Involvement of ceramide biosynthesis in increased extracellular vesicle release in Pkd1 knock out cells

Involvement of ceramide biosynthesis in increased extracellular vesicle release in Pkd1 knock out cells

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited disorder characterized by the development of renal cysts, which frequently leads to renal failure. Hypertension and other cardiovascular symptoms contribute to the high morbidity and mortality of the disease. ADPKD is caused by mut...

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Bibliographic Details
Main Authors: Valentina Carotti, Jenny van der Wijst, Eric H. J. Verschuren, Luco Rutten, Nico Sommerdijk, Charlotte Kaffa, Vera Sommers, Juan P. Rigalli, Joost G. J. Hoenderop
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Endocrinology
Subjects:
Autosomal Dominant Polycistic Kidney Disease
ADPKD
exosomes
extracellular vesicles
purinergic signaling
extracellular ATP
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1005639/full

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