SARS-CoV-2 S-RBD IgG & Neutralizing antibodies among different categories of health care workers post third dose BNT162b2 mRNA COVID-19 vaccine
Neutralizing antibodies (NTAb) play a significant role in preventing and protecting against SARS-CoV-2 virus infection. Identifying NTAb is undoubtedly imperative in understanding the immunity toward COVID-19 better. However, it is interesting to note that the production of NTAb varies among individ...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2023.2266931 |
| _version_ | 1827767364237656064 |
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| author | Wan Muhammad Azfar Wan Shuaib Izzatul Aliaa Badaruddin Munirah Mansor Sharifah Azura Salleh Mohd Rohaizat Hassan Steward Lindong Shahril Nizam Samad Hanita Othman |
| author_facet | Wan Muhammad Azfar Wan Shuaib Izzatul Aliaa Badaruddin Munirah Mansor Sharifah Azura Salleh Mohd Rohaizat Hassan Steward Lindong Shahril Nizam Samad Hanita Othman |
| author_sort | Wan Muhammad Azfar Wan Shuaib |
| collection | DOAJ |
| description | Neutralizing antibodies (NTAb) play a significant role in preventing and protecting against SARS-CoV-2 virus infection. Identifying NTAb is undoubtedly imperative in understanding the immunity toward COVID-19 better. However, it is interesting to note that the production of NTAb varies among individuals, especially among healthcare workers (HCWs), as they are exposed to the virus daily. Hence, we would like to investigate factors affecting the production of S-RBD IgG and NTAb among different categories of HCWs, particularly after receiving the third dose of the BNT162b2 mRNA COVID-19 Vaccine. A total of 361 HCWs from our hospital were prospectively enrolled and had their S-RBD IgG and NTAb titers measured. They were studied in relation to the degree of exposure to COVID-19, breakthrough infections, gender, age, race, household income, housing type, household number, and education levels. HCWs with the highest risk of exposure to COVID-19, breakthrough infections, and male gender displayed the highest median titers of both S-RBD IgG and NTAb, and the differences were statistically significant (p < .05). Age, race, household income, housing type, household number, and education levels were revealed to be insignificant. We concluded that the degree of exposure to COVID-19, breakthrough infections, and male gender are significant factors in NTAb production among HCWs. |
| first_indexed | 2024-03-11T11:57:43Z |
| format | Article |
| id | doaj.art-552257fe2401494db5a4598422b340ad |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T11:57:43Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-552257fe2401494db5a4598422b340ad2023-11-08T11:55:20ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2023-12-0119310.1080/21645515.2023.22669312266931SARS-CoV-2 S-RBD IgG & Neutralizing antibodies among different categories of health care workers post third dose BNT162b2 mRNA COVID-19 vaccineWan Muhammad Azfar Wan Shuaib0Izzatul Aliaa Badaruddin1Munirah Mansor2Sharifah Azura Salleh3Mohd Rohaizat Hassan4Steward Lindong5Shahril Nizam Samad6Hanita Othman7Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz, UKMMCUniversiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz, UKMMCHospital Canselor Tuanku Muhriz, UKMMCUniversiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz, UKMMCUniversiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz, UKMMCHospital Canselor Tuanku Muhriz, UKMMCHospital Canselor Tuanku Muhriz, UKMMCUniversiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz, UKMMCNeutralizing antibodies (NTAb) play a significant role in preventing and protecting against SARS-CoV-2 virus infection. Identifying NTAb is undoubtedly imperative in understanding the immunity toward COVID-19 better. However, it is interesting to note that the production of NTAb varies among individuals, especially among healthcare workers (HCWs), as they are exposed to the virus daily. Hence, we would like to investigate factors affecting the production of S-RBD IgG and NTAb among different categories of HCWs, particularly after receiving the third dose of the BNT162b2 mRNA COVID-19 Vaccine. A total of 361 HCWs from our hospital were prospectively enrolled and had their S-RBD IgG and NTAb titers measured. They were studied in relation to the degree of exposure to COVID-19, breakthrough infections, gender, age, race, household income, housing type, household number, and education levels. HCWs with the highest risk of exposure to COVID-19, breakthrough infections, and male gender displayed the highest median titers of both S-RBD IgG and NTAb, and the differences were statistically significant (p < .05). Age, race, household income, housing type, household number, and education levels were revealed to be insignificant. We concluded that the degree of exposure to COVID-19, breakthrough infections, and male gender are significant factors in NTAb production among HCWs.http://dx.doi.org/10.1080/21645515.2023.2266931sars-cov-2covid-19neutralizing antibodieshealthcare workersbnt162b2 |
| spellingShingle | Wan Muhammad Azfar Wan Shuaib Izzatul Aliaa Badaruddin Munirah Mansor Sharifah Azura Salleh Mohd Rohaizat Hassan Steward Lindong Shahril Nizam Samad Hanita Othman SARS-CoV-2 S-RBD IgG & Neutralizing antibodies among different categories of health care workers post third dose BNT162b2 mRNA COVID-19 vaccine Human Vaccines & Immunotherapeutics sars-cov-2 covid-19 neutralizing antibodies healthcare workers bnt162b2 |
| title | SARS-CoV-2 S-RBD IgG & Neutralizing antibodies among different categories of health care workers post third dose BNT162b2 mRNA COVID-19 vaccine |
| title_full | SARS-CoV-2 S-RBD IgG & Neutralizing antibodies among different categories of health care workers post third dose BNT162b2 mRNA COVID-19 vaccine |
| title_fullStr | SARS-CoV-2 S-RBD IgG & Neutralizing antibodies among different categories of health care workers post third dose BNT162b2 mRNA COVID-19 vaccine |
| title_full_unstemmed | SARS-CoV-2 S-RBD IgG & Neutralizing antibodies among different categories of health care workers post third dose BNT162b2 mRNA COVID-19 vaccine |
| title_short | SARS-CoV-2 S-RBD IgG & Neutralizing antibodies among different categories of health care workers post third dose BNT162b2 mRNA COVID-19 vaccine |
| title_sort | sars cov 2 s rbd igg neutralizing antibodies among different categories of health care workers post third dose bnt162b2 mrna covid 19 vaccine |
| topic | sars-cov-2 covid-19 neutralizing antibodies healthcare workers bnt162b2 |
| url | http://dx.doi.org/10.1080/21645515.2023.2266931 |
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