Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort study
Abstract Background Successful implantation and delivery require both the functional embryo and receptive endometrium in assisted reproductive technology (ART) cycles. However, little is known about embryo-endometrial interaction on live-birth. We aimed to investigate the independent effect and inte...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12958-020-00636-6 |
| _version_ | 1819092510412111872 |
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| author | Hong Lv Xiuzhu Li Jiangbo Du Xiufeng Ling Feiyang Diao Qun Lu Shiyao Tao Lei Huang Shiyao Chen Xiumei Han Kun Zhou Bo Xu Xiaoyu Liu Hongxia Ma Yankai Xia Hongbing Shen Zhibin Hu Guangfu Jin Yichun Guan Xinru Wang |
| author_facet | Hong Lv Xiuzhu Li Jiangbo Du Xiufeng Ling Feiyang Diao Qun Lu Shiyao Tao Lei Huang Shiyao Chen Xiumei Han Kun Zhou Bo Xu Xiaoyu Liu Hongxia Ma Yankai Xia Hongbing Shen Zhibin Hu Guangfu Jin Yichun Guan Xinru Wang |
| author_sort | Hong Lv |
| collection | DOAJ |
| description | Abstract Background Successful implantation and delivery require both the functional embryo and receptive endometrium in assisted reproductive technology (ART) cycles. However, little is known about embryo-endometrial interaction on live-birth. We aimed to investigate the independent effect and interaction of endometrial thickness (EMT) and embryo quality on live-birth in fresh embryo transfer (ET) cycles. Methods We conducted a retrospective cohort study including 15,012 ART cycles between 2013 and 2016 in three centers in China. Poisson regression with generalized estimating equations was employed to calculate relative risks (RRs) and 95% confidence intervals (CIs). We estimated the interaction of embryo quality and EMT on live-birth rate (LBR). Results The LBR per cycle was 42.8% overall. LBR increased with increasing EMT and reached a plateau (50.6 to 54.2%) when EMT was 11 mm or thicker. Embryo quality represented by cumulative score was associated with LBR independently of number of embryos transferred and EMT. LBR was not increased with thicker EMT when only Q1 cleavage-stage embryo transferred (aRR 0.95, 95%CI 0.61–1.46). LBR was not increased significantly with thicker EMT with transfer of two good-quality cleavage-stage embryos and any blastocyst combination except Q1 group. There was significant interaction between EMT and embryo quality on LBR for cleavage-stage ETs (P=0.023). Conclusions This study demonstrated the nonlinear EMT-LBR association and the EMT cut-off value of 11 mm which may be of more clinical significance for predicting live-birth. Embryo quality is an independent prognostic tool for LBR. Our finding of significant embryo-endometrial interaction indicates combination of EMT and embryos quality might improve the prognostic value in clinical practice for live-birth in patients undergoing transfer of 1–2 fresh cleavage-stage embryos. |
| first_indexed | 2024-12-21T22:56:46Z |
| format | Article |
| id | doaj.art-55127602d2214395a85d876a927af50c |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-21T22:56:46Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-55127602d2214395a85d876a927af50c2022-12-21T18:47:25ZengBMCReproductive Biology and Endocrinology1477-78272020-08-0118111010.1186/s12958-020-00636-6Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort studyHong Lv0Xiuzhu Li1Jiangbo Du2Xiufeng Ling3Feiyang Diao4Qun Lu5Shiyao Tao6Lei Huang7Shiyao Chen8Xiumei Han9Kun Zhou10Bo Xu11Xiaoyu Liu12Hongxia Ma13Yankai Xia14Hongbing Shen15Zhibin Hu16Guangfu Jin17Yichun Guan18Xinru Wang19State Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityDepartment of Reproduction, the Affiliated Nanjing Maternity and Child Health Hospital of Nanjing Medical UniversityDepartment of Reproduction, the First Affiliated Hospital with Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityDepartment of Reproduction, Henan Medical Maternity and Child Health Care HospitalState Key Laboratory of Reproductive Medicine, Nanjing Medical UniversityAbstract Background Successful implantation and delivery require both the functional embryo and receptive endometrium in assisted reproductive technology (ART) cycles. However, little is known about embryo-endometrial interaction on live-birth. We aimed to investigate the independent effect and interaction of endometrial thickness (EMT) and embryo quality on live-birth in fresh embryo transfer (ET) cycles. Methods We conducted a retrospective cohort study including 15,012 ART cycles between 2013 and 2016 in three centers in China. Poisson regression with generalized estimating equations was employed to calculate relative risks (RRs) and 95% confidence intervals (CIs). We estimated the interaction of embryo quality and EMT on live-birth rate (LBR). Results The LBR per cycle was 42.8% overall. LBR increased with increasing EMT and reached a plateau (50.6 to 54.2%) when EMT was 11 mm or thicker. Embryo quality represented by cumulative score was associated with LBR independently of number of embryos transferred and EMT. LBR was not increased with thicker EMT when only Q1 cleavage-stage embryo transferred (aRR 0.95, 95%CI 0.61–1.46). LBR was not increased significantly with thicker EMT with transfer of two good-quality cleavage-stage embryos and any blastocyst combination except Q1 group. There was significant interaction between EMT and embryo quality on LBR for cleavage-stage ETs (P=0.023). Conclusions This study demonstrated the nonlinear EMT-LBR association and the EMT cut-off value of 11 mm which may be of more clinical significance for predicting live-birth. Embryo quality is an independent prognostic tool for LBR. Our finding of significant embryo-endometrial interaction indicates combination of EMT and embryos quality might improve the prognostic value in clinical practice for live-birth in patients undergoing transfer of 1–2 fresh cleavage-stage embryos.http://link.springer.com/article/10.1186/s12958-020-00636-6Endometrial thicknessEmbryo qualityIVF/ICSILive-birth rate per cycleInteraction |
| spellingShingle | Hong Lv Xiuzhu Li Jiangbo Du Xiufeng Ling Feiyang Diao Qun Lu Shiyao Tao Lei Huang Shiyao Chen Xiumei Han Kun Zhou Bo Xu Xiaoyu Liu Hongxia Ma Yankai Xia Hongbing Shen Zhibin Hu Guangfu Jin Yichun Guan Xinru Wang Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort study Reproductive Biology and Endocrinology Endometrial thickness Embryo quality IVF/ICSI Live-birth rate per cycle Interaction |
| title | Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort study |
| title_full | Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort study |
| title_fullStr | Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort study |
| title_full_unstemmed | Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort study |
| title_short | Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort study |
| title_sort | effect of endometrial thickness and embryo quality on live birth rate of fresh ivf icsi cycles a retrospective cohort study |
| topic | Endometrial thickness Embryo quality IVF/ICSI Live-birth rate per cycle Interaction |
| url | http://link.springer.com/article/10.1186/s12958-020-00636-6 |
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