Promoting metabolic inefficiency for metabolic disease
Summary: Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss. Multip...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422301920X |
| _version_ | 1797647816760229888 |
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| author | Lawrence Kazak |
| author_facet | Lawrence Kazak |
| author_sort | Lawrence Kazak |
| collection | DOAJ |
| description | Summary: Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss. Multiple energy dissipating pathways have been identified in adipose tissue and muscle. The molecular effectors of some of these pathways have been identified, but much is still left to be learned about their regulation. Understanding the molecular underpinnings of metabolic inefficiency in adipose tissue and muscle is required if these pathways are to be therapeutically targeted in the context of obesity and obesity-accelerated diseases. |
| first_indexed | 2024-03-11T15:23:04Z |
| format | Article |
| id | doaj.art-55162faaf5a04335a90fea261f5da747 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-11T15:23:04Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-55162faaf5a04335a90fea261f5da7472023-10-28T05:08:43ZengElsevieriScience2589-00422023-10-012610107843Promoting metabolic inefficiency for metabolic diseaseLawrence Kazak0Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; Corresponding authorSummary: Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss. Multiple energy dissipating pathways have been identified in adipose tissue and muscle. The molecular effectors of some of these pathways have been identified, but much is still left to be learned about their regulation. Understanding the molecular underpinnings of metabolic inefficiency in adipose tissue and muscle is required if these pathways are to be therapeutically targeted in the context of obesity and obesity-accelerated diseases.http://www.sciencedirect.com/science/article/pii/S258900422301920XHuman metabolism |
| spellingShingle | Lawrence Kazak Promoting metabolic inefficiency for metabolic disease iScience Human metabolism |
| title | Promoting metabolic inefficiency for metabolic disease |
| title_full | Promoting metabolic inefficiency for metabolic disease |
| title_fullStr | Promoting metabolic inefficiency for metabolic disease |
| title_full_unstemmed | Promoting metabolic inefficiency for metabolic disease |
| title_short | Promoting metabolic inefficiency for metabolic disease |
| title_sort | promoting metabolic inefficiency for metabolic disease |
| topic | Human metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S258900422301920X |
| work_keys_str_mv | AT lawrencekazak promotingmetabolicinefficiencyformetabolicdisease |