Disseminated Intravascular Coagulation pada Cedera Otak Traumatik
Disseminated Intravascular Coagulation (DIC) merupakan konsekuensi yang sering dan penting pada cedera otak traumatik (Traumatic Brain Injury/TBI) dan menyebabkan cedera otak sekunder. Walaupun perkembangan proses ini belum dapat dijelaskan secara keseluruhan, namun abnormalitas koagulasi darah adal...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Indonesian |
| Published: |
Indonesian Society of Neuroanesthesia & Critical Care (INA-SNACC)
2018-10-01
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| Series: | Jurnal Neuroanestesi Indonesia |
| Subjects: | |
| Online Access: | http://inasnacc.org/ojs2/index.php/jni/article/view/147 |
| _version_ | 1811294060533514240 |
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| author | Agus Baratha Suyasa Sudadi Sudadi Bambang Suryono |
| author_facet | Agus Baratha Suyasa Sudadi Sudadi Bambang Suryono |
| author_sort | Agus Baratha Suyasa |
| collection | DOAJ |
| description | Disseminated Intravascular Coagulation (DIC) merupakan konsekuensi yang sering dan penting pada cedera otak traumatik (Traumatic Brain Injury/TBI) dan menyebabkan cedera otak sekunder. Walaupun perkembangan proses ini belum dapat dijelaskan secara keseluruhan, namun abnormalitas koagulasi darah adalah bukti yang ditemukan pascatrauma. DIC adalah proses patofisiologi dan bukan merupakan suatu penyakit tersendiri. Gangguan yang terjadi meliputi ketidaktepatan, berlebihan dan aktivasi proses hemostasis yang tidak terkontrol. Karakteristik DIC adalah konsumsi faktor pembekuan darah dan trombosit dalam sirkulasi yang menimbulkan berbagai derajat obstruksi pembuluh darah mikro sehubungan dengan deposisi fibrin. Masalah dan gambaran utama akut DIC adalah perdarahan. Gangguan mekanisme hemostatik sangat penting dalam TBI. Perdarahan mikro sering terjadi di parenkim otak dan status koagulasi normal adalah penting untuk mencegah perkembangannya menjadi hematom yang lebih besar. Abnormalitas koagulasi tidak hanya hasil dari cedera, tetapi juga menyebabkan cedera sekunder. Gangguan koagulasi dalam TBI sangat kompleks dan dapat disertai dengan koagulopati dan hiperkoagulabilitas. Di temukan bukti bahwa luasnya trauma jaringan otak memiliki peran penting terhadap gangguan koagulasi dibandingkan syok traumatik maupun hipoksia. Adanya koagulopati pada TBI mengindikasikan prognosis yang buruk, sehingga pemeriksaan rutin terhadap status koagulasi harus selalu dilakukan pada semua pasien TBI.
Disseminated Intravascular Coagulation on Traumatic Brain Injury
Disseminated Intravascular Coagulation (DIC) is a frequent and important consequence of traumatic brain injury and may cause secondary brain injury. Although the mechanism of this process cannot be explained as a whole, but abnormalities of blood coagulation after trauma is the evidence. DIC in brain trauma is a pathophysiological process and is not due to a disease in itself. Disturbance includes inaccuracy, excessive and activation of uncontrolled hemostasis process. Characteristic of DIC is the consumption of blood clotting factors and platelets in the circulation that cause various degrees of micro vascular obstruction in conjunction with the deposition of fibrin. The main problem features of acute DIC are bleeding. Impaired hemostatic mechanism plays an important role in traumatic brain injury (TBI). Micro bleeding often occurs in the brain parenchyma and normal coagulation status is important to prevent its development into a larger hematoma. Coagulation abnormality is not the only discouraging factor of injury, but also lead to secondary injury. Coagulation disorders in TBI are very complex and can be accompanied by coagulopathy and hypercoagulability. Found evidence ofextented trauma in the brain tissue plays more important role to coagulation disorder than traumatic shock and hypoxia. The presence of coagulopathy in TBI indicates a poor prognosis, so the routine inspection of the coagulation status should always be performed in all patients with TBI. |
| first_indexed | 2024-04-13T05:12:00Z |
| format | Article |
| id | doaj.art-551434aae3fd494981e5fc1281edf3a1 |
| institution | Directory Open Access Journal |
| issn | 2088-9674 2460-2302 |
| language | Indonesian |
| last_indexed | 2024-04-13T05:12:00Z |
| publishDate | 2018-10-01 |
| publisher | Indonesian Society of Neuroanesthesia & Critical Care (INA-SNACC) |
| record_format | Article |
| series | Jurnal Neuroanestesi Indonesia |
