Effects of microenvironment and biological behavior on the paracrine function of stem cells
Mesenchymal stem cells (MSCs), the most well-studied cell type in the field of stem cell therapy, have multi-lineage differentiation and self-renewal potential. MSC-based therapies have been used to treat diverse diseases because of their ability to potently repair tissue and locally restore functio...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-01-01
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| Series: | Genes and Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235230422300140X |
| _version_ | 1797745114767949824 |
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| author | Zhixin Xue Yunjun Liao Ye Li |
| author_facet | Zhixin Xue Yunjun Liao Ye Li |
| author_sort | Zhixin Xue |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs), the most well-studied cell type in the field of stem cell therapy, have multi-lineage differentiation and self-renewal potential. MSC-based therapies have been used to treat diverse diseases because of their ability to potently repair tissue and locally restore function. An increasing body of evidence demonstrates that paracrine function is central to the effects of MSC-based therapy. Growth factors, cytokines, chemokines, extracellular matrix components, and extracellular vehicles all contribute to the beneficial effects of MSCs on tissue regeneration and repair. The paracrine substances secreted by MSCs change depending on the tissue microenvironment and biological behavior. In this review, we discuss the bioactive substances secreted by MSCs depending on the microenvironment and biological behavior and their regulatory mechanisms, which explain their potential to treat human diseases, to provide new ideas for further research and clinical cell-free therapy. |
| first_indexed | 2024-03-12T15:18:51Z |
| format | Article |
| id | doaj.art-55252549423e443480ff2c4fb60237d6 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T15:18:51Z |
| publishDate | 2024-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-55252549423e443480ff2c4fb60237d62023-08-11T05:34:55ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422024-01-01111135147Effects of microenvironment and biological behavior on the paracrine function of stem cellsZhixin Xue0Yunjun Liao1Ye Li2The Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, ChinaCorresponding author. Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong 510515, China.; The Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, ChinaCorresponding author. Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong 510515, China.; The Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, ChinaMesenchymal stem cells (MSCs), the most well-studied cell type in the field of stem cell therapy, have multi-lineage differentiation and self-renewal potential. MSC-based therapies have been used to treat diverse diseases because of their ability to potently repair tissue and locally restore function. An increasing body of evidence demonstrates that paracrine function is central to the effects of MSC-based therapy. Growth factors, cytokines, chemokines, extracellular matrix components, and extracellular vehicles all contribute to the beneficial effects of MSCs on tissue regeneration and repair. The paracrine substances secreted by MSCs change depending on the tissue microenvironment and biological behavior. In this review, we discuss the bioactive substances secreted by MSCs depending on the microenvironment and biological behavior and their regulatory mechanisms, which explain their potential to treat human diseases, to provide new ideas for further research and clinical cell-free therapy.http://www.sciencedirect.com/science/article/pii/S235230422300140XBioactive behaviorMesenchymal stem cellsMicroenvironmentParacrineSecretome |
| spellingShingle | Zhixin Xue Yunjun Liao Ye Li Effects of microenvironment and biological behavior on the paracrine function of stem cells Genes and Diseases Bioactive behavior Mesenchymal stem cells Microenvironment Paracrine Secretome |
| title | Effects of microenvironment and biological behavior on the paracrine function of stem cells |
| title_full | Effects of microenvironment and biological behavior on the paracrine function of stem cells |
| title_fullStr | Effects of microenvironment and biological behavior on the paracrine function of stem cells |
| title_full_unstemmed | Effects of microenvironment and biological behavior on the paracrine function of stem cells |
| title_short | Effects of microenvironment and biological behavior on the paracrine function of stem cells |
| title_sort | effects of microenvironment and biological behavior on the paracrine function of stem cells |
| topic | Bioactive behavior Mesenchymal stem cells Microenvironment Paracrine Secretome |
| url | http://www.sciencedirect.com/science/article/pii/S235230422300140X |
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