The Effect of Intracochlear and Intratympanic Dexamethasone on Cochlear Implant Impedance
Objective: This study investigated the impact of different local corticosteroid applications on impedance measurements in patients with cochlear implants. Methods: The study was designed as a controlled, randomized, and prospective study in which 34 consecutive patients who had undergone cochlear im...
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| Format: | Article |
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Galenos Yayincilik
2023-09-01
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| Series: | Turkish Archives of Otorhinolaryngology |
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http://turkarchotolaryngol.net/archives/archive-detail/article-preview/the-effect-of-ntracochlear-and-ntratympanic-dexame/63471
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| author | Fazıl Necdet Ardıç Gökçe Aydemir Funda Tümkaya Ece Altınöz Hande Şenol |
| author_facet | Fazıl Necdet Ardıç Gökçe Aydemir Funda Tümkaya Ece Altınöz Hande Şenol |
| author_sort | Fazıl Necdet Ardıç |
| collection | DOAJ |
| description | Objective: This study investigated the impact of different local corticosteroid applications on impedance measurements in patients with cochlear implants. Methods: The study was designed as a controlled, randomized, and prospective study in which 34 consecutive patients who had undergone cochlear implant surgery were divided into three groups. The first group received intracochlear dexamethasone, in the second group the middle ear cavity was filled with dexamethasone, and the third group did not receive dexamethasone. Intraoperative, postoperative 1st week, 1st month, 3rd month, 6th-month neural response telemetry, and impedances were measured. The measurements were compared by electrode groups representing the different regions of cochlea like basal (1–7), middle (8–13), and apical (14–22) regions. Results: The intergroup analysis showed no statistically significant differences in impedance measurements of the basal, middle, and apical regions (p>0.05). However, the impedances were lower in the two dexamethasone groups, especially in the basal and middle parts. Sixth month impedances were also lower in the dexamethasone groups. There was apparent stability in the impedance of the basal region with the intracochlear application during the first week. Conclusion: Local dexamethasone applications had a potentially positive impact on the impedance of the basal and middle regions. Patients had lower impedances than the control group during follow-up and at the endpoint. The increase in the apical region may indicate that dexamethasone was not reaching the apical zone in local applications. |
| first_indexed | 2024-03-11T10:33:29Z |
| format | Article |
| id | doaj.art-551ba2d949f14b0cb4d9379bce22ea2e |
| institution | Directory Open Access Journal |
| issn | 2667-7474 |
| language | English |
| last_indexed | 2024-03-11T10:33:29Z |
| publishDate | 2023-09-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Turkish Archives of Otorhinolaryngology |
| spelling | doaj.art-551ba2d949f14b0cb4d9379bce22ea2e2023-11-14T13:29:05ZengGalenos YayincilikTurkish Archives of Otorhinolaryngology2667-74742023-09-0161310310810.4274/tao.2023.2023-6-413049054The Effect of Intracochlear and Intratympanic Dexamethasone on Cochlear Implant ImpedanceFazıl Necdet Ardıç0Gökçe Aydemir1Funda Tümkaya2Ece Altınöz3Hande Şenol4 Department of Otolaryngology-Head and Neck Surgery, Pamukkale University Faculty of Medicine, Denizli, Turkey Department of Otolaryngology-Head and Neck Surgery, Pamukkale University Faculty of Medicine, Denizli, Turkey Department of Otolaryngology-Head and Neck Surgery, Pamukkale University Faculty of Medicine, Denizli, Turkey Department of Otolaryngology-Head and Neck Surgery, Pamukkale University Faculty of Medicine, Denizli, Turkey Department of Biostatistics, Pamukkale University Faculty of Medicine, Denizli, Turkey Objective: This study investigated the impact of different local corticosteroid applications on impedance measurements in patients with cochlear implants. Methods: The study was designed as a controlled, randomized, and prospective study in which 34 consecutive patients who had undergone cochlear implant surgery were divided into three groups. The first group received intracochlear dexamethasone, in the second group the middle ear cavity was filled with dexamethasone, and the third group did not receive dexamethasone. Intraoperative, postoperative 1st week, 1st month, 3rd month, 6th-month neural response telemetry, and impedances were measured. The measurements were compared by electrode groups representing the different regions of cochlea like basal (1–7), middle (8–13), and apical (14–22) regions. Results: The intergroup analysis showed no statistically significant differences in impedance measurements of the basal, middle, and apical regions (p>0.05). However, the impedances were lower in the two dexamethasone groups, especially in the basal and middle parts. Sixth month impedances were also lower in the dexamethasone groups. There was apparent stability in the impedance of the basal region with the intracochlear application during the first week. Conclusion: Local dexamethasone applications had a potentially positive impact on the impedance of the basal and middle regions. Patients had lower impedances than the control group during follow-up and at the endpoint. The increase in the apical region may indicate that dexamethasone was not reaching the apical zone in local applications. http://turkarchotolaryngol.net/archives/archive-detail/article-preview/the-effect-of-ntracochlear-and-ntratympanic-dexame/63471 cochlear implantsdexamethasoneelectrode impedancefibrosis |
| spellingShingle | Fazıl Necdet Ardıç Gökçe Aydemir Funda Tümkaya Ece Altınöz Hande Şenol The Effect of Intracochlear and Intratympanic Dexamethasone on Cochlear Implant Impedance Turkish Archives of Otorhinolaryngology cochlear implants dexamethasone electrode impedance fibrosis |
| title | The Effect of Intracochlear and Intratympanic Dexamethasone on Cochlear Implant Impedance |
| title_full | The Effect of Intracochlear and Intratympanic Dexamethasone on Cochlear Implant Impedance |
| title_fullStr | The Effect of Intracochlear and Intratympanic Dexamethasone on Cochlear Implant Impedance |
| title_full_unstemmed | The Effect of Intracochlear and Intratympanic Dexamethasone on Cochlear Implant Impedance |
| title_short | The Effect of Intracochlear and Intratympanic Dexamethasone on Cochlear Implant Impedance |
| title_sort | effect of intracochlear and intratympanic dexamethasone on cochlear implant impedance |
| topic | cochlear implants dexamethasone electrode impedance fibrosis |
| url |
http://turkarchotolaryngol.net/archives/archive-detail/article-preview/the-effect-of-ntracochlear-and-ntratympanic-dexame/63471
|
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