Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying
Spray drying and electrospraying are well-established drying processes that already have proven their value in the pharmaceutical field. However, there is currently still a lack of knowledge on the fundamentals of the particle formation process, thereby hampering fast and cost-effective particle eng...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/7/625 |
| _version_ | 1797563284745879552 |
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| author | Eline Boel Robin Koekoekx Sien Dedroog Iurii Babkin Maria Rosaria Vetrano Christian Clasen Guy Van den Mooter |
| author_facet | Eline Boel Robin Koekoekx Sien Dedroog Iurii Babkin Maria Rosaria Vetrano Christian Clasen Guy Van den Mooter |
| author_sort | Eline Boel |
| collection | DOAJ |
| description | Spray drying and electrospraying are well-established drying processes that already have proven their value in the pharmaceutical field. However, there is currently still a lack of knowledge on the fundamentals of the particle formation process, thereby hampering fast and cost-effective particle engineering. To get a better understanding of how functional particles are formed with respect to process and formulation parameters, it is indispensable to offer a comprehensive overview of critical aspects of the droplet drying and particle formation process. This review therefore closely relates single droplet drying to pharmaceutical applications. Although excellent reviews exist of the different aspects, there is, to the best of our knowledge, no single review that describes all steps that one should consider when trying to engineer a certain type of particle morphology. The findings presented in this article have strengthened the predictive value of single droplet drying for pharmaceutical drying applications like spray drying and electrospraying. Continuous follow-up of the particle formation process in single droplet drying experiments hence allows optimization of manufacturing processes and particle engineering approaches and acceleration of process development. |
| first_indexed | 2024-03-10T18:41:27Z |
| format | Article |
| id | doaj.art-5506b09f75e140b1b7bf00694c20a7c6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T18:41:27Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-5506b09f75e140b1b7bf00694c20a7c62023-11-20T05:50:28ZengMDPI AGPharmaceutics1999-49232020-07-0112762510.3390/pharmaceutics12070625Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and ElectrosprayingEline Boel0Robin Koekoekx1Sien Dedroog2Iurii Babkin3Maria Rosaria Vetrano4Christian Clasen5Guy Van den Mooter6Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, 3000 Leuven, BelgiumDepartment of Chemical Engineering, Soft Matter, Rheology and Technology, KU Leuven, 3001 Leuven, BelgiumDepartment of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, 3000 Leuven, BelgiumDepartment of Chemical Engineering, Soft Matter, Rheology and Technology, KU Leuven, 3001 Leuven, BelgiumDepartment of Mechanical Engineering, Applied Mechanics and Energy Conversion, KU Leuven, 3001 Leuven, BelgiumDepartment of Chemical Engineering, Soft Matter, Rheology and Technology, KU Leuven, 3001 Leuven, BelgiumDepartment of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, 3000 Leuven, BelgiumSpray drying and electrospraying are well-established drying processes that already have proven their value in the pharmaceutical field. However, there is currently still a lack of knowledge on the fundamentals of the particle formation process, thereby hampering fast and cost-effective particle engineering. To get a better understanding of how functional particles are formed with respect to process and formulation parameters, it is indispensable to offer a comprehensive overview of critical aspects of the droplet drying and particle formation process. This review therefore closely relates single droplet drying to pharmaceutical applications. Although excellent reviews exist of the different aspects, there is, to the best of our knowledge, no single review that describes all steps that one should consider when trying to engineer a certain type of particle morphology. The findings presented in this article have strengthened the predictive value of single droplet drying for pharmaceutical drying applications like spray drying and electrospraying. Continuous follow-up of the particle formation process in single droplet drying experiments hence allows optimization of manufacturing processes and particle engineering approaches and acceleration of process development.https://www.mdpi.com/1999-4923/12/7/625single droplet dryingspray dryingelectrospraying |
| spellingShingle | Eline Boel Robin Koekoekx Sien Dedroog Iurii Babkin Maria Rosaria Vetrano Christian Clasen Guy Van den Mooter Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying Pharmaceutics single droplet drying spray drying electrospraying |
| title | Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying |
| title_full | Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying |
| title_fullStr | Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying |
| title_full_unstemmed | Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying |
| title_short | Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying |
| title_sort | unraveling particle formation from single droplet drying to spray drying and electrospraying |
| topic | single droplet drying spray drying electrospraying |
| url | https://www.mdpi.com/1999-4923/12/7/625 |
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