Carboxypeptidase A4 negatively regulates HGS-ETR1/2-induced pyroptosis by forming a positive feedback loop with the AKT signalling pathway

Carboxypeptidase A4 negatively regulates HGS-ETR1/2-induced pyroptosis by forming a positive feedback loop with the AKT signalling pathway

Abstract Pyroptosis, a mode of inflammatory cell death, has recently gained significant attention. However, the underlying mechanism remains poorly understood. HGS-ETR1/2 is a humanized monoclonal antibody that can bind to DR4/5 on the cell membrane and induce cell apoptosis by activating the death...

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Bibliographic Details
Main Authors: Luoling Wang, Rilin Deng, Shuishun Chen, Renyun Tian, Mengmeng Guo, Zihao Chen, Yingdan Zhang, Huiyi Li, Qian Liu, Songqing Tang, Haizhen Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06327-5

Internet

https://doi.org/10.1038/s41419-023-06327-5

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