Frailty Factors and Outcomes in Patients Undergoing Orthopedic Surgery: Protocol for a Systematic Review and Meta-analysis
BackgroundFrailty is an aggregate expression of susceptibility to adverse health outcomes because of age- and disease-related deficits that accumulate across multiple domains. Previous studies have found the presence of preoperative frailty is associated with an increased ris...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JMIR Publications
2022-04-01
|
| Series: | JMIR Research Protocols |
| Online Access: | https://www.researchprotocols.org/2022/4/e28338 |
| _version_ | 1797735124038582272 |
|---|---|
| author | Duanyang Wang Pengbin Yin Yi Li Ming Chen Xiang Cui Shi Cheng Yuan Lin Jinglong Yan Licheng Zhang Peifu Tang |
| author_facet | Duanyang Wang Pengbin Yin Yi Li Ming Chen Xiang Cui Shi Cheng Yuan Lin Jinglong Yan Licheng Zhang Peifu Tang |
| author_sort | Duanyang Wang |
| collection | DOAJ |
| description |
BackgroundFrailty is an aggregate expression of susceptibility to adverse health outcomes because of age- and disease-related deficits that accumulate across multiple domains. Previous studies have found the presence of preoperative frailty is associated with an increased risk of adverse outcomes. The number of older adults undergoing orthopedic surgery is rapidly increasing. However, there has been no evidence-based study on the relationship between frailty and outcomes in patients undergoing orthopedic surgery.
ObjectiveThe aims of this study are to investigate the association between frailty and outcomes in patients who underwent orthopedic surgery as well as patient factors associated with frailty.
MethodsThe methods to be used for this systematic review are reported according to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-analysis Protocols) 2015 checklist. An extensive search will be conducted in PubMed, Embase, the Cochrane Library, and other mainstream databases. Any study where patients undergoing orthopedic surgery were assessed using a defined or validated measure of frailty and the association of frailty with patient factors and/or outcomes was reported will be included. A total of 2 researchers will independently screen articles for inclusion, with disagreements resolved by a third reviewer. We will perform a narrative synthesis of the factors associated with frailty, prevalence of frailty, effect of frailty on patient outcomes, and interventions for patients who are frail. A meta-analysis focusing on individual factors associated with frailty and the effect of frailty on patient outcomes will be performed, if applicable. The risk of bias will be evaluated. A subgroup analysis and sensitivity analysis will be performed.
ResultsLiterature searches were conducted in September 2021 and the review is anticipated to be completed by the end of July 2022.
ConclusionsThis systematic review and meta-analysis will provide an overview of frailty and investigate the relationship between frailty and patient outcomes as well as the relationship between patient factors and frailty in patients undergoing orthopedic surgery. This study could potentially increase patients’ awareness of the outcomes associated with frailty, compel clinical specialties to further acknowledge the concept of frailty, and enhance the development of assessment instruments and tools for frailty.
Trial RegistrationPROSPERO CRD42020181846; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=181846
International Registered Report Identifier (IRRID)DERR1-10.2196/28338 |
| first_indexed | 2024-03-12T12:54:29Z |
| format | Article |
| id | doaj.art-5532d6f59b3d4da48083895e1ec36ae3 |
| institution | Directory Open Access Journal |
| issn | 1929-0748 |
| language | English |
| last_indexed | 2024-03-12T12:54:29Z |
| publishDate | 2022-04-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Research Protocols |
| spelling | doaj.art-5532d6f59b3d4da48083895e1ec36ae32023-08-28T21:25:10ZengJMIR PublicationsJMIR Research Protocols1929-07482022-04-01114e2833810.2196/28338Frailty Factors and Outcomes in Patients Undergoing Orthopedic Surgery: Protocol for a Systematic Review and Meta-analysisDuanyang Wanghttps://orcid.org/0000-0002-1477-2103Pengbin Yinhttps://orcid.org/0000-0002-5391-4477Yi Lihttps://orcid.org/0000-0001-6163-7716Ming Chenhttps://orcid.org/0000-0002-6629-211XXiang Cuihttps://orcid.org/0000-0002-6704-1611Shi Chenghttps://orcid.org/0000-0002-6215-7842Yuan Linhttps://orcid.org/0000-0003-4441-6182Jinglong Yanhttps://orcid.org/0000-0003-0622-6249Licheng Zhanghttps://orcid.org/0000-0002-6782-1749Peifu Tanghttps://orcid.org/0000-0003-4279-1704 BackgroundFrailty is an aggregate expression of susceptibility to adverse health outcomes because of age- and disease-related deficits that accumulate across multiple domains. Previous studies