Mechanism and physical activities in bone-skeletal muscle crosstalk
Bone and skeletal muscle work in coordination to maintain the function of the musculoskeletal system, in which skeletal muscle contraction drives the movement of the bone lever system while bone provides insert sites for skeletal muscle through the bone-muscle junction. Existing evidence suggests th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1287972/full |
| _version_ | 1827391875582001152 |
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| author | Zhonghan Zhao Kai Yan Qiao Guan Qiang Guo Can Zhao |
| author_facet | Zhonghan Zhao Kai Yan Qiao Guan Qiang Guo Can Zhao |
| author_sort | Zhonghan Zhao |
| collection | DOAJ |
| description | Bone and skeletal muscle work in coordination to maintain the function of the musculoskeletal system, in which skeletal muscle contraction drives the movement of the bone lever system while bone provides insert sites for skeletal muscle through the bone-muscle junction. Existing evidence suggests that factors secreted by skeletal muscle and bone mediate the interaction between the two tissues. Herein, we focused on the relationship between skeletal muscle and bone and the underlying mechanism of the interaction. Exercise can promote bone strength and secrete osteocalcin and insulin-like growth factor I into the blood, thus improving muscle quality. In addition, exercise can also promote myostatin, interleukin-6, Irisin, and apelin in muscles to enter the blood so that they can act on bones to maintain the balance between bone absorption and bone formation. There is a special regulatory axis interleukin-6/osteocalcin between myokines and osteokines, which is mainly influenced by exercise. Therefore, we pay attention to the important factors in the bone-muscle intersection that are affected by exercise, which were found or their functions were expanded, which strengthened the connection between organs of the whole body, highlighting the importance of exercise and contributing to the diagnosis, prevention, and treatment of osteoporosis and sarcopenia in the clinic. |
| first_indexed | 2024-03-08T17:21:42Z |
| format | Article |
| id | doaj.art-55016fa2e66c4d04b41fd045a89300f1 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T17:21:42Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-55016fa2e66c4d04b41fd045a89300f12024-01-03T04:40:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.12879721287972Mechanism and physical activities in bone-skeletal muscle crosstalkZhonghan Zhao0Kai Yan1Qiao Guan2Qiang Guo3Can Zhao4School of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaDepartment of Orthopaedics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, ChinaCollege of Athletic Performance, Shanghai University of Sport, Shanghai, ChinaBone and skeletal muscle work in coordination to maintain the function of the musculoskeletal system, in which skeletal muscle contraction drives the movement of the bone lever system while bone provides insert sites for skeletal muscle through the bone-muscle junction. Existing evidence suggests that factors secreted by skeletal muscle and bone mediate the interaction between the two tissues. Herein, we focused on the relationship between skeletal muscle and bone and the underlying mechanism of the interaction. Exercise can promote bone strength and secrete osteocalcin and insulin-like growth factor I into the blood, thus improving muscle quality. In addition, exercise can also promote myostatin, interleukin-6, Irisin, and apelin in muscles to enter the blood so that they can act on bones to maintain the balance between bone absorption and bone formation. There is a special regulatory axis interleukin-6/osteocalcin between myokines and osteokines, which is mainly influenced by exercise. Therefore, we pay attention to the important factors in the bone-muscle intersection that are affected by exercise, which were found or their functions were expanded, which strengthened the connection between organs of the whole body, highlighting the importance of exercise and contributing to the diagnosis, prevention, and treatment of osteoporosis and sarcopenia in the clinic.https://www.frontiersin.org/articles/10.3389/fendo.2023.1287972/fullbone-skeletal muscle crosstalkmyostatinirisinIL-6OCNIGF-1 |
| spellingShingle | Zhonghan Zhao Kai Yan Qiao Guan Qiang Guo Can Zhao Mechanism and physical activities in bone-skeletal muscle crosstalk Frontiers in Endocrinology bone-skeletal muscle crosstalk myostatin irisin IL-6 OCN IGF-1 |
| title | Mechanism and physical activities in bone-skeletal muscle crosstalk |
| title_full | Mechanism and physical activities in bone-skeletal muscle crosstalk |
| title_fullStr | Mechanism and physical activities in bone-skeletal muscle crosstalk |
| title_full_unstemmed | Mechanism and physical activities in bone-skeletal muscle crosstalk |
| title_short | Mechanism and physical activities in bone-skeletal muscle crosstalk |
| title_sort | mechanism and physical activities in bone skeletal muscle crosstalk |
| topic | bone-skeletal muscle crosstalk myostatin irisin IL-6 OCN IGF-1 |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1287972/full |
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