Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects
The gut barrier monitors and protects the gastrointestinal tract from challenges such as microorganisms, toxins and proteins that could act as antigens. There is evidence that gut barrier dysfunction may act as a primary disease mechanism in intestinal disorders. The aim of the present study was to...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2008-12-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200010 |
| _version_ | 1818253480512454656 |
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| author | E.G. Vilela H.O.G. Torres M.L.A. Ferrari A.S. Lima A.S. Cunha |
| author_facet | E.G. Vilela H.O.G. Torres M.L.A. Ferrari A.S. Lima A.S. Cunha |
| author_sort | E.G. Vilela |
| collection | DOAJ |
| description | The gut barrier monitors and protects the gastrointestinal tract from challenges such as microorganisms, toxins and proteins that could act as antigens. There is evidence that gut barrier dysfunction may act as a primary disease mechanism in intestinal disorders. The aim of the present study was to evaluate the barrier function towards sugars after the appropriate treatment of celiac disease and Crohn's disease patients and compare the results with those obtained with healthy subjects. Fifteen healthy volunteers, 22 celiac disease patients after 1 year of a gluten-free diet, and 31 Crohn's disease patients in remission were submitted to an intestinal permeability test with 6.0 g lactulose and 3.0 g mannitol. Six-hour urinary lactulose excretion in Crohn's disease patients was significantly higher than in both celiac disease patients (0.42 vs 0.15%) and healthy controls (0.42 vs 0.07%). Urinary lactulose excretion was significantly higher in celiac disease patients than in healthy controls (0.15 vs 0.07%). Urinary mannitol excretion in Crohn's disease patients was the same as healthy controls (21 vs 21%) and these values were significantly higher than in celiac disease patients (10.9%). The lactulose/mannitol ratio was significantly higher in Crohn's disease patients in comparison to celiac disease patients (0.021 vs 0.013) and healthy controls (0.021 vs 0.003) and this ratio was also significantly higher in celiac disease patients compared to healthy controls (0.013 vs 0.003). In spite of treatment, differences in sugar permeability were observed in both disease groups. These differences in the behavior of the sugar probes probably reflect different mechanisms for the alterations of intestinal permeability. |
| first_indexed | 2024-12-12T16:40:45Z |
| format | Article |
| id | doaj.art-55255520f43e4aaf800e7eac4ad09788 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-12T16:40:45Z |
| publishDate | 2008-12-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-55255520f43e4aaf800e7eac4ad097882022-12-22T00:18:35ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2008-12-0141121105110910.1590/S0100-879X2008001200010Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjectsE.G. VilelaH.O.G. TorresM.L.A. FerrariA.S. LimaA.S. CunhaThe gut barrier monitors and protects the gastrointestinal tract from challenges such as microorganisms, toxins and proteins that could act as antigens. There is evidence that gut barrier dysfunction may act as a primary disease mechanism in intestinal disorders. The aim of the present study was to evaluate the barrier function towards sugars after the appropriate treatment of celiac disease and Crohn's disease patients and compare the results with those obtained with healthy subjects. Fifteen healthy volunteers, 22 celiac disease patients after 1 year of a gluten-free diet, and 31 Crohn's disease patients in remission were submitted to an intestinal permeability test with 6.0 g lactulose and 3.0 g mannitol. Six-hour urinary lactulose excretion in Crohn's disease patients was significantly higher than in both celiac disease patients (0.42 vs 0.15%) and healthy controls (0.42 vs 0.07%). Urinary lactulose excretion was significantly higher in celiac disease patients than in healthy controls (0.15 vs 0.07%). Urinary mannitol excretion in Crohn's disease patients was the same as healthy controls (21 vs 21%) and these values were significantly higher than in celiac disease patients (10.9%). The lactulose/mannitol ratio was significantly higher in Crohn's disease patients in comparison to celiac disease patients (0.021 vs 0.013) and healthy controls (0.021 vs 0.003) and this ratio was also significantly higher in celiac disease patients compared to healthy controls (0.013 vs 0.003). In spite of treatment, differences in sugar permeability were observed in both disease groups. These differences in the behavior of the sugar probes probably reflect different mechanisms for the alterations of intestinal permeability.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200010Intestinal permeabilityCeliac diseaseCrohn's diseaseMannitolLactulose |
| spellingShingle | E.G. Vilela H.O.G. Torres M.L.A. Ferrari A.S. Lima A.S. Cunha Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects Brazilian Journal of Medical and Biological Research Intestinal permeability Celiac disease Crohn's disease Mannitol Lactulose |
| title | Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects |
| title_full | Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects |
| title_fullStr | Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects |
| title_full_unstemmed | Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects |
| title_short | Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects |
| title_sort | gut permeability to lactulose and mannitol differs in treated crohn s disease and celiac disease patients and healthy subjects |
| topic | Intestinal permeability Celiac disease Crohn's disease Mannitol Lactulose |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200010 |
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