Pulmonary involvement in Schistosomiasis mansoni
The post-treatment pulmonary alterations were evaluated in patients (Study 1) and in mice (Study 2) infected with Schistosoma mansoni. Study 1: the patients were examined pre and post-treatment (with ora oxamniquine) and the following exams were performed: sputum for eosinophils and chest x-ray. Stu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1987-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800040 |
| _version_ | 1827879336208760832 |
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| author | Dirceu B. Greco Enio R. P. Pedroso J. R. Lambertucci Manoel O. C. Rocha Paulo Marcos Z. Coelho Pedro Raso Cid S. Ferreira |
| author_facet | Dirceu B. Greco Enio R. P. Pedroso J. R. Lambertucci Manoel O. C. Rocha Paulo Marcos Z. Coelho Pedro Raso Cid S. Ferreira |
| author_sort | Dirceu B. Greco |
| collection | DOAJ |
| description | The post-treatment pulmonary alterations were evaluated in patients (Study 1) and in mice (Study 2) infected with Schistosoma mansoni. Study 1: the patients were examined pre and post-treatment (with ora oxamniquine) and the following exams were performed: sputum for eosinophils and chest x-ray. Study 2: four groups of mice (total = 64) were studied; Group I (infected and treated with oxamniquine); II (infected and not treated); III (not infected and treated) and IV (not infected and not treated). All were x-rayed to check for pulmonary abnormalities pre and post-treatment and lung specimens were studied by optical microscopy and immunofluorescence. We have found abnormalities in the parameters checked in both studies and the results suggest an immunological reaction, probably due to deposition of immune complexes in the lungs, with subsequent activation of the complement system. The experimental study showed that the alterations are not dependent of the presence of eggs and/or worms of S. mansoni in the lungs, thus corroborating the hypothesis of deposition of circulating material. |
| first_indexed | 2024-03-12T18:05:19Z |
| format | Article |
| id | doaj.art-551b6cc86527448fb3afa76409d27968 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:05:19Z |
| publishDate | 1987-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-551b6cc86527448fb3afa76409d279682023-08-02T09:29:07ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601987-01-018222122710.1590/S0074-02761987000800040Pulmonary involvement in Schistosomiasis mansoniDirceu B. GrecoEnio R. P. PedrosoJ. R. LambertucciManoel O. C. RochaPaulo Marcos Z. CoelhoPedro RasoCid S. FerreiraThe post-treatment pulmonary alterations were evaluated in patients (Study 1) and in mice (Study 2) infected with Schistosoma mansoni. Study 1: the patients were examined pre and post-treatment (with ora oxamniquine) and the following exams were performed: sputum for eosinophils and chest x-ray. Study 2: four groups of mice (total = 64) were studied; Group I (infected and treated with oxamniquine); II (infected and not treated); III (not infected and treated) and IV (not infected and not treated). All were x-rayed to check for pulmonary abnormalities pre and post-treatment and lung specimens were studied by optical microscopy and immunofluorescence. We have found abnormalities in the parameters checked in both studies and the results suggest an immunological reaction, probably due to deposition of immune complexes in the lungs, with subsequent activation of the complement system. The experimental study showed that the alterations are not dependent of the presence of eggs and/or worms of S. mansoni in the lungs, thus corroborating the hypothesis of deposition of circulating material.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800040 |
| spellingShingle | Dirceu B. Greco Enio R. P. Pedroso J. R. Lambertucci Manoel O. C. Rocha Paulo Marcos Z. Coelho Pedro Raso Cid S. Ferreira Pulmonary involvement in Schistosomiasis mansoni Memorias do Instituto Oswaldo Cruz |
| title | Pulmonary involvement in Schistosomiasis mansoni |
| title_full | Pulmonary involvement in Schistosomiasis mansoni |
| title_fullStr | Pulmonary involvement in Schistosomiasis mansoni |
| title_full_unstemmed | Pulmonary involvement in Schistosomiasis mansoni |
| title_short | Pulmonary involvement in Schistosomiasis mansoni |
| title_sort | pulmonary involvement in schistosomiasis mansoni |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800040 |
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