Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety and altered circadian activity patterns
Decreased levels of Nogo-A dependent signaling have been shown to affect behavior and cognitive functions. In Nogo-A knockout and knock-down laboratory rodents, behavioral alterations were observed, possibly corresponding with human neuropsychiatric diseases of neurodevelopmental origin, particularl...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-03-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00090/full |
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| author | Tomas ePetrasek Tomas ePetrasek Iva eProkopova Martin eSladek Kamila eWeissova Iveta eVojtechova Stepan eBahnik Stepan eBahnik Anna eZemanova Kai eSchönig Stefan eBerger Björn eTews Björn eTews Björn eTews Dusan eBartsch Martin eSchwab Martin eSchwab Alena eSumova Ales eStuchlik |
| author_facet | Tomas ePetrasek Tomas ePetrasek Iva eProkopova Martin eSladek Kamila eWeissova Iveta eVojtechova Stepan eBahnik Stepan eBahnik Anna eZemanova Kai eSchönig Stefan eBerger Björn eTews Björn eTews Björn eTews Dusan eBartsch Martin eSchwab Martin eSchwab Alena eSumova Ales eStuchlik |
| author_sort | Tomas ePetrasek |
| collection | DOAJ |
| description | Decreased levels of Nogo-A dependent signaling have been shown to affect behavior and cognitive functions. In Nogo-A knockout and knock-down laboratory rodents, behavioral alterations were observed, possibly corresponding with human neuropsychiatric diseases of neurodevelopmental origin, particularly schizophrenia. This study offers further insight into behavioral manifestations of Nogo-A knockdown in laboratory rats, focusing on spatial and non-spatial cognition, anxiety levels, circadian rhythmicity and activity patterns. Demonstrated is an impairment of cognitive functions and behavioral flexibility in a spatial active avoidance task, while non-spatial memory in a step-through avoidance task was spared. No signs of anhedonia, typical for schizophrenic patients, were observed in the animals. Some measures indicated lower anxiety levels in the Nogo-A deficient group. Circadian rhythmicity in locomotor activity was preserved in the Nogo-A-knockout rats and their circadian period (tau) did not differ from controls. However, daily activity patterns were slightly altered in the knockdown animals. We conclude that a reduction of Nogo-A levels induces changes in CNS development, manifested as subtle alterations in cognitive functions, emotionality and activity patterns. |
| first_indexed | 2024-04-13T19:44:17Z |
| format | Article |
| id | doaj.art-5502254f725546e3940e84b258dc1b2f |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-13T19:44:17Z |
| publishDate | 2014-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-5502254f725546e3940e84b258dc1b2f2022-12-22T02:32:47ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-03-01810.3389/fnbeh.2014.0009078073Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety and altered circadian activity patternsTomas ePetrasek0Tomas ePetrasek1Iva eProkopova2Martin eSladek3Kamila eWeissova4Iveta eVojtechova5Stepan eBahnik6Stepan eBahnik7Anna eZemanova8Kai eSchönig9Stefan eBerger10Björn eTews11Björn eTews12Björn eTews13Dusan eBartsch14Martin eSchwab15Martin eSchwab16Alena eSumova17Ales eStuchlik18Institute of Physiology, AS CRCharles University in PragueInstitute of Physiology, AS CRInstitute of Physiology, AS CRInstitute of Physiology, AS CRInstitute of Physiology, AS CRInstitute of Physiology, AS CRUniversity of WürzburgInstitute of Physiology, AS CRCentral Institute of Mental HealthCentral Institute of Mental HealthUniversity of ZürichETH ZürichGerman Cancer Research CenterCentral Institute of Mental HealthUniversity of ZürichETH ZürichInstitute of Physiology, AS CRInstitute of Physiology, AS CRDecreased levels of Nogo-A dependent signaling have been shown to affect behavior and cognitive functions. In Nogo-A knockout and knock-down laboratory rodents, behavioral alterations were observed, possibly corresponding with human neuropsychiatric diseases of neurodevelopmental origin, particularly schizophrenia. This study offers further insight into behavioral manifestations of Nogo-A knockdown in laboratory rats, focusing on spatial and non-spatial cognition, anxiety levels, circadian rhythmicity and activity patterns. Demonstrated is an impairment of cognitive functions and behavioral flexibility in a spatial active avoidance task, while non-spatial memory in a step-through avoidance task was spared. No signs of anhedonia, typical for schizophrenic patients, were observed in the animals. Some measures indicated lower anxiety levels in the Nogo-A deficient group. Circadian rhythmicity in locomotor activity was preserved in the Nogo-A-knockout rats and their circadian period (tau) did not differ from controls. However, daily activity patterns were slightly altered in the knockdown animals. We conclude that a reduction of Nogo-A levels induces changes in CNS development, manifested as subtle alterations in cognitive functions, emotionality and activity patterns.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00090/fullAnhedoniaCognitionSpatial learningNogo-Apassive avoidancecircadian rhythmicity |
| spellingShingle | Tomas ePetrasek Tomas ePetrasek Iva eProkopova Martin eSladek Kamila eWeissova Iveta eVojtechova Stepan eBahnik Stepan eBahnik Anna eZemanova Kai eSchönig Stefan eBerger Björn eTews Björn eTews Björn eTews Dusan eBartsch Martin eSchwab Martin eSchwab Alena eSumova Ales eStuchlik Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety and altered circadian activity patterns Frontiers in Behavioral Neuroscience Anhedonia Cognition Spatial learning Nogo-A passive avoidance circadian rhythmicity |
| title | Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety and altered circadian activity patterns |
| title_full | Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety and altered circadian activity patterns |
| title_fullStr | Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety and altered circadian activity patterns |
| title_full_unstemmed | Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety and altered circadian activity patterns |
| title_short | Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety and altered circadian activity patterns |
| title_sort | nogo a deficient transgenic rats show deficits in higher cognitive functions decreased anxiety and altered circadian activity patterns |
| topic | Anhedonia Cognition Spatial learning Nogo-A passive avoidance circadian rhythmicity |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00090/full |
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