Differences in Willingness to Undergo <i>BRCA1/2</i> Testing and Risk Reducing Surgery among the General Public, Cancer Patients, and Healthcare Professionals: A Large Population-Based Survey
We aimed to understand the decision-making process related to the willingness to undergo <i>BRCA1/2</i> genetic testing, risk-reducing salpingo-oophorectomy (RRSO), or risk-reducing mastectomy (RRM) among the general public, cancer patients, and healthcare professionals in South Korea. I...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/5/818 |
| _version_ | 1797498597979193344 |
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| author | Yoon Jung Chang Seungyeon Cho Jungnam Joo Kum Hei Ryu Sangwon Lee Juhee Cho Myong Cheol Lim So-Youn Jung Jai Hong Han Eun Sook Lee Sun-Young Kong |
| author_facet | Yoon Jung Chang Seungyeon Cho Jungnam Joo Kum Hei Ryu Sangwon Lee Juhee Cho Myong Cheol Lim So-Youn Jung Jai Hong Han Eun Sook Lee Sun-Young Kong |
| author_sort | Yoon Jung Chang |
| collection | DOAJ |
| description | We aimed to understand the decision-making process related to the willingness to undergo <i>BRCA1/2</i> genetic testing, risk-reducing salpingo-oophorectomy (RRSO), or risk-reducing mastectomy (RRM) among the general public, cancer patients, and healthcare professionals in South Korea. In total, 3444 individuals (1496 from the general public, 1500 cancer patients, 108 clinicians, and 340 researchers) completed a survey addressing genetic testing and related risk management options in a hypothetical scenario. Differences in intent and associated factors for undergoing the above procedures or sharing test results were analyzed. Overall, 67% of participants were willing to undergo <i>BRCA1/2</i> testing, with proportions of the general public (58%), cancer patients (70%), clinicians (88%), and researchers (90%). The willingness to undergo RRSO was highest among clinicians (58%), followed by among patients (38%), the general public (33%), and researchers (32%) (<i>p</i> < 0.001). Gender, age, education level, and household income were associated with willingness to undergo genetic testing, RRM, and RRSO (<i>p</i> < 0.05). The intent for undergo genetic testing, RRM, and RRSO were affected by many factors. Finally, 69% of the general public intended to share information with family, while this percentage was 92%, 91%, and 94% for patients, clinicians, and researchers, respectively (<i>p</i> < 0.05). These results highlight the requirement for developing targeted educational materials and counseling strategies for facilitating informed decision making. |
| first_indexed | 2024-03-10T03:35:37Z |
| format | Article |
| id | doaj.art-5517944eecfd4c55b180dbcc25f8c464 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T03:35:37Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-5517944eecfd4c55b180dbcc25f8c4642023-11-23T11:45:17ZengMDPI AGJournal of Personalized Medicine2075-44262022-05-0112581810.3390/jpm12050818Differences in Willingness to Undergo <i>BRCA1/2</i> Testing and Risk Reducing Surgery among the General Public, Cancer Patients, and Healthcare Professionals: A Large Population-Based SurveyYoon Jung Chang0Seungyeon Cho1Jungnam Joo2Kum Hei Ryu3Sangwon Lee4Juhee Cho5Myong Cheol Lim6So-Youn Jung7Jai Hong Han8Eun Sook Lee9Sun-Young Kong10Division of Cancer Control & Policy, National Cancer Control Institute, National Cancer Center, Goyang 10408, KoreaDivision of Cancer Control & Policy, National Cancer Control Institute, National Cancer Center, Goyang 10408, KoreaOffice of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20852, USACenter for Cancer Prevention & Detection, National Cancer Center Hospital, Goyang 10408, KoreaCancer Data Center, National Cancer Control Institute, National Cancer Center, Goyang 10408, KoreaCenter for Clinical Epidemiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Cancer Control and Policy, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, KoreaCenter for Breast Cancer, National Cancer Center Hospital, Goyang 