Dual SMO/BRAF Inhibition by Flavonolignans from <i>Silybum marianum</i>

Dual SMO/BRAF Inhibition by Flavonolignans from <i>Silybum marianum</i>

Silymarin is the standardized extract from the fruits of <i>Silybum marianum</i> (L.) Gaertn., a well-known hepatoprotectant and antioxidant. Recently, bioactive compounds of silymarin, i.e., silybins and their 2,3-dehydro derivatives, have been shown to exert anticancer activities, yet...

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Bibliographic Details
Main Authors: Antonia Diukendjieva, Maya M. Zaharieva, Mattia Mori, Petko Alov, Ivanka Tsakovska, Tania Pencheva, Hristo Najdenski, Vladimír Křen, Chiara Felici, Francesca Bufalieri, Lucia Di Marcotullio, Bruno Botta, Maurizio Botta, Ilza Pajeva
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Antioxidants
Subjects:
silybins
BRAF kinase
Smoothened
in silico methods
cytotoxicity
Online Access:https://www.mdpi.com/2076-3921/9/5/384

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