NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression
Abstract Gliomas are highly invasive and chemoresistant cancers, making them challenging to treat. Chronic inflammation is a key driver of glioma progression as it promotes aberrant activation of inflammatory pathways such as NF-κB signalling, which drives cancer cell invasion and angiogenesis. NF-κ...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04821-2 |
| _version_ | 1797840850815811584 |
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| author | Nicholas Sim Yinghui Li |
| author_facet | Nicholas Sim Yinghui Li |
| author_sort | Nicholas Sim |
| collection | DOAJ |
| description | Abstract Gliomas are highly invasive and chemoresistant cancers, making them challenging to treat. Chronic inflammation is a key driver of glioma progression as it promotes aberrant activation of inflammatory pathways such as NF-κB signalling, which drives cancer cell invasion and angiogenesis. NF-κB factors typically dimerise with its own family members, but emerging evidence of their promiscuous interactions with other oncogenic factors has been reported to promote transcription of new target genes and function. Here, we show that non-canonical NF-κB activation directly regulates p52 at the ETS1 promoter, activating its expression. This impacts the genomic and transcriptional landscape of ETS1 in a glioma-specific manner. We further show that enhanced non-canonical NF-κB signalling promotes the co-localisation of p52 and ETS1, resulting in transcriptional activation of non-κB and/or non-ETS glioma-promoting genes. We conclude that p52-induced ETS1 overexpression in glioma cells remodels the genome-wide regulatory network of p52 and ETS1 to transcriptionally drive cancer progression. |
| first_indexed | 2024-04-09T16:21:28Z |
| format | Article |
| id | doaj.art-5530b588ff594fc5a506d33d5f8aa8e1 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-09T16:21:28Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-5530b588ff594fc5a506d33d5f8aa8e12023-04-23T11:25:46ZengNature PortfolioCommunications Biology2399-36422023-04-016111010.1038/s42003-023-04821-2NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progressionNicholas Sim0Yinghui Li1School of Biological Sciences (SBS), Nanyang Technological University (NTU)School of Biological Sciences (SBS), Nanyang Technological University (NTU)Abstract Gliomas are highly invasive and chemoresistant cancers, making them challenging to treat. Chronic inflammation is a key driver of glioma progression as it promotes aberrant activation of inflammatory pathways such as NF-κB signalling, which drives cancer cell invasion and angiogenesis. NF-κB factors typically dimerise with its own family members, but emerging evidence of their promiscuous interactions with other oncogenic factors has been reported to promote transcription of new target genes and function. Here, we show that non-canonical NF-κB activation directly regulates p52 at the ETS1 promoter, activating its expression. This impacts the genomic and transcriptional landscape of ETS1 in a glioma-specific manner. We further show that enhanced non-canonical NF-κB signalling promotes the co-localisation of p52 and ETS1, resulting in transcriptional activation of non-κB and/or non-ETS glioma-promoting genes. We conclude that p52-induced ETS1 overexpression in glioma cells remodels the genome-wide regulatory network of p52 and ETS1 to transcriptionally drive cancer progression.https://doi.org/10.1038/s42003-023-04821-2 |
| spellingShingle | Nicholas Sim Yinghui Li NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression Communications Biology |
| title | NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression |
| title_full | NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression |
| title_fullStr | NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression |
| title_full_unstemmed | NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression |
| title_short | NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression |
| title_sort | nf κb p52 augments ets1 binding genome wide to promote glioma progression |
| url | https://doi.org/10.1038/s42003-023-04821-2 |
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