An Experimentally Defined Hypoxia Gene Signature in Glioblastoma and Its Modulation by Metformin

An Experimentally Defined Hypoxia Gene Signature in Glioblastoma and Its Modulation by Metformin

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor, characterized by a high degree of intertumoral heterogeneity. However, a common feature of the GBM microenvironment is hypoxia, which can promote radio- and chemotherapy resistance, immunosuppression, angiogenesis,...

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Bibliographic Details
Main Authors: Marta Calvo Tardón, Eliana Marinari, Denis Migliorini, Viviane Bes, Stoyan Tankov, Emily Charrier, Thomas A McKee, Valérie Dutoit, Pierre-Yves Dietrich, Erika Cosset, Paul R Walker
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biology
Subjects:
hypoxia
physioxia
glioblastoma
glioblastoma microenvironment
metformin
hypoxia gene signature
Online Access:https://www.mdpi.com/2079-7737/9/9/264

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