Viruses Challenge Selectivity Barrier of Nuclear Pores
Exchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows facilitated entry of selected cargos, whose siz...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-09-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/5/10/2410 |
| _version_ | 1818219143158038528 |
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| author | Ariberto Fassati Aksana A. Labokha |
| author_facet | Ariberto Fassati Aksana A. Labokha |
| author_sort | Ariberto Fassati |
| collection | DOAJ |
| description | Exchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows facilitated entry of selected cargos, whose size can reach up to 39 nm. The translocation of large molecules is facilitated by nuclear transport receptors (NTRs) that have affinity to proteins of NPC permeability barrier. Viruses that enter the nucleus replicate evolved strategies to overcome this barrier. In this review, we will discuss the functional principles of NPC barrier and nuclear transport machinery, as well as the various strategies viruses use to cross the selective barrier of NPCs. |
| first_indexed | 2024-12-12T07:34:58Z |
| format | Article |
| id | doaj.art-550d4d2f0f41486ba2770d7ee19378cc |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-12T07:34:58Z |
| publishDate | 2013-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-550d4d2f0f41486ba2770d7ee19378cc2022-12-22T00:32:55ZengMDPI AGViruses1999-49152013-09-015102410242310.3390/v5102410Viruses Challenge Selectivity Barrier of Nuclear PoresAriberto FassatiAksana A. LabokhaExchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows facilitated entry of selected cargos, whose size can reach up to 39 nm. The translocation of large molecules is facilitated by nuclear transport receptors (NTRs) that have affinity to proteins of NPC permeability barrier. Viruses that enter the nucleus replicate evolved strategies to overcome this barrier. In this review, we will discuss the functional principles of NPC barrier and nuclear transport machinery, as well as the various strategies viruses use to cross the selective barrier of NPCs.http://www.mdpi.com/1999-4915/5/10/2410NPCimportinexportinnucleoporinFG hydrogelviral capsid |
| spellingShingle | Ariberto Fassati Aksana A. Labokha Viruses Challenge Selectivity Barrier of Nuclear Pores Viruses NPC importin exportin nucleoporin FG hydrogel viral capsid |
| title | Viruses Challenge Selectivity Barrier of Nuclear Pores |
| title_full | Viruses Challenge Selectivity Barrier of Nuclear Pores |
| title_fullStr | Viruses Challenge Selectivity Barrier of Nuclear Pores |
| title_full_unstemmed | Viruses Challenge Selectivity Barrier of Nuclear Pores |
| title_short | Viruses Challenge Selectivity Barrier of Nuclear Pores |
| title_sort | viruses challenge selectivity barrier of nuclear pores |
| topic | NPC importin exportin nucleoporin FG hydrogel viral capsid |
| url | http://www.mdpi.com/1999-4915/5/10/2410 |
| work_keys_str_mv | AT aribertofassati viruseschallengeselectivitybarrierofnuclearpores AT aksanaalabokha viruseschallengeselectivitybarrierofnuclearpores |