Research progress on scleral remodeling and scleral intervention in ocular diseases
Sclera is an important tissue to maintain the structure and function of eyes.Its unique biomechanical properties influence the occurrence and development of ocular diseases. The biomechanical properties of sclera are mainly determined by extracellular matrix(ECM), which contains different types of c...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-12-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2022/12/202212015.pdf |
| _version_ | 1811215432502214656 |
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| author | Xiao-Jing Wang Chen Qiu Shao-Hong Qian |
| author_facet | Xiao-Jing Wang Chen Qiu Shao-Hong Qian |
| author_sort | Xiao-Jing Wang |
| collection | DOAJ |
| description | Sclera is an important tissue to maintain the structure and function of eyes.Its unique biomechanical properties influence the occurrence and development of ocular diseases. The biomechanical properties of sclera are mainly determined by extracellular matrix(ECM), which contains different types of collagen fibers, proteoglycan and other substances. In many ocular diseases, the change of the content and arrangement of these scleral ingredients as well as scleral biomechanics can be called scleral remodeling. In recent years, studies have shown that the scleral remodeling is a complex and dynamic process in many ocular diseases,with many key molecules and signaling pathways participating and regulating. Those key molecules and signaling pathways influencing the scleral remodeling of ocular diseases are reviewed, and the availability of scleral intervention in the treatment of ocular diseases is explored. |
| first_indexed | 2024-04-12T06:21:18Z |
| format | Article |
| id | doaj.art-5510f6428cb0468084ba8c33c109b177 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-12T06:21:18Z |
| publishDate | 2022-12-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-5510f6428cb0468084ba8c33c109b1772022-12-22T03:44:17ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232022-12-0122122010201510.3980/j.issn.1672-5123.2022.12.15202212015Research progress on scleral remodeling and scleral intervention in ocular diseasesXiao-Jing Wang0Chen Qiu1Shao-Hong Qian2Department of Ophthalmology, Eye & ENT Hospital of Fudan University;NHC Key Laboratory of Myopia;Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, ChinaDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University;NHC Key Laboratory of Myopia;Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, ChinaDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University;NHC Key Laboratory of Myopia;Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, ChinaSclera is an important tissue to maintain the structure and function of eyes.Its unique biomechanical properties influence the occurrence and development of ocular diseases. The biomechanical properties of sclera are mainly determined by extracellular matrix(ECM), which contains different types of collagen fibers, proteoglycan and other substances. In many ocular diseases, the change of the content and arrangement of these scleral ingredients as well as scleral biomechanics can be called scleral remodeling. In recent years, studies have shown that the scleral remodeling is a complex and dynamic process in many ocular diseases,with many key molecules and signaling pathways participating and regulating. Those key molecules and signaling pathways influencing the scleral remodeling of ocular diseases are reviewed, and the availability of scleral intervention in the treatment of ocular diseases is explored.http://ies.ijo.cn/cn_publish/2022/12/202212015.pdfsclera biomechanicsextracellular matrixscleral remodelingscleral interventionocular diseases |
| spellingShingle | Xiao-Jing Wang Chen Qiu Shao-Hong Qian Research progress on scleral remodeling and scleral intervention in ocular diseases Guoji Yanke Zazhi sclera biomechanics extracellular matrix scleral remodeling scleral intervention ocular diseases |
| title | Research progress on scleral remodeling and scleral intervention in ocular diseases |
| title_full | Research progress on scleral remodeling and scleral intervention in ocular diseases |
| title_fullStr | Research progress on scleral remodeling and scleral intervention in ocular diseases |
| title_full_unstemmed | Research progress on scleral remodeling and scleral intervention in ocular diseases |
| title_short | Research progress on scleral remodeling and scleral intervention in ocular diseases |
| title_sort | research progress on scleral remodeling and scleral intervention in ocular diseases |
| topic | sclera biomechanics extracellular matrix scleral remodeling scleral intervention ocular diseases |
| url | http://ies.ijo.cn/cn_publish/2022/12/202212015.pdf |
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