Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men
Background: Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Japan Epidemiological Association
2018-04-01
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| Series: | Journal of Epidemiology |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jea/28/4/28_JE20160189/_pdf |
| _version_ | 1818993974671572992 |
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| author | Tae Sasakabe Kenji Wakai Sayo Kawai Asahi Hishida Mariko Naito Sadao Suzuki Yora Nindita Kokichi Arisawa Yoshikuni Kita Megumi Hara Nagato Kuriyama Akie Hirata Haruo Mikami Isao Oze Michiaki Kubo Hideo Tanaka Nobuyuki Hamajima |
| author_facet | Tae Sasakabe Kenji Wakai Sayo Kawai Asahi Hishida Mariko Naito Sadao Suzuki Yora Nindita Kokichi Arisawa Yoshikuni Kita Megumi Hara Nagato Kuriyama Akie Hirata Haruo Mikami Isao Oze Michiaki Kubo Hideo Tanaka Nobuyuki Hamajima |
| author_sort | Tae Sasakabe |
| collection | DOAJ |
| description | Background: Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated. Methods: We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study. Results: The ALDH2 Glu/Lys or Lys/Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g/day was −2.49 mg/dL (95% confidence interval [CI], −3.85 to −1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (−3.24 mg/dL, 95% CI, −5.03 to −1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His/His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu/Lys or Lys/Lys groups was replicated. Conclusions: The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men. |
| first_indexed | 2024-12-20T20:50:35Z |
| format | Article |
| id | doaj.art-5537ab4e289b43878b57594fee38f21e |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-12-20T20:50:35Z |
| publishDate | 2018-04-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-5537ab4e289b43878b57594fee38f21e2022-12-21T19:26:56ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922018-04-0128418519310.2188/jea.JE20160189Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese MenTae Sasakabe0Kenji Wakai1Sayo Kawai2Asahi Hishida3Mariko Naito4Sadao Suzuki5Yora Nindita6Kokichi Arisawa7Yoshikuni Kita8Megumi Hara9Nagato Kuriyama10Akie Hirata11Haruo Mikami12Isao Oze13Michiaki Kubo14Hideo Tanaka15Nobuyuki Hamajima16Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanDepartment of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, JapanFaculty of Nursing Science, Tsuruga Nursing University, Tsuruga, JapanDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga, JapanDepartment of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, JapanDepartment of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDivision of Cancer Registry, Prevention and Epidemiology, Chiba Cancer Center Research Institute, Chiba, JapanDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, JapanCenter for Integrative Medical Sciences, RIKEN, Yokohama, JapanDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, JapanDepartment of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, JapanBackground: Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated. Methods: We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study. Results: The ALDH2 Glu/Lys or Lys/Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g/day was −2.49 mg/dL (95% confidence interval [CI], −3.85 to −1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (−3.24 mg/dL, 95% CI, −5.03 to −1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His/His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu/Lys or Lys/Lys groups was replicated. Conclusions: The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men.https://www.jstage.jst.go.jp/article/jea/28/4/28_JE20160189/_pdfALDH2ADH1Balcohol intakelipid profile |
| spellingShingle | Tae Sasakabe Kenji Wakai Sayo Kawai Asahi Hishida Mariko Naito Sadao Suzuki Yora Nindita Kokichi Arisawa Yoshikuni Kita Megumi Hara Nagato Kuriyama Akie Hirata Haruo Mikami Isao Oze Michiaki Kubo Hideo Tanaka Nobuyuki Hamajima Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men Journal of Epidemiology ALDH2 ADH1B alcohol intake lipid profile |
| title | Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men |
| title_full | Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men |
| title_fullStr | Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men |
| title_full_unstemmed | Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men |
| title_short | Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men |
| title_sort | modification of the associations of alcohol intake with serum low density lipoprotein cholesterol and triglycerides by aldh2 and adh1b polymorphisms in japanese men |
| topic | ALDH2 ADH1B alcohol intake lipid profile |
| url | https://www.jstage.jst.go.jp/article/jea/28/4/28_JE20160189/_pdf |
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