Homology Models of Melatonin Receptors: Challenges and Recent Advances

Homology Models of Melatonin Receptors: Challenges and Recent Advances

Melatonin exerts many of its actions through the activation of two G protein-coupled receptors (GPCRs), named MT1 and MT2. So far, a number of different MT1 and MT2 receptor homology models, built either from the prototypic structure of rhodopsin or from recently solved X-ray structures of druggable...

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Bibliographic Details
Main Authors: Silvia Rivara, Gilberto Spadoni, Annalida Bedini, Alessio Lodola, Daniele Pala
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:International Journal of Molecular Sciences
Subjects:
melatonin receptors
MT1
MT2
homology modeling
structure-activity relationships
docking
molecular dynamics simulations
Online Access:http://www.mdpi.com/1422-0067/14/4/8093

Internet

http://www.mdpi.com/1422-0067/14/4/8093

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