Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlob...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/12/6479 |
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| author | Eva Giralt-Steinhauer Joan Jiménez-Balado Isabel Fernández-Pérez Lucía Rey Álvarez Ana Rodríguez-Campello Ángel Ois Elisa Cuadrado-Godia Jordi Jiménez-Conde Jaume Roquer |
| author_facet | Eva Giralt-Steinhauer Joan Jiménez-Balado Isabel Fernández-Pérez Lucía Rey Álvarez Ana Rodríguez-Campello Ángel Ois Elisa Cuadrado-Godia Jordi Jiménez-Conde Jaume Roquer |
| author_sort | Eva Giralt-Steinhauer |
| collection | DOAJ |
| description | Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies. |
| first_indexed | 2024-03-09T23:35:57Z |
| format | Article |
| id | doaj.art-55008d540390490db42200bc7f738e32 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:35:57Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-55008d540390490db42200bc7f738e322023-11-23T17:01:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312647910.3390/ijms23126479Genetics and Epigenetics of Spontaneous Intracerebral HemorrhageEva Giralt-Steinhauer0Joan Jiménez-Balado1Isabel Fernández-Pérez2Lucía Rey Álvarez3Ana Rodríguez-Campello4Ángel Ois5Elisa Cuadrado-Godia6Jordi Jiménez-Conde7Jaume Roquer8Neurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, SpainNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, SpainNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, SpainNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, SpainNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, SpainNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, SpainNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, SpainNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, SpainNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, SpainIntracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.https://www.mdpi.com/1422-0067/23/12/6479intracerebral hemorrhagegeneticsepigenetics |
| spellingShingle | Eva Giralt-Steinhauer Joan Jiménez-Balado Isabel Fernández-Pérez Lucía Rey Álvarez Ana Rodríguez-Campello Ángel Ois Elisa Cuadrado-Godia Jordi Jiménez-Conde Jaume Roquer Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage International Journal of Molecular Sciences intracerebral hemorrhage genetics epigenetics |
| title | Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage |
| title_full | Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage |
| title_fullStr | Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage |
| title_full_unstemmed | Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage |
| title_short | Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage |
| title_sort | genetics and epigenetics of spontaneous intracerebral hemorrhage |
| topic | intracerebral hemorrhage genetics epigenetics |
| url | https://www.mdpi.com/1422-0067/23/12/6479 |
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