have found the presence of preoperative frailty is associated with an increased risk of adverse outcomes. The number of older adults undergoing orthopedic surgery is rapidly increasing. However, there has been no evidence-based study on the relationship between frailty and outcomes in patients undergoing orthopedic surgery. ObjectiveThe aims of this study are to investigate the association between frailty and outcomes in patients who underwent orthopedic surgery as well as patient factors associated with frailty. MethodsThe methods to be used for this systematic review are reported according to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-analysis Protocols) 2015 checklist. An extensive search will be conducted in PubMed, Embase, the Cochrane Library, and other mainstream databases. Any study where patients undergoing orthopedic surgery were assessed using a defined or validated measure of frailty and the association of frailty with patient factors and/or outcomes was reported will be included. A total of 2 researchers will independently screen articles for inclusion, with disagreements resolved by a third reviewer. We will perform a narrative synthesis of the factors associated with frailty, prevalence of frailty, effect of frailty on patient outcomes, and interventions for patients who are frail. A meta-analysis focusing on individual factors associated with frailty and the effect of frailty on patient outcomes will be performed, if applicable. The risk of bias will be evaluated. A subgroup analysis and sensitivity analysis will be performed. ResultsLiterature searches were conducted in September 2021 and the review is anticipated to be completed by the end of July 2022. ConclusionsThis systematic review and meta-analysis will provide an overview of frailty and investigate the relationship between frailty and patient outcomes as well as the relationship between patient factors and frailty in patients undergoing orthopedic surgery. This study could potentially increase patients’ awareness of the outcomes associated with frailty, compel clinical specialties to further acknowledge the concept of frailty, and enhance the development of assessment instruments and tools for frailty. Trial RegistrationPROSPERO CRD42020181846; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=181846 International Registered Report Identifier (IRRID)DERR1-10.2196/28338https://www.researchprotocols.org/2022/4/e28338 |
| spellingShingle | Duanyang Wang Pengbin Yin Yi Li Ming Chen Xiang Cui Shi Cheng Yuan Lin Jinglong Yan Licheng Zhang Peifu Tang Frailty Factors and Outcomes in Patients Undergoing Orthopedic Surgery: Protocol for a Systematic Review and Meta-analysis JMIR Research Protocols |
| title | Frailty Factors and Outcomes in Patients Undergoing Orthopedic Surgery: Protocol for a Systematic Review and Meta-analysis |
| title_full | Frailty Factors and Outcomes in Patients Undergoing Orthopedic Surgery: Protocol for a Systematic Review and Meta-analysis |
| title_fullStr | Frailty Factors and Outcomes in Patients Undergoing Orthopedic Surgery: Protocol for a Systematic Review and Meta-analysis |
| title_full_unstemmed | Frailty Factors and Outcomes in Patients Undergoing Orthopedic Surgery: Protocol for a Systematic Review and Meta-analysis |
| title_short | Frailty Factors and Outcomes in Patients Undergoing Orthopedic Surgery: Protocol for a Systematic Review and Meta-analysis |
| title_sort | frailty factors and outcomes in patients undergoing orthopedic surgery protocol for a systematic review and meta analysis |
| url | https://www.researchprotocols.org/2022/4/e28338 |
| work_keys_str_mv | AT duanyangwang frailtyfactorsandoutcomesinpatientsundergoingorthopedicsurgeryprotocolforasystematicreviewandmetaanalysis AT pengbinyin frailtyfactorsandoutcomesinpatientsundergoingorthopedicsurgeryprotocolforasystematicreviewandmetaanalysis AT yili frailtyfactorsandoutcomesinpatientsundergoingorthopedicsurgeryprotocolforasystematicreviewandmetaanalysis AT mingchen frailtyfactorsandoutcomesinpatientsundergoingorthopedicsurgeryprotocolforasystematicreviewandmetaanalysis AT xiangcui frailtyfactorsandoutcomesinpatientsundergoingorthopedicsurgeryprotocolforasystematicreviewandmetaanalysis AT shicheng frailtyfactorsandoutcomesinpatientsundergoingorthopedicsurgeryprotocolforasystematicreviewandmetaanalysis AT yuanlin frailtyfactorsandoutcomesinpatientsundergoingorthopedicsurgeryprotocolforasystematicreviewandmetaanalysis AT jinglongyan frailtyfactorsandoutcomesinpatientsundergoingorthopedicsurgeryprotocolforasystematicreviewandmetaanalysis AT lichengzhang frailtyfactorsandoutcomesinpatientsundergoingorthopedicsurgeryprotocolforasystematicreviewandmetaanalysis AT peifutang frailtyfactorsandoutcomesinpatientsundergoingorthopedicsurgeryprotocolforasystematicreviewandmetaanalysis |