TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagC<sup>S75Y</sup> Cardiomyopathy

TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagC<sup>S75Y</sup> Cardiomyopathy

A de novo missense variant in Rag GTPase protein C (RagC<sup>S75Y</sup>) was recently identified in a syndromic dilated cardiomyopathy (DCM) patient. However, its pathogenicity and the related therapeutic strategy remain unclear. We generated a zebrafish Rragc<sup>S56Y</sup>...

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Bibliographic Details
Main Authors: Maengjo Kim, Linghui Lu, Alexey V. Dvornikov, Xiao Ma, Yonghe Ding, Ping Zhu, Timothy M. Olson, Xueying Lin, Xiaolei Xu
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
RagC<sup>S75Y</sup>
cardiomyopathy
Rags
mTOR
TFEB
Online Access:https://www.mdpi.com/1422-0067/22/11/5494

Internet

https://www.mdpi.com/1422-0067/22/11/5494

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