Evaluation of Depth of Invasion in Oral Squamous Cell Carcinoma with Ultra-High Frequency Ultrasound: A Preliminary Study
Intraoral ultrasonography has been widely employed for the preoperative assessment of tumor margins due to its capability to evaluate depth of invasion (DOI) and tumor thickness (TT). Recently, a novel ultrasonographic technique, ultra-high frequency ultrasound (UHFUS) has been increasingly applied...
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MDPI AG
2021-08-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/16/7647 |
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| author | Rossana Izzetti Marco Nisi Stefano Gennai Teresa Oranges Laura Crocetti Davide Caramella Filippo Graziani |
| author_facet | Rossana Izzetti Marco Nisi Stefano Gennai Teresa Oranges Laura Crocetti Davide Caramella Filippo Graziani |
| author_sort | Rossana Izzetti |
| collection | DOAJ |
| description | Intraoral ultrasonography has been widely employed for the preoperative assessment of tumor margins due to its capability to evaluate depth of invasion (DOI) and tumor thickness (TT). Recently, a novel ultrasonographic technique, ultra-high frequency ultrasound (UHFUS) has been increasingly applied to the study of oral lesions. This study evaluates the potential application of intraoral UHFUS to assess DOI and TT parameters of oral squamous cell carcinoma (OSCC) lesions. Patients clinically suspected of OSCC lesions were enrolled and underwent an intraoral UHFUS examination preoperatively. The parameters of TT, DOI, echogenicity, and vascularization were assessed. The parameters of TT and DOI as evaluated by means of UHFUS were compared to histology, which was set as the benchmark. Ten patients in total were enrolled. UHFUS-based DOI and TT measurements were found to positively correlate with histology (<i>p</i> < 0.05), although UHFUS provided a slight overestimation of DOI. No differences were found in terms of echogenicity or vascularization depending on the site of the lesion. According to these preliminary results, UHFUS could support the preoperative assessment of TT and DOI, potentially enhancing the clinical evaluation of OSCC. |
| first_indexed | 2024-03-10T09:01:18Z |
| format | Article |
| id | doaj.art-55247cc127ae44a2826d65aca09f018f |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T09:01:18Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-55247cc127ae44a2826d65aca09f018f2023-11-22T06:44:50ZengMDPI AGApplied Sciences2076-34172021-08-011116764710.3390/app11167647Evaluation of Depth of Invasion in Oral Squamous Cell Carcinoma with Ultra-High Frequency Ultrasound: A Preliminary StudyRossana Izzetti0Marco Nisi1Stefano Gennai2Teresa Oranges3Laura Crocetti4Davide Caramella5Filippo Graziani6Unit of Dentistry and Oral Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, ItalyUnit of Dentistry and Oral Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, ItalyUnit of Dentistry and Oral Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, ItalyUnit of Dermatology, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyDiagnostic and Interventional Radiology, Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, ItalyDiagnostic and Interventional Radiology, Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, ItalyUnit of Dentistry and Oral Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, ItalyIntraoral ultrasonography has been widely employed for the preoperative assessment of tumor margins due to its capability to evaluate depth of invasion (DOI) and tumor thickness (TT). Recently, a novel ultrasonographic technique, ultra-high frequency ultrasound (UHFUS) has been increasingly applied to the study of oral lesions. This study evaluates the potential application of intraoral UHFUS to assess DOI and TT parameters of oral squamous cell carcinoma (OSCC) lesions. Patients clinically suspected of OSCC lesions were enrolled and underwent an intraoral UHFUS examination preoperatively. The parameters of TT, DOI, echogenicity, and vascularization were assessed. The parameters of TT and DOI as evaluated by means of UHFUS were compared to histology, which was set as the benchmark. Ten patients in total were enrolled. UHFUS-based DOI and TT measurements were found to positively correlate with histology (<i>p</i> < 0.05), although UHFUS provided a slight overestimation of DOI. No differences were found in terms of echogenicity or vascularization depending on the site of the lesion. According to these preliminary results, UHFUS could support the preoperative assessment of TT and DOI, potentially enhancing the clinical evaluation of OSCC.https://www.mdpi.com/2076-3417/11/16/7647oral neoplasmsneoplasm invasivenessneoplasm stagingsquamous cell carcinoma of head and neckdiagnostic imagingultrasonography |
| spellingShingle | Rossana Izzetti Marco Nisi Stefano Gennai Teresa Oranges Laura Crocetti Davide Caramella Filippo Graziani Evaluation of Depth of Invasion in Oral Squamous Cell Carcinoma with Ultra-High Frequency Ultrasound: A Preliminary Study Applied Sciences oral neoplasms neoplasm invasiveness neoplasm staging squamous cell carcinoma of head and neck diagnostic imaging ultrasonography |
| title | Evaluation of Depth of Invasion in Oral Squamous Cell Carcinoma with Ultra-High Frequency Ultrasound: A Preliminary Study |
| title_full | Evaluation of Depth of Invasion in Oral Squamous Cell Carcinoma with Ultra-High Frequency Ultrasound: A Preliminary Study |
| title_fullStr | Evaluation of Depth of Invasion in Oral Squamous Cell Carcinoma with Ultra-High Frequency Ultrasound: A Preliminary Study |
| title_full_unstemmed | Evaluation of Depth of Invasion in Oral Squamous Cell Carcinoma with Ultra-High Frequency Ultrasound: A Preliminary Study |
| title_short | Evaluation of Depth of Invasion in Oral Squamous Cell Carcinoma with Ultra-High Frequency Ultrasound: A Preliminary Study |
| title_sort | evaluation of depth of invasion in oral squamous cell carcinoma with ultra high frequency ultrasound a preliminary study |
| topic | oral neoplasms neoplasm invasiveness neoplasm staging squamous cell carcinoma of head and neck diagnostic imaging ultrasonography |
| url | https://www.mdpi.com/2076-3417/11/16/7647 |
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