Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues
Biofilm formation and antibiotic tolerance are regulated in Pseudomonas aeruginosa by the protein PA1396, which responds to diffusible signal factors (DSFs) produced by other bacteria. Here, An et al. synthesize DSF analogues that modulate PA1396 activity and thus biofilm formation and antibiotic to...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10271-4 |
| _version_ | 1818855981718700032 |
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| author | Shi-qi An Julie Murtagh Kate B. Twomey Manoj K. Gupta Timothy P. O’Sullivan Rebecca Ingram Miguel A. Valvano Ji-liang Tang |
| author_facet | Shi-qi An Julie Murtagh Kate B. Twomey Manoj K. Gupta Timothy P. O’Sullivan Rebecca Ingram Miguel A. Valvano Ji-liang Tang |
| author_sort | Shi-qi An |
| collection | DOAJ |
| description | Biofilm formation and antibiotic tolerance are regulated in Pseudomonas aeruginosa by the protein PA1396, which responds to diffusible signal factors (DSFs) produced by other bacteria. Here, An et al. synthesize DSF analogues that modulate PA1396 activity and thus biofilm formation and antibiotic tolerance. |
| first_indexed | 2024-12-19T08:17:14Z |
| format | Article |
| id | doaj.art-551913c042084dbbbcb6ec863181c625 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:17:14Z |
| publishDate | 2019-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-551913c042084dbbbcb6ec863181c6252022-12-21T20:29:28ZengNature PortfolioNature Communications2041-17232019-05-0110111110.1038/s41467-019-10271-4Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analoguesShi-qi An0Julie Murtagh1Kate B. Twomey2Manoj K. Gupta3Timothy P. O’Sullivan4Rebecca Ingram5Miguel A. Valvano6Ji-liang Tang7National Biofilms Innovation Centers, Biological Sciences, University of SouthamptonSchool of Microbiology, Biosciences Institute, University College CorkSchool of Microbiology, Biosciences Institute, University College CorkSchool of Chemistry, University College CorkSchool of Chemistry, University College CorkThe Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University of BelfastThe Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University of BelfastState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi UniversityBiofilm formation and antibiotic tolerance are regulated in Pseudomonas aeruginosa by the protein PA1396, which responds to diffusible signal factors (DSFs) produced by other bacteria. Here, An et al. synthesize DSF analogues that modulate PA1396 activity and thus biofilm formation and antibiotic tolerance.https://doi.org/10.1038/s41467-019-10271-4 |
| spellingShingle | Shi-qi An Julie Murtagh Kate B. Twomey Manoj K. Gupta Timothy P. O’Sullivan Rebecca Ingram Miguel A. Valvano Ji-liang Tang Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues Nature Communications |
| title | Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues |
| title_full | Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues |
| title_fullStr | Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues |
| title_full_unstemmed | Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues |
| title_short | Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues |
| title_sort | modulation of antibiotic sensitivity and biofilm formation in pseudomonas aeruginosa by interspecies signal analogues |
| url | https://doi.org/10.1038/s41467-019-10271-4 |
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