Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study
The placenta undergoes reconstruction at different times during fetal development to supply oxygen and nutrients required throughout pregnancy. To accommodate the rapid growth of the fetus, small spiral arteries undergo remodeling in the placenta. This remodeling includes apoptosis of endothelial ce...
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/19/7235 |
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| author | Soon-Young Kim Eun-Hye Lee Eun Na Kim Woo-Chan Son Yeo Hyang Kim Seung-Yoon Park In-San Kim Jung-Eun Kim |
| author_facet | Soon-Young Kim Eun-Hye Lee Eun Na Kim Woo-Chan Son Yeo Hyang Kim Seung-Yoon Park In-San Kim Jung-Eun Kim |
| author_sort | Soon-Young Kim |
| collection | DOAJ |
| description | The placenta undergoes reconstruction at different times during fetal development to supply oxygen and nutrients required throughout pregnancy. To accommodate the rapid growth of the fetus, small spiral arteries undergo remodeling in the placenta. This remodeling includes apoptosis of endothelial cells that line spiral arteries, which are replaced by trophoblasts of fetal origin. Removal of dead cells is critical during this process. Stabilin-1 (Stab1) and stabilin-2 (Stab2) are important receptors expressed on scavenger cells that absorb and degrade apoptotic cells, and Stab1 is expressed in specific cells of the placenta. However, the role of Stab1 and Stab2 in placental development and maintenance remain unclear. In this study, we assessed Stab1 and Stab2 expression in the placenta and examined the reproductive capacity and placental development using a double-knockout mouse strain lacking both Stab1 and Stab2 (Stab1/2 dKO mice). Most pregnant Stab1/2 dKO female mice did not produce offspring and exhibited placental defects, including decidual hemorrhage and necrosis. Findings of this study offer the first description of the phenotypic characteristics of placentas and embryos of Stab1/2 dKO females during pregnancy, suggesting that Stab1 and Stab2 are involved in placental development and maintenance. |
| first_indexed | 2024-03-10T15:55:50Z |
| format | Article |
| id | doaj.art-55225907287c4a369ffb8a880e773ca3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:55:50Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-55225907287c4a369ffb8a880e773ca32023-11-20T15:42:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012119723510.3390/ijms21197235Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive StudySoon-Young Kim0Eun-Hye Lee1Eun Na Kim2Woo-Chan Son3Yeo Hyang Kim4Seung-Yoon Park5In-San Kim6Jung-Eun Kim7Department of Molecular Medicine, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, KoreaDepartment of Molecular Medicine, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, KoreaDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41944, KoreaDepartment of Biochemistry, School of Medicine, Dongguk University, Gyeongju 38066, KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, KoreaDepartment of Molecular Medicine, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, KoreaThe placenta undergoes reconstruction at different times during fetal development to supply oxygen and nutrients required throughout pregnancy. To accommodate the rapid growth of the fetus, small spiral arteries undergo remodeling in the placenta. This remodeling includes apoptosis of endothelial cells that line spiral arteries, which are replaced by trophoblasts of fetal origin. Removal of dead cells is critical during this process. Stabilin-1 (Stab1) and stabilin-2 (Stab2) are important receptors expressed on scavenger cells that absorb and degrade apoptotic cells, and Stab1 is expressed in specific cells of the placenta. However, the role of Stab1 and Stab2 in placental development and maintenance remain unclear. In this study, we assessed Stab1 and Stab2 expression in the placenta and examined the reproductive capacity and placental development using a double-knockout mouse strain lacking both Stab1 and Stab2 (Stab1/2 dKO mice). Most pregnant Stab1/2 dKO female mice did not produce offspring and exhibited placental defects, including decidual hemorrhage and necrosis. Findings of this study offer the first description of the phenotypic characteristics of placentas and embryos of Stab1/2 dKO females during pregnancy, suggesting that Stab1 and Stab2 are involved in placental development and maintenance.https://www.mdpi.com/1422-0067/21/19/7235Stabilin-1Stabilin-2double knockoutplacentadeciduahemorrhage |
| spellingShingle | Soon-Young Kim Eun-Hye Lee Eun Na Kim Woo-Chan Son Yeo Hyang Kim Seung-Yoon Park In-San Kim Jung-Eun Kim Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study International Journal of Molecular Sciences Stabilin-1 Stabilin-2 double knockout placenta decidua hemorrhage |
| title | Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study |
| title_full | Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study |
| title_fullStr | Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study |
| title_full_unstemmed | Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study |
| title_short | Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study |
| title_sort | identifying stabilin 1 and stabilin 2 double knockouts in reproduction and placentation a descriptive study |
| topic | Stabilin-1 Stabilin-2 double knockout placenta decidua hemorrhage |
| url | https://www.mdpi.com/1422-0067/21/19/7235 |
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