<i>FADS</i> Polymorphisms Affect the Clinical and Biochemical Phenotypes of Metabolic Syndrome
Long-chain polyunsaturated fatty acids (LC-PUFAs) play important roles in human health, from controlling inflammation to lipid and glucose homeostasis. In our previous study, which employed a cluster analysis of a plasma fatty acid (FA) pattern, we identified two clusters of metabolic syndrome (MetS...
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MDPI AG
2022-06-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/6/568 |
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| author | Aleš Žák Marie Jáchymová Michal Burda Barbora Staňková Miroslav Zeman Adolf Slabý Marek Vecka Ondřej Šeda |
| author_facet | Aleš Žák Marie Jáchymová Michal Burda Barbora Staňková Miroslav Zeman Adolf Slabý Marek Vecka Ondřej Šeda |
| author_sort | Aleš Žák |
| collection | DOAJ |
| description | Long-chain polyunsaturated fatty acids (LC-PUFAs) play important roles in human health, from controlling inflammation to lipid and glucose homeostasis. In our previous study, which employed a cluster analysis of a plasma fatty acid (FA) pattern, we identified two clusters of metabolic syndrome (MetS) independent of clinical and biochemical parameters within the whole study group (controls together with metabolic syndrome (MetS) patients). FA desaturase (<i>FADS</i>) genes are the key regulators of LC-PUFA metabolism. The aim of this study was to analyze associations between <i>FADS</i> polymorphisms and clusters of MetS. The study group consisted of 188 controls and 166 patients with MetS. The first cluster contained 71 controls (CON1) and 109 MetS patients (MetS1). The second cluster consisted of 117 controls (CON2) and 57 MetS patients (MetS2). In comparison with MetS2, cluster MetS1 displayed a more adverse risk profile. Cluster CON1 had, in comparison with CON2, higher body weight and increased triacylglycerol levels (<i>p</i> < 0.05). We found that the <i>FADS</i> rs174537 (<i>p</i> < 0.001), rs174570 (<i>p</i> < 0.01), and rs174602 (<i>p</i> < 0.05) polymorphisms along with two inferred haplotypes had statistically significant genotype associations with the splitting of MetS into MetS1 and MetS2. Conversely, we observed no significant differences in the distribution of <i>FADS</i> polymorphisms between MetS and CON subjects, or between CON1 and CON2. These associations between <i>FADS</i> polymorphisms and two clusters of MetS (differing in waist circumference, HOMA-IR, lipolysis, and oxidative stress) implicate the important influence of genetic factors on the phenotypic manifestation of MetS. |
| first_indexed | 2024-03-09T23:03:53Z |
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| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T23:03:53Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-551dec8948fd48018e5e5f692ff2e1082023-11-23T17:56:49ZengMDPI AGMetabolites2218-19892022-06-0112656810.3390/metabo12060568<i>FADS</i> Polymorphisms Affect the Clinical and Biochemical Phenotypes of Metabolic SyndromeAleš Žák0Marie Jáchymová1Michal Burda2Barbora Staňková3Miroslav Zeman4Adolf Slabý5Marek Vecka6Ondřej Šeda74th Department of Medicine, 1st Medical Faculty, Charles University and the General University Hospital in Prague, 128 08 Prague, Czech RepublicInstitute of Clinical Chemistry and Laboratory Diagnostics, 1st Medical Faculty, Charles University and the General University Hospital in Prague, 128 08 Prague, Czech RepublicInstitute for Research and Applications of Fuzzy Modeling, University of Ostrava, 701 03 Ostrava, Czech Republic4th Department of Medicine, 1st Medical Faculty, Charles University and the General University Hospital in Prague, 128 08 Prague, Czech Republic4th Department of Medicine, 1st Medical Faculty, Charles University and the General University Hospital in Prague, 128 08 Prague, Czech Republic4th Department of Medicine, 1st Medical Faculty, Charles University and the General University Hospital in Prague, 128 08 Prague, Czech Republic4th Department of Medicine, 1st Medical Faculty, Charles University and the General University Hospital in Prague, 128 08 Prague, Czech RepublicInstitute of Biology and Medical Genetics, 1st Medical Faculty, Charles University and the General University Hospital in Prague, 128 00 Prague, Czech RepublicLong-chain polyunsaturated fatty acids (LC-PUFAs) play important roles in human health, from controlling inflammation to lipid and glucose homeostasis. In our previous study, which employed a cluster analysis of a plasma fatty acid (FA) pattern, we identified two clusters of metabolic syndrome (MetS) independent of clinical and biochemical parameters within the whole study group (controls together with metabolic syndrome (MetS) patients). FA desaturase (<i>FADS</i>) genes are the key regulators of LC-PUFA metabolism. The aim of this study was to analyze associations between <i>FADS</i> polymorphisms and clusters of MetS. The study group consisted of 188 controls and 166 patients with MetS. The first cluster contained 71 controls (CON1) and 109 MetS patients (MetS1). The second cluster consisted of 117 controls (CON2) and 57 MetS patients (MetS2). In comparison with MetS2, cluster MetS1 displayed a more adverse risk profile. Cluster CON1 had, in comparison with CON2, higher body weight and increased triacylglycerol levels (<i>p</i> < 0.05). We found that the <i>FADS</i> rs174537 (<i>p</i> < 0.001), rs174570 (<i>p</i> < 0.01), and rs174602 (<i>p</i> < 0.05) polymorphisms along with two inferred haplotypes had statistically significant genotype associations with the splitting of MetS into MetS1 and MetS2. Conversely, we observed no significant differences in the distribution of <i>FADS</i> polymorphisms between MetS and CON subjects, or between CON1 and CON2. These associations between <i>FADS</i> polymorphisms and two clusters of MetS (differing in waist circumference, HOMA-IR, lipolysis, and oxidative stress) implicate the important influence of genetic factors on the phenotypic manifestation of MetS.https://www.mdpi.com/2218-1989/12/6/568metabolic syndromefatty acid patterncluster analysissingle-nucleotide polymorphismhaplotypes<i>FADS1</i> |
| spellingShingle | Aleš Žák Marie Jáchymová Michal Burda Barbora Staňková Miroslav Zeman Adolf Slabý Marek Vecka Ondřej Šeda <i>FADS</i> Polymorphisms Affect the Clinical and Biochemical Phenotypes of Metabolic Syndrome Metabolites metabolic syndrome fatty acid pattern cluster analysis single-nucleotide polymorphism haplotypes <i>FADS1</i> |
| title | <i>FADS</i> Polymorphisms Affect the Clinical and Biochemical Phenotypes of Metabolic Syndrome |
| title_full | <i>FADS</i> Polymorphisms Affect the Clinical and Biochemical Phenotypes of Metabolic Syndrome |
| title_fullStr | <i>FADS</i> Polymorphisms Affect the Clinical and Biochemical Phenotypes of Metabolic Syndrome |
| title_full_unstemmed | <i>FADS</i> Polymorphisms Affect the Clinical and Biochemical Phenotypes of Metabolic Syndrome |
| title_short | <i>FADS</i> Polymorphisms Affect the Clinical and Biochemical Phenotypes of Metabolic Syndrome |
| title_sort | i fads i polymorphisms affect the clinical and biochemical phenotypes of metabolic syndrome |
| topic | metabolic syndrome fatty acid pattern cluster analysis single-nucleotide polymorphism haplotypes <i>FADS1</i> |
| url | https://www.mdpi.com/2218-1989/12/6/568 |
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