Impact of pediatric traumatic brain injury on hippocampal neurogenesis
Traumatic brain injury (TBI) is a major cause of mortality and morbidity in the pediatric population. With advances in medical care, the mortality rate of pediatric TBI has declined. However, more children and adolescents are living with TBI-related cognitive and emotional impairments, which negativ...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=5;spage=926;epage=933;aulast=Rizk |
| _version_ | 1818451327139708928 |
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| author | Mariam Rizk Justin Vu Zhi Zhang |
| author_facet | Mariam Rizk Justin Vu Zhi Zhang |
| author_sort | Mariam Rizk |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) is a major cause of mortality and morbidity in the pediatric population. With advances in medical care, the mortality rate of pediatric TBI has declined. However, more children and adolescents are living with TBI-related cognitive and emotional impairments, which negatively affects the quality of their life. Adult hippocampal neurogenesis plays an important role in cognition and mood regulation. Alterations in adult hippocampal neurogenesis are associated with a variety of neurological and neurodegenerative diseases, including TBI. Promoting endogenous hippocampal neurogenesis after TBI merits significant attention. However, TBI affects the function of neural stem/progenitor cells in the dentate gyrus of hippocampus, which results in aberrant migration and impaired dendrite development of adult-born neurons. Therefore, a better understanding of adult hippocampal neurogenesis after TBI can facilitate a more successful neuro-restoration of damage in immature brains. Secondary injuries, such as neuroinflammation and oxidative stress, exert a significant impact on hippocampal neurogenesis. Currently, a variety of therapeutic approaches have been proposed for ameliorating secondary TBI injuries. In this review, we discuss the uniqueness of pediatric TBI, adult hippocampal neurogenesis after pediatric TBI, and current efforts that promote neuroprotection to the developing brains, which can be leveraged to facilitate neuroregeneration. |
| first_indexed | 2024-12-14T21:05:26Z |
| format | Article |
| id | doaj.art-552fe19dc2874a819e7d9df3952da0d1 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-14T21:05:26Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-552fe19dc2874a819e7d9df3952da0d12022-12-21T22:47:28ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742021-01-0116592693310.4103/1673-5374.297057Impact of pediatric traumatic brain injury on hippocampal neurogenesisMariam RizkJustin VuZhi ZhangTraumatic brain injury (TBI) is a major cause of mortality and morbidity in the pediatric population. With advances in medical care, the mortality rate of pediatric TBI has declined. However, more children and adolescents are living with TBI-related cognitive and emotional impairments, which negatively affects the quality of their life. Adult hippocampal neurogenesis plays an important role in cognition and mood regulation. Alterations in adult hippocampal neurogenesis are associated with a variety of neurological and neurodegenerative diseases, including TBI. Promoting endogenous hippocampal neurogenesis after TBI merits significant attention. However, TBI affects the function of neural stem/progenitor cells in the dentate gyrus of hippocampus, which results in aberrant migration and impaired dendrite development of adult-born neurons. Therefore, a better understanding of adult hippocampal neurogenesis after TBI can facilitate a more successful neuro-restoration of damage in immature brains. Secondary injuries, such as neuroinflammation and oxidative stress, exert a significant impact on hippocampal neurogenesis. Currently, a variety of therapeutic approaches have been proposed for ameliorating secondary TBI injuries. In this review, we discuss the uniqueness of pediatric TBI, adult hippocampal neurogenesis after pediatric TBI, and current efforts that promote neuroprotection to the developing brains, which can be leveraged to facilitate neuroregeneration.http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=5;spage=926;epage=933;aulast=Rizkadult hippocampal neurogenesis; astrocytes; development; microglia; neuroinflammation; neuroregeneration; oxidative stress; pediatric traumatic brain injury; plasticity; stem cell |
| spellingShingle | Mariam Rizk Justin Vu Zhi Zhang Impact of pediatric traumatic brain injury on hippocampal neurogenesis Neural Regeneration Research adult hippocampal neurogenesis; astrocytes; development; microglia; neuroinflammation; neuroregeneration; oxidative stress; pediatric traumatic brain injury; plasticity; stem cell |
| title | Impact of pediatric traumatic brain injury on hippocampal neurogenesis |
| title_full | Impact of pediatric traumatic brain injury on hippocampal neurogenesis |
| title_fullStr | Impact of pediatric traumatic brain injury on hippocampal neurogenesis |
| title_full_unstemmed | Impact of pediatric traumatic brain injury on hippocampal neurogenesis |
| title_short | Impact of pediatric traumatic brain injury on hippocampal neurogenesis |
| title_sort | impact of pediatric traumatic brain injury on hippocampal neurogenesis |
| topic | adult hippocampal neurogenesis; astrocytes; development; microglia; neuroinflammation; neuroregeneration; oxidative stress; pediatric traumatic brain injury; plasticity; stem cell |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=5;spage=926;epage=933;aulast=Rizk |
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