The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning, and memory. The LC-NE system is also implicated in multiple...

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Bibliographic Details
Main Authors: Lukas M Weber, Heena R Divecha, Matthew N Tran, Sang Ho Kwon, Abby Spangler, Kelsey D Montgomery, Madhavi Tippani, Rahul Bharadwaj, Joel E Kleinman, Stephanie C Page, Thomas M Hyde, Leonardo Collado-Torres, Kristen R Maynard, Keri Martinowich, Stephanie C Hicks
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
locus coeruleus
norepinephrine
spatially-resolved transcriptomics
single-nucleus RNA-sequencing
postmortem human tissue
Online Access:https://elifesciences.org/articles/84628

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