Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial?

Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial?

Neurotrophins promote neurite outgrowth of auditory neurons and may help closing the gap to cochlear implant (CI) electrodes to enhance electrical hearing. The best concentrations and mix of neurotrophins for this nerve regrowth are unknown. Whether electrical stimulation (ES) during outgrowth is be...

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Bibliographic Details
Main Authors: Dominik Schmidbauer, Stefan Fink, Francis Rousset, Hubert Löwenheim, Pascal Senn, Rudolf Glueckert
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
nerve regeneration
cochlear implant
spiral ganglion
neurotrophin treatment
electrical stimulation
Online Access:https://www.mdpi.com/1422-0067/24/3/2013

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