10408, KoreaCenter for Breast Cancer, National Cancer Center Hospital, Goyang 10408, KoreaImmuno-Oncology Branch, Division of Rare and Refractory Cancer, Research Institute, National Cancer Center, Goyang 10408, KoreaCancer Outcome & Quality Improvement Branch, Research Institute, National Cancer Center, Goyang 10408, KoreaWe aimed to understand the decision-making process related to the willingness to undergo <i>BRCA1/2</i> genetic testing, risk-reducing salpingo-oophorectomy (RRSO), or risk-reducing mastectomy (RRM) among the general public, cancer patients, and healthcare professionals in South Korea. In total, 3444 individuals (1496 from the general public, 1500 cancer patients, 108 clinicians, and 340 researchers) completed a survey addressing genetic testing and related risk management options in a hypothetical scenario. Differences in intent and associated factors for undergoing the above procedures or sharing test results were analyzed. Overall, 67% of participants were willing to undergo <i>BRCA1/2</i> testing, with proportions of the general public (58%), cancer patients (70%), clinicians (88%), and researchers (90%). The willingness to undergo RRSO was highest among clinicians (58%), followed by among patients (38%), the general public (33%), and researchers (32%) (<i>p</i> < 0.001). Gender, age, education level, and household income were associated with willingness to undergo genetic testing, RRM, and RRSO (<i>p</i> < 0.05). The intent for undergo genetic testing, RRM, and RRSO were affected by many factors. Finally, 69% of the general public intended to share information with family, while this percentage was 92%, 91%, and 94% for patients, clinicians, and researchers, respectively (<i>p</i> < 0.05). These results highlight the requirement for developing targeted educational materials and counseling strategies for facilitating informed decision making.https://www.mdpi.com/2075-4426/12/5/818<i>BRCA1</i><i>BRCA2</i>genetic testinggenetic counselingprophylactic surgical proceduresalpingo-oophorectomy |
| spellingShingle | Yoon Jung Chang Seungyeon Cho Jungnam Joo Kum Hei Ryu Sangwon Lee Juhee Cho Myong Cheol Lim So-Youn Jung Jai Hong Han Eun Sook Lee Sun-Young Kong Differences in Willingness to Undergo <i>BRCA1/2</i> Testing and Risk Reducing Surgery among the General Public, Cancer Patients, and Healthcare Professionals: A Large Population-Based Survey Journal of Personalized Medicine <i>BRCA1</i> <i>BRCA2</i> genetic testing genetic counseling prophylactic surgical procedure salpingo-oophorectomy |
| title | Differences in Willingness to Undergo <i>BRCA1/2</i> Testing and Risk Reducing Surgery among the General Public, Cancer Patients, and Healthcare Professionals: A Large Population-Based Survey |
| title_full | Differences in Willingness to Undergo <i>BRCA1/2</i> Testing and Risk Reducing Surgery among the General Public, Cancer Patients, and Healthcare Professionals: A Large Population-Based Survey |
| title_fullStr | Differences in Willingness to Undergo <i>BRCA1/2</i> Testing and Risk Reducing Surgery among the General Public, Cancer Patients, and Healthcare Professionals: A Large Population-Based Survey |
| title_full_unstemmed | Differences in Willingness to Undergo <i>BRCA1/2</i> Testing and Risk Reducing Surgery among the General Public, Cancer Patients, and Healthcare Professionals: A Large Population-Based Survey |
| title_short | Differences in Willingness to Undergo <i>BRCA1/2</i> Testing and Risk Reducing Surgery among the General Public, Cancer Patients, and Healthcare Professionals: A Large Population-Based Survey |
| title_sort | differences in willingness to undergo i brca1 2 i testing and risk reducing surgery among the general public cancer patients and healthcare professionals a large population based survey |
| topic | <i>BRCA1</i> <i>BRCA2</i> genetic testing genetic counseling prophylactic surgical procedure salpingo-oophorectomy |
| url | https://www.mdpi.com/2075-4426/12/5/818 |
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