The Influence of Ethnicity on Warfarin Dosage Requirements in the Chilean Population
Background: Vitamin K antagonists are drugs that are widely prescribed around the world and their use has helped improve the prognosis of patients with thromboembolic disease. However, a high interindividual variability has been observed in dosage requirements to reach the desired anticoagulation ra...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-12-01
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| Series: | Current Therapeutic Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0011393X14000319 |
| _version_ | 1811312237701234688 |
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| author | Valeska Subiabre, MsCs Ivan Palomo, PhD Neftalí Guzmán, PhD Eduardo Retamales, MsCs Hugo Henríquez, MsCs Luis Gonzalez, MsCs |
| author_facet | Valeska Subiabre, MsCs Ivan Palomo, PhD Neftalí Guzmán, PhD Eduardo Retamales, MsCs Hugo Henríquez, MsCs Luis Gonzalez, MsCs |
| author_sort | Valeska Subiabre, MsCs |
| collection | DOAJ |
| description | Background: Vitamin K antagonists are drugs that are widely prescribed around the world and their use has helped improve the prognosis of patients with thromboembolic disease. However, a high interindividual variability has been observed in dosage requirements to reach the desired anticoagulation range that could be due to environmental and genetic factors. Studies suggest that ethnicity influences coumarin response, supporting the observed differences in dose requirements across various populations. Studies using mitochondrial DNA (mtDNA) markers have suggested that the Chilean population has a predominantly Amerindian genetic pool.
Objective: To evaluate the influence of ethnicity, defined by the presence of Amerindian mtDNA haplogroups, on the variability in therapeutic response to warfarin in the Chilean population.
Methods: A total of 191 patients treated with warfarin were included in this study. Analysis of the mitochondrial genome for detecting the presence of Amerindian mtDNA haplogroups was performed using polymerase chain reaction and polymerase chain reaction restriction fragment length polymorphism techniques. The evaluation of warfarin requirements according to each haplogroup was performed by ANOVA with a 95% CI and assuming statistical significance at P < 0.05.
Results: Based on the presence of an mtDNA haplogroup, 91% of the Chilean population had an Amerindian background. There were no significant differences in warfarin dosage requirements among the different Amerindian haplogroups (P = 0.083).
Conclusions: The presence of Amerindian mtDNA haplogroup does not influence warfarin dosage requirements in the Chilean population. |
| first_indexed | 2024-04-13T10:33:50Z |
| format | Article |
| id | doaj.art-55310e3e800642cfac0c32e3e763ab1c |
| institution | Directory Open Access Journal |
| issn | 0011-393X 1879-0313 |
| language | English |
| last_indexed | 2024-04-13T10:33:50Z |
| publishDate | 2015-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Therapeutic Research |
| spelling | doaj.art-55310e3e800642cfac0c32e3e763ab1c2022-12-22T02:50:07ZengElsevierCurrent Therapeutic Research0011-393X1879-03132015-12-0177C313410.1016/j.curtheres.2014.12.002The Influence of Ethnicity on Warfarin Dosage Requirements in the Chilean PopulationValeska Subiabre, MsCs0Ivan Palomo, PhD1Neftalí Guzmán, PhD2Eduardo Retamales, MsCs3Hugo Henríquez, MsCs4Luis Gonzalez, MsCs5The Clinical and Immunohematological Department, Faculty of Health Sciences, Universidad de Talca, Talca, ChileThe Clinical and Immunohematological Department, Faculty of Health Sciences, Universidad de Talca, Talca, ChileMolecular Diagnosis Laboratory, Faculty of Health Sciences, Universidad San Sebastián, Concepcion, ChileBiomedical Laboratory Department, The National Hematology Reference Laboratory, Chile’s Public Health Institute, Santiago, ChileEscuela de Tecnología Médica. Universidad Mayor, Santiago, ChileInternal Medicine Department, Universidad de La Frontera, Temuco, ChileBackground: Vitamin K antagonists are drugs that are widely prescribed around the world and their use has helped improve the prognosis of patients with thromboembolic disease. However, a high interindividual variability has been observed in dosage requirements to reach the desired anticoagulation range that could be due to environmental and genetic factors. Studies suggest that ethnicity influences coumarin response, supporting the observed differences in dose requirements across various populations. Studies using mitochondrial DNA (mtDNA) markers have suggested that the Chilean population has a predominantly Amerindian genetic pool. Objective: To evaluate the influence of ethnicity, defined by the presence of Amerindian mtDNA haplogroups, on the variability in therapeutic response to warfarin in the Chilean population. Methods: A total of 191 patients treated with warfarin were included in this study. Analysis of the mitochondrial genome for detecting the presence of Amerindian mtDNA haplogroups was performed using polymerase chain reaction and polymerase chain reaction restriction fragment length polymorphism techniques. The evaluation of warfarin requirements according to each haplogroup was performed by ANOVA with a 95% CI and assuming statistical significance at P < 0.05. Results: Based on the presence of an mtDNA haplogroup, 91% of the Chilean population had an Amerindian background. There were no significant differences in warfarin dosage requirements among the different Amerindian haplogroups (P = 0.083). Conclusions: The presence of Amerindian mtDNA haplogroup does not influence warfarin dosage requirements in the Chilean population.http://www.sciencedirect.com/science/article/pii/S0011393X14000319anticoagulant therapymitochondrial DNApharmacogenomicswarfarin |
| spellingShingle | Valeska Subiabre, MsCs Ivan Palomo, PhD Neftalí Guzmán, PhD Eduardo Retamales, MsCs Hugo Henríquez, MsCs Luis Gonzalez, MsCs The Influence of Ethnicity on Warfarin Dosage Requirements in the Chilean Population Current Therapeutic Research anticoagulant therapy mitochondrial DNA pharmacogenomics warfarin |
| title | The Influence of Ethnicity on Warfarin Dosage Requirements in the Chilean Population |
| title_full | The Influence of Ethnicity on Warfarin Dosage Requirements in the Chilean Population |
| title_fullStr | The Influence of Ethnicity on Warfarin Dosage Requirements in the Chilean Population |
| title_full_unstemmed | The Influence of Ethnicity on Warfarin Dosage Requirements in the Chilean Population |
| title_short | The Influence of Ethnicity on Warfarin Dosage Requirements in the Chilean Population |
| title_sort | influence of ethnicity on warfarin dosage requirements in the chilean population |
| topic | anticoagulant therapy mitochondrial DNA pharmacogenomics warfarin |
| url | http://www.sciencedirect.com/science/article/pii/S0011393X14000319 |
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