Combined laser technology in diabetic macular edema treatment. A pilot study
Purpose. To assess preliminary clinical outcomes of combined laser treatment technology in patients with diabetic macular edema (DME).Material and methods. Six eyes of five patients with clinically significant diabetic macular edema were enrolled. The combined laser technology used a yellow waveleng...
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| Format: | Article |
| Language: | Russian |
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Publishing house "Ophthalmology"
2016-05-01
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| Series: | Офтальмохирургия |
| Subjects: | |
| Online Access: | https://www.ophthalmosurgery.ru/jour/article/view/228 |
| _version_ | 1797946769783390208 |
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| author | A. V. Doga G. F. Kachalina E. K. Pedanova D. A. Buryakov |
| author_facet | A. V. Doga G. F. Kachalina E. K. Pedanova D. A. Buryakov |
| author_sort | A. V. Doga |
| collection | DOAJ |
| description | Purpose. To assess preliminary clinical outcomes of combined laser treatment technology in patients with diabetic macular edema (DME).Material and methods. Six eyes of five patients with clinically significant diabetic macular edema were enrolled. The combined laser technology used a yellow wavelength (577nm) and included a combination of modified ETDRS focal/grid photocoagulation (mETDRS) and subthreshold micropulse yellow laser photocoagulation (SMYLP). The SMYLP was performed simultaneously with the mETDRS at the initial treatment and alone at the 1-month follow-up with laser settings adjusted individually in each case. All patients underwent the standard examination complemented with modern diagnostic techniques such as spectral-domain optical coherence tomography (OCT), fluorescein angiography, autofluorescence (AF), computer microperimetry (MP) at the baseline, 1- and 3-month follow-up.Results. The mean central retinal thickness decreased from the preoperative 393.5±116.9µm to 339.0±73.1µm at the 3-month follow-up. Resorption of macular edema was associated with the mean best corrected visual acuity (BCVA) improvement from 0.55±0.1 to 0.65±0.2. The mean central retinal sensitivity gradually increased from 11.2±2.4dB to 11.6±3.2dB after 3 months.Conclusion. The developed combined laser treatment technology in DME management has demonstrated promising clinical and functional outcomes resulting in the macular edema resorption and the central retinal sensitivity improvement in the short-term follow-up (3 months). One of the most prominent features of this technology is a foveal repetitive treatment possibility owing to a high selectivity of SMYLP to retinal pigment epithelium. Further clinical investigations are required to evaluate the efficacy and safety of the combined laser technology compared with the conventional laser treatment. |
| first_indexed | 2024-04-10T21:16:15Z |
| format | Article |
| id | doaj.art-552ee969b724456487fd7a13c9abf5b0 |
| institution | Directory Open Access Journal |
| issn | 0235-4160 2312-4970 |
| language | Russian |
| last_indexed | 2024-04-10T21:16:15Z |
| publishDate | 2016-05-01 |
| publisher | Publishing house "Ophthalmology" |
| record_format | Article |
| series | Офтальмохирургия |
| spelling | doaj.art-552ee969b724456487fd7a13c9abf5b02023-01-20T12:34:47ZrusPublishing house "Ophthalmology"Офтальмохирургия0235-41602312-49702016-05-0101394410.25276/0235-4160-2016-1-39-44217Combined laser technology in diabetic macular edema treatment. A pilot studyA. V. Doga0G. F. Kachalina1E. K. Pedanova2D. A. Buryakov3The S. Fyodorov Eye Microsurgery Federal State InstitutionThe S. Fyodorov Eye Microsurgery Federal State InstitutionThe S. Fyodorov Eye Microsurgery Federal State InstitutionThe S. Fyodorov Eye Microsurgery Federal State InstitutionPurpose. To assess preliminary clinical outcomes of combined laser treatment technology in patients with diabetic macular edema (DME).Material and methods. Six eyes of five patients with clinically significant diabetic macular edema were enrolled. The combined laser technology used a yellow wavelength (577nm) and included a combination of modified ETDRS focal/grid photocoagulation (mETDRS) and subthreshold micropulse yellow laser photocoagulation (SMYLP). The SMYLP was performed simultaneously with the mETDRS at the initial treatment and alone at the 1-month follow-up with laser settings adjusted individually in each case. All patients underwent the standard examination complemented with modern diagnostic techniques such as spectral-domain optical coherence tomography (OCT), fluorescein angiography, autofluorescence (AF), computer microperimetry (MP) at the baseline, 1- and 3-month follow-up.Results. The mean central retinal thickness decreased from the preoperative 393.5±116.9µm to 339.0±73.1µm at the 3-month follow-up. Resorption of macular edema was associated with the mean best corrected visual acuity (BCVA) improvement from 0.55±0.1 to 0.65±0.2. The mean central retinal sensitivity gradually increased from 11.2±2.4dB to 11.6±3.2dB after 3 months.Conclusion. The developed combined laser treatment technology in DME management has demonstrated promising clinical and functional outcomes resulting in the macular edema resorption and the central retinal sensitivity improvement in the short-term follow-up (3 months). One of the most prominent features of this technology is a foveal repetitive treatment possibility owing to a high selectivity of SMYLP to retinal pigment epithelium. Further clinical investigations are required to evaluate the efficacy and safety of the combined laser technology compared with the conventional laser treatment.https://www.ophthalmosurgery.ru/jour/article/view/228combined laser technologysubthreshold micropulse yellow laser photocoagulationretinal pigment epitheliumlaser photocoagulation of retinaoptical coherence tomographyautofluorescencecomputer microperimetry |
| spellingShingle | A. V. Doga G. F. Kachalina E. K. Pedanova D. A. Buryakov Combined laser technology in diabetic macular edema treatment. A pilot study Офтальмохирургия combined laser technology subthreshold micropulse yellow laser photocoagulation retinal pigment epithelium laser photocoagulation of retina optical coherence tomography autofluorescence computer microperimetry |
| title | Combined laser technology in diabetic macular edema treatment. A pilot study |
| title_full | Combined laser technology in diabetic macular edema treatment. A pilot study |
| title_fullStr | Combined laser technology in diabetic macular edema treatment. A pilot study |
| title_full_unstemmed | Combined laser technology in diabetic macular edema treatment. A pilot study |
| title_short | Combined laser technology in diabetic macular edema treatment. A pilot study |
| title_sort | combined laser technology in diabetic macular edema treatment a pilot study |
| topic | combined laser technology subthreshold micropulse yellow laser photocoagulation retinal pigment epithelium laser photocoagulation of retina optical coherence tomography autofluorescence computer microperimetry |
| url | https://www.ophthalmosurgery.ru/jour/article/view/228 |
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