Targeting PGM3 as a Novel Therapeutic Strategy in <i>KRAS/LKB1</i> Co-Mutant Lung Cancer

Targeting PGM3 as a Novel Therapeutic Strategy in <i>KRAS/LKB1</i> Co-Mutant Lung Cancer

In non-small-cell lung cancer (NSCLC), concurrent mutations in the oncogene <i>KRAS</i> and tumor suppressor <i>STK11</i> (also known as LKB1) confer an aggressive malignant phenotype, an unfavourability towards immunotherapy, and overall poor prognoses in patients. In a prev...

Full description

Bibliographic Details
Main Authors:	Hyunmin Lee, Feng Cai, Neil Kelekar, Nipun K. Velupally, Jiyeon Kim
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Series:	Cells
Subjects:	cancer metabolism metabolic vulnerability non-small cell lung cancer <i>KRAS</i> and <i>LKB1</i> co-mutations the hexosamine biosynthesis pathway glycosylation
Online Access:	https://www.mdpi.com/2073-4409/11/1/176

Similar Items

<i>STK11/LKB1</i> Modulation of the Immune Response in Lung Cancer: From Biology to Therapeutic Impact
by: Elvire Pons-Tostivint, et al.
Published: (2021-11-01)

Caloric restriction and metformin selectively improved LKB1-mutated NSCLC tumor response to chemo- and chemo-immunotherapy
by: Gloriana Ndembe, et al.
Published: (2024-01-01)

The Importance of <i>STK11</i>/<i>LKB1</i> Assessment in Non-Small Cell Lung Carcinomas
by: Baharia Mograbi, et al.
Published: (2021-01-01)

Suppression of the HBP Function Increases Pancreatic Cancer Cell Sensitivity to a Pan-RAS Inhibitor
by: Francesca Ricciardiello, et al.
Published: (2021-02-01)

The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring
by: Ferdinando Chiaradonna, et al.
Published: (2018-06-01)

Current knowledge and potential intervention of hexosamine biosynthesis pathway in lung cancer
by: Yi Zou, et al.
Published: (2023-10-01)

Eicosapentaenoic Acid Inhibits <i>KRAS</i> Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation
by: Ching-Feng Chiu, et al.
Published: (2021-03-01)

Characterization of <i>Gfat1</i> (<i>zeppelin</i>) and <i>Gfat2</i>, Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate-Limiting Step in the Hexosamine Biosynthetic Pathway in <i>Drosophila melanogaster</i>
by: Shawn Cotsworth, et al.
Published: (2022-01-01)

Clinicopathological Characteristics and Mutational Landscape of <i>APC</i>, <i>HOXB13,</i> and <i>KRAS</i> among Rwandan Patients with Colorectal Cancer
by: Felix Manirakiza, et al.
Published: (2023-05-01)

Targeting KRAS: from metabolic regulation to cancer treatment
by: Yanyan Shi, et al.
Published: (2025-01-01)

<i>KRAS</i> Affects the Lipid Composition by Regulating Mitochondrial Functions and MAPK Activation in Bovine Mammary Epithelial Cells
by: Wenjie Yu, et al.
Published: (2022-11-01)

Case report of metastatic colorectal cancer associated with <i>KRAS</i> A146V and A59G mutations
by: O. I. Kit, et al.
Published: (2023-07-01)

Protein <i>O</i>-GlcNAcylation in Metabolic Modulation of Skeletal Muscle: A Bright but Long Way to Go
by: Yang Liu, et al.
Published: (2022-09-01)

Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
by: Meng Qiao, et al.
Published: (2024-01-01)

Association of <i>KRAS</i> G12C Status with Age at Onset of Metastatic Colorectal Cancer
by: Marcelo Sunagua Aruquipa, et al.
Published: (2024-02-01)

<i>Let-7g</i> Upregulation Attenuated the KRAS–PI3K–Rac1–Akt Axis-Mediated Bioenergetic Functions
by: Kuang-Chen Hung, et al.
Published: (2023-09-01)

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progression
by: Jian Kang, et al.
Published: (2024-10-01)

The Tumor Suppressor Kinase LKB1: Metabolic Nexus
by: Mohammed Bourouh, et al.
Published: (2022-04-01)