| spelling | doaj.art-551434aae3fd494981e5fc1281edf3a12022-12-22T03:01:01ZindIndonesian Society of Neuroanesthesia & Critical Care (INA-SNACC)Jurnal Neuroanestesi Indonesia2088-96742460-23022018-10-01339920510.24244/jni.vol3i3.147145Disseminated Intravascular Coagulation pada Cedera Otak TraumatikAgus Baratha SuyasaSudadi SudadiBambang SuryonoDisseminated Intravascular Coagulation (DIC) merupakan konsekuensi yang sering dan penting pada cedera otak traumatik (Traumatic Brain Injury/TBI) dan menyebabkan cedera otak sekunder. Walaupun perkembangan proses ini belum dapat dijelaskan secara keseluruhan, namun abnormalitas koagulasi darah adalah bukti yang ditemukan pascatrauma. DIC adalah proses patofisiologi dan bukan merupakan suatu penyakit tersendiri. Gangguan yang terjadi meliputi ketidaktepatan, berlebihan dan aktivasi proses hemostasis yang tidak terkontrol. Karakteristik DIC adalah konsumsi faktor pembekuan darah dan trombosit dalam sirkulasi yang menimbulkan berbagai derajat obstruksi pembuluh darah mikro sehubungan dengan deposisi fibrin. Masalah dan gambaran utama akut DIC adalah perdarahan. Gangguan mekanisme hemostatik sangat penting dalam TBI. Perdarahan mikro sering terjadi di parenkim otak dan status koagulasi normal adalah penting untuk mencegah perkembangannya menjadi hematom yang lebih besar. Abnormalitas koagulasi tidak hanya hasil dari cedera, tetapi juga menyebabkan cedera sekunder. Gangguan koagulasi dalam TBI sangat kompleks dan dapat disertai dengan koagulopati dan hiperkoagulabilitas. Di temukan bukti bahwa luasnya trauma jaringan otak memiliki peran penting terhadap gangguan koagulasi dibandingkan syok traumatik maupun hipoksia. Adanya koagulopati pada TBI mengindikasikan prognosis yang buruk, sehingga pemeriksaan rutin terhadap status koagulasi harus selalu dilakukan pada semua pasien TBI. Disseminated Intravascular Coagulation on Traumatic Brain Injury Disseminated Intravascular Coagulation (DIC) is a frequent and important consequence of traumatic brain injury and may cause secondary brain injury. Although the mechanism of this process cannot be explained as a whole, but abnormalities of blood coagulation after trauma is the evidence. DIC in brain trauma is a pathophysiological process and is not due to a disease in itself. Disturbance includes inaccuracy, excessive and activation of uncontrolled hemostasis process. Characteristic of DIC is the consumption of blood clotting factors and platelets in the circulation that cause various degrees of micro vascular obstruction in conjunction with the deposition of fibrin. The main problem features of acute DIC are bleeding. Impaired hemostatic mechanism plays an important role in traumatic brain injury (TBI). Micro bleeding often occurs in the brain parenchyma and normal coagulation status is important to prevent its development into a larger hematoma. Coagulation abnormality is not the only discouraging factor of injury, but also lead to secondary injury. Coagulation disorders in TBI are very complex and can be accompanied by coagulopathy and hypercoagulability. Found evidence ofextented trauma in the brain tissue plays more important role to coagulation disorder than traumatic shock and hypoxia. The presence of coagulopathy in TBI indicates a poor prognosis, so the routine inspection of the coagulation status should always be performed in all patients with TBI.http://inasnacc.org/ojs2/index.php/jni/article/view/147koagulopatidisseminated intravascular coagulationcedera otak traumatikcoagulopathydisseminated intravascular coagulationtraumatic brain injury |
| spellingShingle | Agus Baratha Suyasa Sudadi Sudadi Bambang Suryono Disseminated Intravascular Coagulation pada Cedera Otak Traumatik Jurnal Neuroanestesi Indonesia koagulopati disseminated intravascular coagulation cedera otak traumatik coagulopathy disseminated intravascular coagulation traumatic brain injury |
| title | Disseminated Intravascular Coagulation pada Cedera Otak Traumatik |
| title_full | Disseminated Intravascular Coagulation pada Cedera Otak Traumatik |
| title_fullStr | Disseminated Intravascular Coagulation pada Cedera Otak Traumatik |
| title_full_unstemmed | Disseminated Intravascular Coagulation pada Cedera Otak Traumatik |
| title_short | Disseminated Intravascular Coagulation pada Cedera Otak Traumatik |
| title_sort | disseminated intravascular coagulation pada cedera otak traumatik |
| topic | koagulopati disseminated intravascular coagulation cedera otak traumatik coagulopathy disseminated intravascular coagulation traumatic brain injury |
| url | http://inasnacc.org/ojs2/index.php/jni/article/view/147 |
| work_keys_str_mv | AT agusbarathasuyasa disseminatedintravascularcoagulationpadacederaotaktraumatik AT sudadisudadi disseminatedintravascularcoagulationpadacederaotaktraumatik AT bambangsuryono disseminatedintravascularcoagulationpadacederaotaktraumatik |