The Differential Systemic Biological Effects between Computer Navigation and Conventional Total Knee Arthroplasty (TKA) Surgeries: A Prospective Study
Distal femur reaming-free total knee arthroplasty (TKA) was reported to possess lower risk of acute myocardial infarction (AMI) or venous thromboembolism (VTE) than conventional TKA in a retrospective population-based study. We tried to offer prospective biological evidence by comparing the levels o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/11/1835 |
| _version_ | 1797467644983508992 |
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| author | Shu-Jui Kuo Ka-Kit Siu Kuan-Ting Wu Jih-Yang Ko Feng-Sheng Wang |
| author_facet | Shu-Jui Kuo Ka-Kit Siu Kuan-Ting Wu Jih-Yang Ko Feng-Sheng Wang |
| author_sort | Shu-Jui Kuo |
| collection | DOAJ |
| description | Distal femur reaming-free total knee arthroplasty (TKA) was reported to possess lower risk of acute myocardial infarction (AMI) or venous thromboembolism (VTE) than conventional TKA in a retrospective population-based study. We tried to offer prospective biological evidence by comparing the levels of AMI and VTE serum surrogate markers among the patients undertaking navigation and conventional TKAs to support these observations. Thirty-four participants undertaking navigation TKA and 34 patients receiving conventional TKA were recruited between February 2013 and December 2015. Blood samples were drawn from all participants before TKA, and 24 and 72 h after TKA, to assess the concentration of soluble P-selectin, matrix metalloproteinase-9 (MMP-9), C-reactive protein (CRP), and interleukin-8 (IL-8) between the participants undergoing navigation and conventional TKAs. We showed that significantly lower serum levels of soluble P-selectin 24 h after, as well as CRP 24 and 72 h after TKA could be observed in the navigation cohort. The more prominent surge of serum soluble P-selectin and CRP were perceived 24 and 72 h after TKA among the participants undergoing conventional TKA. Based upon our prospective biological evidence, the merits of navigation TKA are strengthened by lower levels of AMI and VTE serum surrogate markers. |
| first_indexed | 2024-03-09T18:55:41Z |
| format | Article |
| id | doaj.art-5510b2729bfd4c1d9123c28d1b490753 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T18:55:41Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-5510b2729bfd4c1d9123c28d1b4907532023-11-24T05:25:58ZengMDPI AGJournal of Personalized Medicine2075-44262022-11-011211183510.3390/jpm12111835The Differential Systemic Biological Effects between Computer Navigation and Conventional Total Knee Arthroplasty (TKA) Surgeries: A Prospective StudyShu-Jui Kuo0Ka-Kit Siu1Kuan-Ting Wu2Jih-Yang Ko3Feng-Sheng Wang4School of Medicine, China Medical University, Taichung 404, TaiwanDepartment of Orthopedic Surgery, Park One International Hospital, Kaohsiung 813, TaiwanDepartment of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanDepartment of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanDepartment of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanDistal femur reaming-free total knee arthroplasty (TKA) was reported to possess lower risk of acute myocardial infarction (AMI) or venous thromboembolism (VTE) than conventional TKA in a retrospective population-based study. We tried to offer prospective biological evidence by comparing the levels of AMI and VTE serum surrogate markers among the patients undertaking navigation and conventional TKAs to support these observations. Thirty-four participants undertaking navigation TKA and 34 patients receiving conventional TKA were recruited between February 2013 and December 2015. Blood samples were drawn from all participants before TKA, and 24 and 72 h after TKA, to assess the concentration of soluble P-selectin, matrix metalloproteinase-9 (MMP-9), C-reactive protein (CRP), and interleukin-8 (IL-8) between the participants undergoing navigation and conventional TKAs. We showed that significantly lower serum levels of soluble P-selectin 24 h after, as well as CRP 24 and 72 h after TKA could be observed in the navigation cohort. The more prominent surge of serum soluble P-selectin and CRP were perceived 24 and 72 h after TKA among the participants undergoing conventional TKA. Based upon our prospective biological evidence, the merits of navigation TKA are strengthened by lower levels of AMI and VTE serum surrogate markers.https://www.mdpi.com/2075-4426/12/11/1835total knee arthroplasty (TKA)navigation TKAsoluble P-selectinmatrix metalloproteinase-9 (MMP-9)C-reactive protein (CRP)interleu-kin-8 (IL-8) |
| spellingShingle | Shu-Jui Kuo Ka-Kit Siu Kuan-Ting Wu Jih-Yang Ko Feng-Sheng Wang The Differential Systemic Biological Effects between Computer Navigation and Conventional Total Knee Arthroplasty (TKA) Surgeries: A Prospective Study Journal of Personalized Medicine total knee arthroplasty (TKA) navigation TKA soluble P-selectin matrix metalloproteinase-9 (MMP-9) C-reactive protein (CRP) interleu-kin-8 (IL-8) |
| title | The Differential Systemic Biological Effects between Computer Navigation and Conventional Total Knee Arthroplasty (TKA) Surgeries: A Prospective Study |
| title_full | The Differential Systemic Biological Effects between Computer Navigation and Conventional Total Knee Arthroplasty (TKA) Surgeries: A Prospective Study |
| title_fullStr | The Differential Systemic Biological Effects between Computer Navigation and Conventional Total Knee Arthroplasty (TKA) Surgeries: A Prospective Study |
| title_full_unstemmed | The Differential Systemic Biological Effects between Computer Navigation and Conventional Total Knee Arthroplasty (TKA) Surgeries: A Prospective Study |
| title_short | The Differential Systemic Biological Effects between Computer Navigation and Conventional Total Knee Arthroplasty (TKA) Surgeries: A Prospective Study |
| title_sort | differential systemic biological effects between computer navigation and conventional total knee arthroplasty tka surgeries a prospective study |
| topic | total knee arthroplasty (TKA) navigation TKA soluble P-selectin matrix metalloproteinase-9 (MMP-9) C-reactive protein (CRP) interleu-kin-8 (IL-8) |
| url | https://www.mdpi.com/2075-4426/12/11/1835 |
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