Green synthesis of carbon quantum dots from plant turmeric holds promise as novel photosensitizer for in vitro photodynamic antimicrobial activity
Research has shown that carbon quantum dots (CQDs) are active as novel carbon nanomaterials in photodynamic therapy due to their excellent photophysical properties. However, previously expensive precursors and time-consuming production processes, as well as complex doping/functionalization forms hav...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Journal of Materials Research and Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785422017975 |
| _version_ | 1828054114846638080 |
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| author | Hongjun Yan Peiyuan Li Fangzhou Wen Qiuting Xu Qing Guo Wei Su |
| author_facet | Hongjun Yan Peiyuan Li Fangzhou Wen Qiuting Xu Qing Guo Wei Su |
| author_sort | Hongjun Yan |
| collection | DOAJ |
| description | Research has shown that carbon quantum dots (CQDs) are active as novel carbon nanomaterials in photodynamic therapy due to their excellent photophysical properties. However, previously expensive precursors and time-consuming production processes, as well as complex doping/functionalization forms have limited their economic design and use. In this study, we prepared ST-JHCQDs by a simple and green method using natural plant turmeric as the carbon source, and characterized ST-JHCQDs by physical and optical means. In vitro antibacterial results showed that the antibacterial effects of ST-JHCQDs against E. coli and S. aureus under the irradiation of blue light depended on carbonization degrees, concentration and light duration. Biomolecule leakage and confocal laser scanning microscope analysis showed that ST-JHCQDs were effective in producing reactive oxygen species (ROS) under blue light irradiation, which resulted in disturbance of cell membrane integrity and leakage of intracellular macromolecules in both bacteria. Meanwhile, scanning electron microscopy images showed cell membrane wrinkling and fragmentation, which was consistent with ROS damage, demonstrating the effectiveness of ST-JHCQDs as photosensitizers in vitro photodynamic antimicrobial activity. These experiments show that CQDs prepared from turmeric was a new natural photosensitizer material with great antibacterial potential. |
| first_indexed | 2024-04-10T20:17:42Z |
| format | Article |
| id | doaj.art-55333bda754343fe9ea018e381da26e8 |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-04-10T20:17:42Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-55333bda754343fe9ea018e381da26e82023-01-26T04:45:28ZengElsevierJournal of Materials Research and Technology2238-78542023-01-01221734Green synthesis of carbon quantum dots from plant turmeric holds promise as novel photosensitizer for in vitro photodynamic antimicrobial activityHongjun Yan0Peiyuan Li1Fangzhou Wen2Qiuting Xu3Qing Guo4Wei Su5College of Pharmacy, Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning, ChinaCollege of Pharmacy, Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning, China; Corresponding author.College of Pharmacy, Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning, ChinaCollege of Pharmacy, Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning, ChinaCollege of Pharmacy, Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning, ChinaGuangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning 530001, PR China; Corresponding author.Research has shown that carbon quantum dots (CQDs) are active as novel carbon nanomaterials in photodynamic therapy due to their excellent photophysical properties. However, previously expensive precursors and time-consuming production processes, as well as complex doping/functionalization forms have limited their economic design and use. In this study, we prepared ST-JHCQDs by a simple and green method using natural plant turmeric as the carbon source, and characterized ST-JHCQDs by physical and optical means. In vitro antibacterial results showed that the antibacterial effects of ST-JHCQDs against E. coli and S. aureus under the irradiation of blue light depended on carbonization degrees, concentration and light duration. Biomolecule leakage and confocal laser scanning microscope analysis showed that ST-JHCQDs were effective in producing reactive oxygen species (ROS) under blue light irradiation, which resulted in disturbance of cell membrane integrity and leakage of intracellular macromolecules in both bacteria. Meanwhile, scanning electron microscopy images showed cell membrane wrinkling and fragmentation, which was consistent with ROS damage, demonstrating the effectiveness of ST-JHCQDs as photosensitizers in vitro photodynamic antimicrobial activity. These experiments show that CQDs prepared from turmeric was a new natural photosensitizer material with great antibacterial potential.http://www.sciencedirect.com/science/article/pii/S2238785422017975Carbon quantum dotsPhotodynamicAntibacterialTurmericReactive oxygen speciesPhotosensitizers |
| spellingShingle | Hongjun Yan Peiyuan Li Fangzhou Wen Qiuting Xu Qing Guo Wei Su Green synthesis of carbon quantum dots from plant turmeric holds promise as novel photosensitizer for in vitro photodynamic antimicrobial activity Journal of Materials Research and Technology Carbon quantum dots Photodynamic Antibacterial Turmeric Reactive oxygen species Photosensitizers |
| title | Green synthesis of carbon quantum dots from plant turmeric holds promise as novel photosensitizer for in vitro photodynamic antimicrobial activity |
| title_full | Green synthesis of carbon quantum dots from plant turmeric holds promise as novel photosensitizer for in vitro photodynamic antimicrobial activity |
| title_fullStr | Green synthesis of carbon quantum dots from plant turmeric holds promise as novel photosensitizer for in vitro photodynamic antimicrobial activity |
| title_full_unstemmed | Green synthesis of carbon quantum dots from plant turmeric holds promise as novel photosensitizer for in vitro photodynamic antimicrobial activity |
| title_short | Green synthesis of carbon quantum dots from plant turmeric holds promise as novel photosensitizer for in vitro photodynamic antimicrobial activity |
| title_sort | green synthesis of carbon quantum dots from plant turmeric holds promise as novel photosensitizer for in vitro photodynamic antimicrobial activity |
| topic | Carbon quantum dots Photodynamic Antibacterial Turmeric Reactive oxygen species Photosensitizers |
| url | http://www.sciencedirect.com/science/article/pii/S2238785422017975 |
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