Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis

Abstract Angucyclines are type II polyketide natural products, often characterized by unusual structural rearrangements through B- or C-ring cleavage of their tetracyclic backbone. While the enzymes involved in B-ring cleavage have been extensively studied, little is known of the enzymes leading to...

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Bibliographic Details
Main Authors: Somayah S. Elsayed, Helga U. van der Heul, Xiansha Xiao, Aleksi Nuutila, Laura R. Baars, Changsheng Wu, Mikko Metsä-Ketelä, Gilles P. van Wezel
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-023-01059-1

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