Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies
Intestinal ischemia-reperfusion injury (IRI) is a potentially severe clinical syndrome after major surgical procedures. In addition to causing intestinal mucosa injury, intestinal IRI further damages distant organs, causing the severity of the condition in patients. So far, effective therapy for int...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1367170/full |
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| author | Zhan Huang Zhan Huang Zhan Huang Yiping Bai Yiping Bai Ying Chen Ying Chen Ye Chen Ye Chen Yuan Jiang Jun Zhou Jun Zhou |
| author_facet | Zhan Huang Zhan Huang Zhan Huang Yiping Bai Yiping Bai Ying Chen Ying Chen Ye Chen Ye Chen Yuan Jiang Jun Zhou Jun Zhou |
| author_sort | Zhan Huang |
| collection | DOAJ |
| description | Intestinal ischemia-reperfusion injury (IRI) is a potentially severe clinical syndrome after major surgical procedures. In addition to causing intestinal mucosa injury, intestinal IRI further damages distant organs, causing the severity of the condition in patients. So far, effective therapy for intestinal IRI is still absent, and the survival rate of the patients is low. Previous experimental studies have shown that some anesthetics can alleviate intestinal IRI and protect organs while exerting their pharmacological effects, indicating that reasonable perioperative anesthesia management may provide potential benefits for patients to avoid intestinal IRI. These meaningful findings drive scholars to investigate the mechanism of anesthetics in treating intestinal IRI in-depth to discuss the possible new clinical uses. In the present mini-review, we will introduce the protective effects of different anesthetics in intestinal IRI to help us enrich our knowledge in this area. |
| first_indexed | 2024-03-07T23:38:15Z |
| format | Article |
| id | doaj.art-552c73e42b8348508a9329b770336bff |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-07T23:38:15Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-552c73e42b8348508a9329b770336bff2024-02-20T04:24:31ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-02-011510.3389/fphar.2024.13671701367170Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studiesZhan Huang0Zhan Huang1Zhan Huang2Yiping Bai3Yiping Bai4Ying Chen5Ying Chen6Ye Chen7Ye Chen8Yuan Jiang9Jun Zhou10Jun Zhou11Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaAnesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, ChinaDepartment of Anesthesiology, Dazhou Integrated TCM & Western Medicine Hospital, Dazhou Second People’s Hospital, Dazhou, ChinaDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaAnesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, ChinaDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaAnesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, ChinaAnesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, ChinaDepartment of Traditional Chinese Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaClinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, ChinaDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaAnesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, ChinaIntestinal ischemia-reperfusion injury (IRI) is a potentially severe clinical syndrome after major surgical procedures. In addition to causing intestinal mucosa injury, intestinal IRI further damages distant organs, causing the severity of the condition in patients. So far, effective therapy for intestinal IRI is still absent, and the survival rate of the patients is low. Previous experimental studies have shown that some anesthetics can alleviate intestinal IRI and protect organs while exerting their pharmacological effects, indicating that reasonable perioperative anesthesia management may provide potential benefits for patients to avoid intestinal IRI. These meaningful findings drive scholars to investigate the mechanism of anesthetics in treating intestinal IRI in-depth to discuss the possible new clinical uses. In the present mini-review, we will introduce the protective effects of different anesthetics in intestinal IRI to help us enrich our knowledge in this area.https://www.frontiersin.org/articles/10.3389/fphar.2024.1367170/fullischemia-reperfusion injuryanesthetic managementgas anestheticsintravenous anestheticsanalgesics |
| spellingShingle | Zhan Huang Zhan Huang Zhan Huang Yiping Bai Yiping Bai Ying Chen Ying Chen Ye Chen Ye Chen Yuan Jiang Jun Zhou Jun Zhou Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies Frontiers in Pharmacology ischemia-reperfusion injury anesthetic management gas anesthetics intravenous anesthetics analgesics |
| title | Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies |
| title_full | Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies |
| title_fullStr | Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies |
| title_full_unstemmed | Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies |
| title_short | Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies |
| title_sort | attenuation of intestinal ischemia reperfusion injury by anesthetics a potentially protective effect of anesthetic management in experimental studies |
| topic | ischemia-reperfusion injury anesthetic management gas anesthetics intravenous anesthetics analgesics |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1367170/full |
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