Leprosy reaction and immune reconstitution syndrome in AIDS

The authors report seven cases of borderline leprosy in AIDS patients whose presentation form was of a type I reaction diagnosed soon HAART introduction, which led to the discussion of the immunological aspects involved in the reaction to leprosy and the immune reconstitution syndrome. The patients...

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Bibliographic Details
Main Authors: Trope Beatriz Moritz, Lenzi Maria Elisa Ribeiro, Maceira Juan Piñeiro, Barroso Paulo Feijó, Oliveira Maria Leide W. de
Format: Article
Language:English
Published: Instituto Lauro de Souza Lima 2008-06-01
Series:Hansenologia Internationalis
Online Access:https://periodicos.saude.sp.gov.br/hansenologia/article/view/35176
Description
Summary:The authors report seven cases of borderline leprosy in AIDS patients whose presentation form was of a type I reaction diagnosed soon HAART introduction, which led to the discussion of the immunological aspects involved in the reaction to leprosy and the immune reconstitution syndrome. The patients were in frank AIDS-induced immune deterioration, which was the reason they met the criteria to initiate HAART treatment. It is likely that due to this fact, the amount of CD4 cells increased at the same time that a reduction of the viral load occurred, allowing the installation of a basically Th1 immunological profile. Therefore, the leprosy infection, which was dormant and unable to express itself was exteriorized in the form of a reverse reaction.
ISSN:1982-5161