A brief history of liver transplantation and transplant anesthesia
Abstract In this review, we describe the major milestones in the development of organ transplantation with a specific focus on hepatic transplantation. For many years, the barriers preventing successful organ transplantation in humans seemed insurmountable. Although advances in surgical technique pr...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Anesthesiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12871-022-01904-1 |
| _version_ | 1811187070741250048 |
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| author | Sonal Sharma Fuat H. Saner Dmitri Bezinover |
| author_facet | Sonal Sharma Fuat H. Saner Dmitri Bezinover |
| author_sort | Sonal Sharma |
| collection | DOAJ |
| description | Abstract In this review, we describe the major milestones in the development of organ transplantation with a specific focus on hepatic transplantation. For many years, the barriers preventing successful organ transplantation in humans seemed insurmountable. Although advances in surgical technique provided the technical ability to perform organ transplantation, limited understanding of immunology prevented successful organ transplantation. The breakthrough to success was the result of several significant discoveries between 1950 and 1980 involving improved surgical techniques, the development of effective preservative solutions, and the suppression of cellular immunity to prevent graft rejection. After that, technical innovations and laboratory and clinical research developed rapidly. However, these advances alone could not have led to improved transplant outcomes without parallel advances in anesthesia and critical care. With increasing organ demand, it proved necessary to expand the donor pool, which has been achieved with the use of living donors, split grafts, extended criteria organs, and organs obtained through donation after cardiac death. Given this increased access to organs and organ resources, the number of transplantations performed every year has increased dramatically. New regulatory organizations and transplant societies provide critical oversight to ensure equitable organ distribution and a high standard of care and also perform outcome analyses. Establishing dedicated transplant anesthesia teams results in improved organ transplantation outcomes and provides a foundation for developing new standards for other subspecialties in anesthesiology, critical care, and medicine overall. Through a century of discovery, the success we enjoy at the present time is the result of the work of well-organized multidisciplinary teams following standardized protocols and thereby saving thousands of lives worldwide each year. With continuing innovation, the future is bright. |
| first_indexed | 2024-04-11T13:55:52Z |
| format | Article |
| id | doaj.art-5523bf6248fb413c91c7b0c542d10f40 |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-04-11T13:55:52Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-5523bf6248fb413c91c7b0c542d10f402022-12-22T04:20:20ZengBMCBMC Anesthesiology1471-22532022-11-0122111210.1186/s12871-022-01904-1A brief history of liver transplantation and transplant anesthesiaSonal Sharma0Fuat H. Saner1Dmitri Bezinover2Department of Anesthesiology and Perioperative Medicine, Pennsylvania State UniversityDepartment of General, Visceral, and Transplant Surgery, Medical Center University EssenDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of PennsylvaniaAbstract In this review, we describe the major milestones in the development of organ transplantation with a specific focus on hepatic transplantation. For many years, the barriers preventing successful organ transplantation in humans seemed insurmountable. Although advances in surgical technique provided the technical ability to perform organ transplantation, limited understanding of immunology prevented successful organ transplantation. The breakthrough to success was the result of several significant discoveries between 1950 and 1980 involving improved surgical techniques, the development of effective preservative solutions, and the suppression of cellular immunity to prevent graft rejection. After that, technical innovations and laboratory and clinical research developed rapidly. However, these advances alone could not have led to improved transplant outcomes without parallel advances in anesthesia and critical care. With increasing organ demand, it proved necessary to expand the donor pool, which has been achieved with the use of living donors, split grafts, extended criteria organs, and organs obtained through donation after cardiac death. Given this increased access to organs and organ resources, the number of transplantations performed every year has increased dramatically. New regulatory organizations and transplant societies provide critical oversight to ensure equitable organ distribution and a high standard of care and also perform outcome analyses. Establishing dedicated transplant anesthesia teams results in improved organ transplantation outcomes and provides a foundation for developing new standards for other subspecialties in anesthesiology, critical care, and medicine overall. Through a century of discovery, the success we enjoy at the present time is the result of the work of well-organized multidisciplinary teams following standardized protocols and thereby saving thousands of lives worldwide each year. With continuing innovation, the future is bright.https://doi.org/10.1186/s12871-022-01904-1Liver transplantationTransplant anesthesiaTransplantation societies |
| spellingShingle | Sonal Sharma Fuat H. Saner Dmitri Bezinover A brief history of liver transplantation and transplant anesthesia BMC Anesthesiology Liver transplantation Transplant anesthesia Transplantation societies |
| title | A brief history of liver transplantation and transplant anesthesia |
| title_full | A brief history of liver transplantation and transplant anesthesia |
| title_fullStr | A brief history of liver transplantation and transplant anesthesia |
| title_full_unstemmed | A brief history of liver transplantation and transplant anesthesia |
| title_short | A brief history of liver transplantation and transplant anesthesia |
| title_sort | brief history of liver transplantation and transplant anesthesia |
| topic | Liver transplantation Transplant anesthesia Transplantation societies |
| url | https://doi.org/10.1186/s12871-022-01904-1 |
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