Cherubism: Clinicoradiographic Features and Treatment
Objectives: Cherubism is a congenital childhood disease of autosomal dominant inheritance. This disease is characterized by painless bilateral enlargement of the jaws, in which bone is replaced with fibrous tissue. The condition has sui generis clinical, radiographic and histological features, of wh...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Stilus Optimus
2010-04-01
|
| Series: | eJournal of Oral Maxillofacial Research |
| Subjects: | |
| Online Access: | http://www.ejomr.org/JOMR/archives/2010/2/e2/e2ht.pdf |
| _version_ | 1818881981788717056 |
|---|---|
| author | Luiz Antonio Guimarães Cabral Janete Dias Almeida Gabriela de Morais Gouvêa Lima |
| author_facet | Luiz Antonio Guimarães Cabral Janete Dias Almeida Gabriela de Morais Gouvêa Lima |
| author_sort | Luiz Antonio Guimarães Cabral |
| collection | DOAJ |
| description | Objectives: Cherubism is a congenital childhood disease of autosomal dominant inheritance. This disease is characterized by painless bilateral enlargement of the jaws, in which bone is replaced with fibrous tissue. The condition has sui generis clinical, radiographic and histological features, of which the clinician should be aware for a better differential diagnosis in the presence of a fibro-osseous lesion affecting the bones of the maxillomandibular complex. The purpose of present paper was to review the literature and to report the most important aspects of cherubism in order to facilitate the study of this disease.Material and Methods: Literature was reviewed about cherubism, emphasizing the relevant clinicoradiographic features and treatment. Literature was selected through a search of PubMed and Scielo electronic databases. The keywords used for search were adolescent, cherubism, cherubism/physiopathology, cherubism/treatment, cherubism/radiography. A manual search of the reference lists of the identified articles and the authors’ article files and recent reviews was conducted to identify additional publications. Those studies that described new features about cherubism were included in this review.Results: In total 44 literature sources were obtained and reviewed. Studies that described new features about cherubism physiopathology, diagnostics and treatment were reviewed.Conclusions: Despite the exceptions, cherubism is a clinically well-characterized disease. In cases of a suspicion of cherubism, radiographic examination is essential since the clinical presentation, the location and distribution of the lesions may define the diagnosis. Histopathological examination is complementary. Nowadays, genetic tests should be used for final diagnosis of cherubism. |
| first_indexed | 2024-12-19T15:10:30Z |
| format | Article |
| id | doaj.art-55351e069b5c4e19af174076b08f9640 |
| institution | Directory Open Access Journal |
| issn | 2029-283X |
| language | English |
| last_indexed | 2024-12-19T15:10:30Z |
| publishDate | 2010-04-01 |
| publisher | Stilus Optimus |
| record_format | Article |
| series | eJournal of Oral Maxillofacial Research |
| spelling | doaj.art-55351e069b5c4e19af174076b08f96402022-12-21T20:16:20ZengStilus OptimuseJournal of Oral Maxillofacial Research2029-283X2010-04-0112e2Cherubism: Clinicoradiographic Features and TreatmentLuiz Antonio Guimarães CabralJanete Dias AlmeidaGabriela de Morais Gouvêa LimaObjectives: Cherubism is a congenital childhood disease of autosomal dominant inheritance. This disease is characterized by painless bilateral enlargement of the jaws, in which bone is replaced with fibrous tissue. The condition has sui generis clinical, radiographic and histological features, of which the clinician should be aware for a better differential diagnosis in the presence of a fibro-osseous lesion affecting the bones of the maxillomandibular complex. The purpose of present paper was to review the literature and to report the most important aspects of cherubism in order to facilitate the study of this disease.Material and Methods: Literature was reviewed about cherubism, emphasizing the relevant clinicoradiographic features and treatment. Literature was selected through a search of PubMed and Scielo electronic databases. The keywords used for search were adolescent, cherubism, cherubism/physiopathology, cherubism/treatment, cherubism/radiography. A manual search of the reference lists of the identified articles and the authors’ article files and recent reviews was conducted to identify additional publications. Those studies that described new features about cherubism were included in this review.Results: In total 44 literature sources were obtained and reviewed. Studies that described new features about cherubism physiopathology, diagnostics and treatment were reviewed.Conclusions: Despite the exceptions, cherubism is a clinically well-characterized disease. In cases of a suspicion of cherubism, radiographic examination is essential since the clinical presentation, the location and distribution of the lesions may define the diagnosis. Histopathological examination is complementary. Nowadays, genetic tests should be used for final diagnosis of cherubism.http://www.ejomr.org/JOMR/archives/2010/2/e2/e2ht.pdfadolescentjaw diseasescherubism |
| spellingShingle | Luiz Antonio Guimarães Cabral Janete Dias Almeida Gabriela de Morais Gouvêa Lima Cherubism: Clinicoradiographic Features and Treatment eJournal of Oral Maxillofacial Research adolescent jaw diseases cherubism |
| title | Cherubism: Clinicoradiographic Features and Treatment |
| title_full | Cherubism: Clinicoradiographic Features and Treatment |
| title_fullStr | Cherubism: Clinicoradiographic Features and Treatment |
| title_full_unstemmed | Cherubism: Clinicoradiographic Features and Treatment |
| title_short | Cherubism: Clinicoradiographic Features and Treatment |
| title_sort | cherubism clinicoradiographic features and treatment |
| topic | adolescent jaw diseases cherubism |
| url | http://www.ejomr.org/JOMR/archives/2010/2/e2/e2ht.pdf |
| work_keys_str_mv | AT luizantonioguimaraescabral cherubismclinicoradiographicfeaturesandtreatment AT janetediasalmeida cherubismclinicoradiographicfeaturesandtreatment AT gabrielademoraisgouvealima cherubismclinicoradiographicfeaturesandtreatment |