularly focusing on the challenges for successful exploitation of this technique in the development of assays for point-of-care tests.https://www.mdpi.com/2227-9040/10/4/128antibioticsSERSbiofluidsRaman spectroscopyTDM |
| spellingShingle | Stefano Fornasaro Dana Cialla-May Valter Sergo Alois Bonifacio The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial Agents Chemosensors antibiotics SERS biofluids Raman spectroscopy TDM |
| title | The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial Agents |
| title_full | The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial Agents |
| title_fullStr | The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial Agents |
| title_full_unstemmed | The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial Agents |
| title_short | The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial Agents |
| title_sort | role of surface enhanced raman scattering for therapeutic drug monitoring of antimicrobial agents |
| topic | antibiotics SERS biofluids Raman spectroscopy TDM |
| url | https://www.mdpi.com/2227-9040/10/4/128 |
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