Noncoding RNA Profile in Reovirus Treated <i>KRAS</i>-Mutated Colorectal Cancer Patients
by: Rafael Saperstein, et al.
Published: (2023-10-01)

CT-Based Radiomics to Predict <i>KRAS</i> Mutation in CRC Patients Using a Machine Learning Algorithm: A Retrospective Study
by: Jacobo Porto-Álvarez, et al.
Published: (2023-07-01)

<i>KRAS</i> Mutational Profiles among Colorectal Cancer Patients in the East Coast of Peninsular Malaysia
by: Hidayati Husainy Hasbullah, et al.
Published: (2023-02-01)

<i>KRAS</i>, <i>NRAS</i>, and <i>BRAF</i> Hot-Spot Mutations in Relation to Sidedness of Primary Colorectal Cancer: A Retrospective Cohort Study
by: Omer Abdelgadir, et al.
Published: (2025-01-01)

Active Compound of <i>Pharbitis</i> Semen (<i>Pharbitis nil</i> Seeds) Suppressed KRAS-Driven Colorectal Cancer and Restored Muscle Cell Function during Cancer Progression
by: Jisu Song, et al.
Published: (2020-06-01)

Metformin combined with CB-839 specifically inhibits KRAS-mutant ovarian cancer
by: Han Wu, et al.
Published: (2025-02-01)

Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1
by: Ashwini S. Nagaraj, et al.
Published: (2017-01-01)

KRAS Mutation Status in Relation to Clinicopathological Characteristics of Romanian Colorectal Cancer Patients
by: Elena-Roxana Avădănei, et al.
Published: (2025-02-01)

<i>KRAS</i> and <i>BRAF</i> Mutations as Prognostic and Predictive Biomarkers for Standard Chemotherapy Response in Metastatic Colorectal Cancer: A Single Institutional Study
by: Nuria Garcia-Carbonero, et al.
Published: (2020-01-01)

Prognostic Role of <i>KRAS G12C</i> Mutation in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
by: Durgesh Wankhede, et al.
Published: (2023-09-01)

Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers
by: Kenneth E. Huffman, et al.
Published: (2023-03-01)

Abnormalities in the KRAS Gene and Treatment Options for NSCLC Patients with the G12C Mutation in This Gene—A Literature Review and Single-Center Experience
by: Anna K. Rekowska, et al.
Published: (2024-01-01)

KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications
by: Flávia Pereira, et al.
Published: (2022-01-01)

MiR-216b inhibits pancreatic cancer cell progression and promotes apoptosis by down-regulating KRAS
by: Xinquan Wu, et al.
Published: (2017-12-01)

Association between <i>KRAS</i> and <i>PIK3CA</i> Mutations and Progesterone Resistance in Endometriotic Epithelial Cell Line
by: Kosuke Kanno, et al.
Published: (2024-04-01)

Evaluation of AMG510 Therapy on <i>KRAS</i>-Mutant Non–Small Cell Lung Cancer and Colorectal Cancer Cell Using a 3D Invasive Tumor Spheroid System under Normoxia and Hypoxia
by: Meng Huang, et al.
Published: (2022-12-01)

Influence of O-GlcNAcylation on KGN cell function
by: Abigail M. Maucieri, et al.
Published: (2024-09-01)

Diabetic Embryopathy Susceptibility in Mice Is Associated with Differential Dependence on Glucosamine and Modulation of High Glucose-Induced Oxidative Stress
by: Jin Hyuk Jung, et al.
Published: (2021-07-01)

A Case of Non-Small Cell Lung Cancer with Mutually Exclusive <i>EGFR</i> and <i>KRAS</i> Mutations
by: Abhimanyu Tushir, et al.
Published: (2025-01-01)

LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases
by: Yanghe Zhang, et al.
Published: (2021-02-01)

Crucial Role of Oncogenic <i>KRAS</i> Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications
by: Anabela Ferreira, et al.
Published: (2022-07-01)

Metabolic Engineering of <i>Bacillus subtilis</i> for Riboflavin Production: A Review
by: Yang Liu, et al.
Published: (2023-01-01)