Thalamic shape abnormalities in antipsychotic naïve schizophrenia
Background: Neurodevelopmental hypothesis of schizophrenia states abnormal pruning as one of the pathogenetic mechanism in schizophrenia. Though thalamic volume abnormalities have been documented, the shape differences of thalamus in antipsychotic-free schizophrenia in comparison with age- and sex-m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2013-01-01
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| Series: | Indian Journal of Psychological Medicine |
| Subjects: | |
| Online Access: | http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=1;spage=34;epage=38;aulast=Danivas |
| _version_ | 1818717646229602304 |
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| author | Vijay Danivas Sunil V Kalmady Ganesan Venkatasubramanian Bangalore N Gangadhar |
| author_facet | Vijay Danivas Sunil V Kalmady Ganesan Venkatasubramanian Bangalore N Gangadhar |
| author_sort | Vijay Danivas |
| collection | DOAJ |
| description | Background: Neurodevelopmental hypothesis of schizophrenia states abnormal pruning as one of the pathogenetic mechanism in schizophrenia. Though thalamic volume abnormalities have been documented, the shape differences of thalamus in antipsychotic-free schizophrenia in comparison with age- and sex-matched healthy volunteers need validation. Materials and Methods: We examined antipsychotic naïve schizophrenia patients ( n=60) and age- and sex-matched healthy volunteers ( n=44). The thalamic shape abnormalities were analyzed from their coded structural magnetic resonance imaging (MRI) data using three-dimensional automated image analysis software, FMRIB′s (Oxford Center for the functional MRI of the brain) tools-FIRST (FMRIB′s Integrated Registration and Segmentation Tool) by creating deformable mesh model. Correlation with the psychopathology scores was carried out using F-statistics. Results: Patients with schizophrenia showed significant inward deformations in the regions corresponding to anterior, ventromedial, mediodorsal, and pulvinar nuclei. There was a direct correlation between negative syndrome score and the deformation in the right mediodorsal and right pulvinar nuclei. Conclusion: The inward deformations of thalamus in antipsychotic naive schizophrenia patients correspond to those nuclei which have reciprocal connections with frontal, superior temporal, and anterior cingulate regions and support the neurodevelopmental hypothesis of schizophrenia. |
| first_indexed | 2024-12-17T19:38:27Z |
| format | Article |
| id | doaj.art-551dff177fde46b5b35adc966ea0fe7a |
| institution | Directory Open Access Journal |
| issn | 0253-7176 |
| language | English |
| last_indexed | 2024-12-17T19:38:27Z |
| publishDate | 2013-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Psychological Medicine |
| spelling | doaj.art-551dff177fde46b5b35adc966ea0fe7a2022-12-21T21:35:06ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71762013-01-01351343810.4103/0253-7176.112198Thalamic shape abnormalities in antipsychotic naïve schizophreniaVijay DanivasSunil V KalmadyGanesan VenkatasubramanianBangalore N GangadharBackground: Neurodevelopmental hypothesis of schizophrenia states abnormal pruning as one of the pathogenetic mechanism in schizophrenia. Though thalamic volume abnormalities have been documented, the shape differences of thalamus in antipsychotic-free schizophrenia in comparison with age- and sex-matched healthy volunteers need validation. Materials and Methods: We examined antipsychotic naïve schizophrenia patients ( n=60) and age- and sex-matched healthy volunteers ( n=44). The thalamic shape abnormalities were analyzed from their coded structural magnetic resonance imaging (MRI) data using three-dimensional automated image analysis software, FMRIB′s (Oxford Center for the functional MRI of the brain) tools-FIRST (FMRIB′s Integrated Registration and Segmentation Tool) by creating deformable mesh model. Correlation with the psychopathology scores was carried out using F-statistics. Results: Patients with schizophrenia showed significant inward deformations in the regions corresponding to anterior, ventromedial, mediodorsal, and pulvinar nuclei. There was a direct correlation between negative syndrome score and the deformation in the right mediodorsal and right pulvinar nuclei. Conclusion: The inward deformations of thalamus in antipsychotic naive schizophrenia patients correspond to those nuclei which have reciprocal connections with frontal, superior temporal, and anterior cingulate regions and support the neurodevelopmental hypothesis of schizophrenia.http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=1;spage=34;epage=38;aulast=DanivasSchizophreniashape abnormalitythalamus |
| spellingShingle | Vijay Danivas Sunil V Kalmady Ganesan Venkatasubramanian Bangalore N Gangadhar Thalamic shape abnormalities in antipsychotic naïve schizophrenia Indian Journal of Psychological Medicine Schizophrenia shape abnormality thalamus |
| title | Thalamic shape abnormalities in antipsychotic naïve schizophrenia |
| title_full | Thalamic shape abnormalities in antipsychotic naïve schizophrenia |
| title_fullStr | Thalamic shape abnormalities in antipsychotic naïve schizophrenia |
| title_full_unstemmed | Thalamic shape abnormalities in antipsychotic naïve schizophrenia |
| title_short | Thalamic shape abnormalities in antipsychotic naïve schizophrenia |
| title_sort | thalamic shape abnormalities in antipsychotic naive schizophrenia |
| topic | Schizophrenia shape abnormality thalamus |
| url | http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=1;spage=34;epage=38;aulast=Danivas |
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